Details for: MC3R

Gene ID: 4159

Symbol: MC3R

Ensembl ID: ENSG00000124089

Description: melanocortin 3 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.54
    Marker Score: 103668
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.98
    Marker Score: 161991
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.66
    Marker Score: 8239
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32715
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6805
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3166
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.71
    Marker Score: 997
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10770
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.23
    Marker Score: 7483
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3631.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.18
    Marker Score: 656
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.12
    Marker Score: 2116
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32672
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5319
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1699
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10211
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 323
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2907
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 185
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 105.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 360
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 107.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 156
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.27
    Marker Score: 368
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 509
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.17
    Marker Score: 107
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 119.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.12
    Marker Score: 95
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 128
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 90
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 82
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 106
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.07
    Marker Score: 106
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 192
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 108
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 105
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.04
    Marker Score: 120
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 78
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.03
    Marker Score: 461
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 116
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.03
    Marker Score: 108
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.02
    Marker Score: 106
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 111
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 73
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 111
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 101
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 111

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Other Information

**Key characteristics:** * MC3R is a single-pass membrane protein with a molecular weight of approximately 130 kDa. * It is expressed in high levels in the central nervous system, particularly in the hypothalamus and pituitary gland. * MC3R is also expressed in peripheral tissues, including blood vessels, skin, and adipose tissue. * It is a ligand for the melanocortin hormone, which is a peptide hormone that is involved in regulating blood pressure and heart rate. **Pathways and functions:** * MC3R is a key regulator of the G alpha (s) signaling pathway, which is involved in a variety of cellular processes, including blood pressure regulation, heart rate regulation, and metabolism. * It is also involved in the regulation of the peptide hormone-mediated signaling pathway, which is involved in growth and differentiation, and the regulation of inflammation. * MC3R is a potential therapeutic target for a variety of diseases, including hypertension, heart failure, and obesity. **Clinical significance:** * Mutations in MC3R have been linked to a number of human diseases, including hypertension, heart failure, and obesity. * In hypertension, mutations in MC3R are associated with an increased risk of developing high blood pressure. * In heart failure, mutations in MC3R are associated with an increased risk of heart failure. * In obesity, mutations in MC3R are associated with an increased risk of obesity-related diseases, such as type 2 diabetes and non-alcoholic fatty liver disease.

Genular Protein ID: 3058062460

Symbol: MC3R_HUMAN

Name: Melanocortin receptor 3

UniProtKB Accession Codes:

P41968 Q4KN27 Q9H517

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 4 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8463333

Title: Molecular cloning of a novel melanocortin receptor.

PubMed ID: 8463333

DOI: 10.1016/s0021-9258(18)53088-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22433616

Title: Identification of the translation start site of the human melanocortin 3 receptor.

PubMed ID: 22433616

DOI: 10.1159/000336070

PubMed ID: 11889220

Title: A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.

PubMed ID: 11889220

DOI: 10.1210/jcem.87.3.8461

PubMed ID: 15292330

Title: Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

PubMed ID: 15292330

DOI: 10.1210/jc.2004-0367

PubMed ID: 18231126

Title: Sporadic mutations in melanocortin receptor 3 in morbid obese individuals.

PubMed ID: 18231126

DOI: 10.1038/sj.ejhg.5202005

Sequence Information:

  • Length: 323
  • Mass: 36043
  • Checksum: 98B016FC80802A97
  • Sequence:
    • MNASCCLPSV QPTLPNGSEH LQAPFFSNQS SSAFCEQVFI KPEVFLSLGI VSLLENILVI 
LAVVRNGNLH SPMYFFLCSL AVADMLVSVS NALETIMIAI VHSDYLTFED QFIQHMDNIF 
DSMICISLVA SICNLLAIAV DRYVTIFYAL RYHSIMTVRK ALTLIVAIWV CCGVCGVVFI 
VYSESKMVIV CLITMFFAMM LLMGTLYVHM FLFARLHVKR IAALPPADGV APQQHSCMKG 
AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA 
FRSLELRNTF REILCGCNGM NLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.