Details for: IL9

Gene ID: 3578

Symbol: IL9

Ensembl ID: ENSG00000145839

Description: interleukin 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.6247
    Cell Significance Index: 11.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.8540
    Cell Significance Index: 10.7900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.8041
    Cell Significance Index: 6.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5110
    Cell Significance Index: 5.2900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.3998
    Cell Significance Index: 4.2200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.1488
    Cell Significance Index: 1.4500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.1325
    Cell Significance Index: 1.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0531
    Cell Significance Index: 0.7600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0506
    Cell Significance Index: 0.5700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0089
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0018
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0009
    Cell Significance Index: -0.0500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0030
    Cell Significance Index: -1.0900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0153
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0169
    Cell Significance Index: -0.4300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0202
    Cell Significance Index: -0.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0254
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0290
    Cell Significance Index: -0.4400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0320
    Cell Significance Index: -0.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0338
    Cell Significance Index: -1.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0370
    Cell Significance Index: -1.2100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0372
    Cell Significance Index: -0.4400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0388
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0405
    Cell Significance Index: -1.1900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0410
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0415
    Cell Significance Index: -0.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0426
    Cell Significance Index: -0.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0431
    Cell Significance Index: -0.8600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0437
    Cell Significance Index: -0.5900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0456
    Cell Significance Index: -0.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0457
    Cell Significance Index: -0.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0464
    Cell Significance Index: -0.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0507
    Cell Significance Index: -0.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0508
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0512
    Cell Significance Index: -0.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0521
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0527
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0532
    Cell Significance Index: -1.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0539
    Cell Significance Index: -1.0600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0544
    Cell Significance Index: -0.6400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0545
    Cell Significance Index: -0.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0545
    Cell Significance Index: -1.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0550
    Cell Significance Index: -1.1100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0556
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0559
    Cell Significance Index: -0.6800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0561
    Cell Significance Index: -0.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0565
    Cell Significance Index: -1.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0574
    Cell Significance Index: -0.6200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0575
    Cell Significance Index: -0.7000
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0585
    Cell Significance Index: -0.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0589
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0594
    Cell Significance Index: -0.5900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0605
    Cell Significance Index: -0.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0607
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0610
    Cell Significance Index: -0.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0619
    Cell Significance Index: -0.7400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0642
    Cell Significance Index: -0.8100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0652
    Cell Significance Index: -0.7700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0656
    Cell Significance Index: -0.8800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0667
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0670
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0680
    Cell Significance Index: -0.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0683
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0692
    Cell Significance Index: -0.7300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0697
    Cell Significance Index: -0.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0700
    Cell Significance Index: -1.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0710
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0714
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0720
    Cell Significance Index: -0.6900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0720
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0735
    Cell Significance Index: -0.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0737
    Cell Significance Index: -0.9800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0751
    Cell Significance Index: -0.9800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0754
    Cell Significance Index: -1.0100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0798
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0830
    Cell Significance Index: -0.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0868
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0871
    Cell Significance Index: -0.8900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0872
    Cell Significance Index: -1.2200
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0881
    Cell Significance Index: -0.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0883
    Cell Significance Index: -0.7200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0901
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0931
    Cell Significance Index: -0.9500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0941
    Cell Significance Index: -1.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.0951
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL-9 is a secreted glycoprotein that belongs to the interleukin-2 family, which also includes IL-2, IL-4, IL-5, IL-6, IL-10, IL-11, IL-15, and IL-21. IL-9 is primarily produced by T cells, particularly type I NK T cells, and is also expressed by other cell types such as microglial cells, endothelial cells, and goblet cells. The protein is characterized by its ability to bind to the IL-9 receptor, which is composed of two subunits, α and β, both of which are expressed on the surface of target cells. **Pathways and Functions:** IL-9 exerts its effects through binding to its receptor, triggering a signaling cascade that involves the activation of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways. This cascade leads to the activation of various transcription factors, including STAT1, STAT3, and NF-κB, which in turn regulate the expression of genes involved in B cell differentiation, proliferation, and survival. IL-9 also promotes the production of other cytokines, such as IL-5, and regulates the activity of immune cells, including natural killer T cells and macrophages. IL-9's functions can be broadly categorized into three main areas: 1. **B cell differentiation and proliferation:** IL-9 promotes the differentiation of B cells into plasma cells and enhances their proliferation, leading to the production of antibodies. 2. **Cytokine production:** IL-9 regulates the production of other cytokines, including IL-5, which is involved in the differentiation of eosinophils. 3. **Immune cell regulation:** IL-9 modulates the activity of immune cells, including natural killer T cells and macrophages, which are involved in the clearance of pathogens and the regulation of inflammation. **Clinical Significance:** IL-9 has been implicated in various disease states, including: 1. **Allergic diseases:** IL-9 has been shown to play a critical role in the development of allergic diseases, such as asthma and atopic dermatitis, by promoting the production of eosinophils and the activation of immune cells. 2. **Cancer:** IL-9 has been implicated in the progression of certain types of cancer, including leukemia and lymphoma, by promoting the proliferation and survival of cancer cells. 3. **Inflammatory diseases:** IL-9 has been shown to contribute to the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis, by promoting the activation of immune cells and the production of pro-inflammatory cytokines. 4. **Autoimmune diseases:** IL-9 has been implicated in the development of autoimmune diseases, such as lupus and rheumatoid arthritis, by promoting the activation of immune cells and the production of autoantibodies. In conclusion, IL-9 is a multifunctional cytokine that plays a critical role in the regulation of immune responses, particularly in the context of B cell differentiation, proliferation, and survival. Its dysregulation has been implicated in various disease states, highlighting the importance of IL-9 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 3940644496

Symbol: IL9_HUMAN

Name: Interleukin-9

UniProtKB Accession Codes:

P15248

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2508790

Title: Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40.

PubMed ID: 2508790

PubMed ID: 2129501

Title: Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40.

PubMed ID: 2129501

DOI: 10.1016/1043-4666(90)90037-t

PubMed ID: 1971295

Title: Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.

PubMed ID: 1971295

PubMed ID: 1901233

Title: Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells.

PubMed ID: 1901233

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29742432

Title: IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut.

PubMed ID: 29742432

DOI: 10.1016/j.celrep.2018.04.034

Sequence Information:

  • Length: 144
  • Mass: 15909
  • Checksum: 2EAA08690558ECAB
  • Sequence:
    • MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP 
SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN 
ALTFLKSLLE IFQKEKMRGM RGKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.