Details for: IL4

Gene ID: 3565

Symbol: IL4

Ensembl ID: ENSG00000113520

Description: interleukin 4

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Interleukin-1 family signaling
    (R-HSA-446652)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-18 signaling
    (R-HSA-9012546)
  • Signaling by interleukins
    (R-HSA-449147)
  • B cell differentiation
    (GO:0030183)
  • Cell surface receptor signaling pathway via jak-stat
    (GO:0007259)
  • Cholesterol metabolic process
    (GO:0008203)
  • Cytokine activity
    (GO:0005125)
  • Dendritic cell differentiation
    (GO:0097028)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Immune response
    (GO:0006955)
  • Interleukin-4 receptor binding
    (GO:0005136)
  • Interleukin-4-mediated signaling pathway
    (GO:0035771)
  • Macrophage activation
    (GO:0042116)
  • Myeloid dendritic cell differentiation
    (GO:0043011)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cellular response to transforming growth factor beta stimulus
    (GO:1903845)
  • Negative regulation of complement-dependent cytotoxicity
    (GO:1903660)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of epithelial cell migration
    (GO:0010633)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of neuroinflammatory response
    (GO:0150079)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Neuroinflammatory response
    (GO:0150076)
  • Positive regulation of amyloid-beta clearance
    (GO:1900223)
  • Positive regulation of atp biosynthetic process
    (GO:2001171)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cellular respiration
    (GO:1901857)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of isotype switching to ige isotypes
    (GO:0048295)
  • Positive regulation of isotype switching to igg isotypes
    (GO:0048304)
  • Positive regulation of macroautophagy
    (GO:0016239)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Positive regulation of t-helper 2 cell cytokine production
    (GO:2000553)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of immune response
    (GO:0050776)
  • Regulation of isotype switching
    (GO:0045191)
  • Regulation of phosphorylation
    (GO:0042325)
  • T cell activation
    (GO:0042110)
  • Type 2 immune response
    (GO:0042092)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.1507
    Cell Significance Index: -1.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1456
    Cell Significance Index: 27.7500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4552
    Cell Significance Index: 4.9000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.4111
    Cell Significance Index: 3.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2227
    Cell Significance Index: 6.5400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2176
    Cell Significance Index: 2.5600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1989
    Cell Significance Index: 2.4600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0436
    Cell Significance Index: 0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0129
    Cell Significance Index: 0.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0099
    Cell Significance Index: 6.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0096
    Cell Significance Index: 1.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0023
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0031
    Cell Significance Index: -0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0038
    Cell Significance Index: -0.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0042
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0070
    Cell Significance Index: -1.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0076
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0090
    Cell Significance Index: -0.9400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0094
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0103
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0107
    Cell Significance Index: -0.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0114
    Cell Significance Index: -1.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0114
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0131
    Cell Significance Index: -1.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0131
    Cell Significance Index: -0.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0154
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0155
    Cell Significance Index: -0.8700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0179
    Cell Significance Index: -0.2000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0183
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0194
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0204
    Cell Significance Index: -1.3700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0206
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0240
    Cell Significance Index: -0.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0242
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0243
    Cell Significance Index: -0.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0249
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0251
    Cell Significance Index: -1.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0255
    Cell Significance Index: -1.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0267
    Cell Significance Index: -1.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0270
    Cell Significance Index: -0.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0275
    Cell Significance Index: -0.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0281
    Cell Significance Index: -0.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0281
    Cell Significance Index: -0.7500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0282
    Cell Significance Index: -0.2200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0304
    Cell Significance Index: -0.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0314
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0337
    Cell Significance Index: -0.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0351
    Cell Significance Index: -0.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0361
    Cell Significance Index: -0.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0365
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0367
    Cell Significance Index: -0.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0368
    Cell Significance Index: -0.9400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0375
    Cell Significance Index: -0.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0386
    Cell Significance Index: -0.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0388
    Cell Significance Index: -1.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0398
    Cell Significance Index: -0.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0419
    Cell Significance Index: -0.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0421
    Cell Significance Index: -1.0100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0434
    Cell Significance Index: -0.5700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0449
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0451
    Cell Significance Index: -0.7300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0454
    Cell Significance Index: -0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0455
    Cell Significance Index: -1.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0458
    Cell Significance Index: -0.9200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0465
    Cell Significance Index: -1.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0470
    Cell Significance Index: -0.9800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0492
    Cell Significance Index: -0.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0492
    Cell Significance Index: -0.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0493
    Cell Significance Index: -0.9700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0494
    Cell Significance Index: -0.5700
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0497
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL-4 is a heterodimeric cytokine composed of two subunits: IL-4α and IL-4β. It is produced by various cell types, including T cells, B cells, and dendritic cells, in response to inflammatory stimuli. IL-4 has a high affinity for the IL-4 receptor, which is composed of two subunits: IL-4Rα and IL-4Rβ. The binding of IL-4 to the IL-4 receptor triggers a signaling cascade that leads to the activation of various transcription factors, including STAT6, which regulates the expression of Th2-related genes. **Pathways and Functions** IL-4 is involved in several signaling pathways, including: 1. **Janus kinase (JAK) activity**: IL-4 activates the JAK/STAT pathway, which leads to the activation of STAT6 and the regulation of Th2-related genes. 2. **Cytokine activity**: IL-4 is a cytokine that regulates the production of other cytokines, including IL-5, IL-6, and IL-10. 3. **Growth factor activity**: IL-4 is a growth factor that regulates the proliferation and differentiation of various cell types, including B cells and dendritic cells. 4. **Immune response**: IL-4 is involved in the regulation of the immune response, including the activation of Th2 cells, B cells, and dendritic cells. 5. **Neuroinflammatory response**: IL-4 has been implicated in the regulation of the neuroinflammatory response, including the activation of microglia and the production of pro-inflammatory cytokines. **Clinical Significance** IL-4 has been implicated in various immune-related disorders, including: 1. **Allergic diseases**: IL-4 is involved in the regulation of allergic responses, including the production of IgE antibodies and the activation of eosinophils. 2. **Asthma**: IL-4 is a key mediator of asthma, a chronic inflammatory disease characterized by airway hyperresponsiveness and inflammation. 3. **Autoimmune conditions**: IL-4 has been implicated in the regulation of autoimmune conditions, including rheumatoid arthritis and lupus. 4. **Cancer**: IL-4 has been implicated in the regulation of cancer progression, including the activation of tumor growth and metastasis. 5. **Neurological disorders**: IL-4 has been implicated in the regulation of neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, IL-4 is a cytokine that plays a crucial role in the regulation of the immune system, particularly in the development and function of Th2 cells, B cells, and dendritic cells. Its dysregulation has been implicated in various immune-related disorders, including allergic diseases, asthma, and autoimmune conditions. Further research is needed to fully understand the mechanisms of IL-4 and its role in human disease.

Genular Protein ID: 3735448967

Symbol: IL4_HUMAN

Name: Interleukin-4

UniProtKB Accession Codes:

P05112 Q14630 Q6NZ77

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3016727

Title: Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

PubMed ID: 3016727

DOI: 10.1073/pnas.83.16.5894

PubMed ID: 2535858

Title: Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

PubMed ID: 2535858

PubMed ID: 7806280

Title: An alternatively spliced interleukin 4 form in lymphoid cells.

PubMed ID: 7806280

DOI: 10.1007/bf00188440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3257560

Title: The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.

PubMed ID: 3257560

DOI: 10.1093/nar/16.2.772

PubMed ID: 1993171

Title: Disulfide assignments in recombinant mouse and human interleukin 4.

PubMed ID: 1993171

DOI: 10.1021/bi00220a011

PubMed ID: 2521231

Title: Influence of recombinant IL-4, IFN-alpha, and IFN-gamma on the production of human IgE-binding factor (soluble CD23).

PubMed ID: 2521231

PubMed ID: 2971718

Title: Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM.

PubMed ID: 2971718

PubMed ID: 7721895

Title: Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.

PubMed ID: 7721895

DOI: 10.1074/jbc.270.16.9630

PubMed ID: 1946344

Title: Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.

PubMed ID: 1946344

DOI: 10.1002/prot.340110204

PubMed ID: 1932028

Title: Secondary structure and topology of human interleukin 4 in solution.

PubMed ID: 1932028

DOI: 10.1021/bi00110a004

PubMed ID: 1400355

Title: Crystal structure of recombinant human interleukin-4.

PubMed ID: 1400355

DOI: 10.2210/pdb2int/pdb

PubMed ID: 1511746

Title: Crystal structure of human recombinant interleukin-4 at 2.25-A resolution.

PubMed ID: 1511746

DOI: 10.1016/0014-5793(92)80739-4

PubMed ID: 1569578

Title: Human interleukin 4. The solution structure of a four-helix bundle protein.

PubMed ID: 1569578

DOI: 10.1016/0022-2836(92)90457-u

PubMed ID: 1567880

Title: 1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy.

PubMed ID: 1567880

DOI: 10.1021/bi00132a026

PubMed ID: 1567881

Title: Determination of the secondary structure and folding topology of human interleukin-4 using three-dimensional heteronuclear magnetic resonance spectroscopy.

PubMed ID: 1567881

DOI: 10.1021/bi00132a027

PubMed ID: 1609277

Title: Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.

PubMed ID: 1609277

DOI: 10.1126/science.256.5064.1673

PubMed ID: 8151703

Title: Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.

PubMed ID: 8151703

DOI: 10.1006/jmbi.1994.1245

PubMed ID: 7664036

Title: Comparison of four independently determined structures of human recombinant interleukin-4.

PubMed ID: 7664036

DOI: 10.1038/nsb0594-301

PubMed ID: 10219247

Title: Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.

PubMed ID: 10219247

DOI: 10.1016/s0092-8674(00)80736-9

PubMed ID: 11526337

Title: Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.

PubMed ID: 11526337

DOI: 10.1107/s0907444901009799

PubMed ID: 18243101

Title: Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

PubMed ID: 18243101

DOI: 10.1016/j.cell.2007.12.030

PubMed ID: 14681304

Title: Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

PubMed ID: 14681304

DOI: 10.1093/hmg/ddh039

Sequence Information:

  • Length: 153
  • Mass: 17492
  • Checksum: 8725BF64B34D45F7
  • Sequence:
    • MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS 
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL 
NSCPVKEANQ STLENFLERL KTIMREKYSK CSS

Genular Protein ID: 4236654227

Symbol: Q5FC01_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5FC01

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 36 Gene3D 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 137
  • Mass: 15797
  • Checksum: 3B621F60D0F0D261
  • Sequence:
    • MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKNTTEK ETFCRAATVL 
RQFYSHHEKD TRCLGATAQQ FHRHKQLIRF LKRLDRNLWG LAGLNSCPVK EANQSTLENF 
LERLKTIMRE KYSKCSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.