Details for: MC3R

Gene ID: 4159

Symbol: MC3R

Ensembl ID: ENSG00000124089

Description: melanocortin 3 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.9705
    Cell Significance Index: 18.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4971
    Cell Significance Index: 36.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.0486
    Cell Significance Index: 26.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.6680
    Cell Significance Index: 7.4000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2427
    Cell Significance Index: 3.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1773
    Cell Significance Index: 3.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0890
    Cell Significance Index: 1.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0388
    Cell Significance Index: 0.5300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0186
    Cell Significance Index: 0.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0117
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0077
    Cell Significance Index: -2.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0108
    Cell Significance Index: -0.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0110
    Cell Significance Index: -2.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0132
    Cell Significance Index: -1.8100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0193
    Cell Significance Index: -0.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0215
    Cell Significance Index: -0.2100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0261
    Cell Significance Index: -0.2500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0270
    Cell Significance Index: -0.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0290
    Cell Significance Index: -0.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0316
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0318
    Cell Significance Index: -2.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0350
    Cell Significance Index: -2.1500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0497
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0509
    Cell Significance Index: -5.8300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0520
    Cell Significance Index: -0.6100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0521
    Cell Significance Index: -0.5600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0612
    Cell Significance Index: -0.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0622
    Cell Significance Index: -2.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0628
    Cell Significance Index: -0.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0649
    Cell Significance Index: -1.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0699
    Cell Significance Index: -0.6100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0726
    Cell Significance Index: -0.6800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0752
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0771
    Cell Significance Index: -2.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0805
    Cell Significance Index: -0.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0866
    Cell Significance Index: -1.8700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0897
    Cell Significance Index: -0.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0958
    Cell Significance Index: -1.1700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0964
    Cell Significance Index: -0.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0984
    Cell Significance Index: -1.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1001
    Cell Significance Index: -2.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1029
    Cell Significance Index: -1.3500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1044
    Cell Significance Index: -1.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1045
    Cell Significance Index: -2.1800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1067
    Cell Significance Index: -1.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1103
    Cell Significance Index: -2.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1111
    Cell Significance Index: -2.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1123
    Cell Significance Index: -2.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1123
    Cell Significance Index: -1.6300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1214
    Cell Significance Index: -1.5900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1223
    Cell Significance Index: -1.6500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1276
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1304
    Cell Significance Index: -1.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1383
    Cell Significance Index: -0.7400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1548
    Cell Significance Index: -1.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1630
    Cell Significance Index: -1.5300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1673
    Cell Significance Index: -2.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1680
    Cell Significance Index: -2.2400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1689
    Cell Significance Index: -2.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1730
    Cell Significance Index: -1.6400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1739
    Cell Significance Index: -1.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1749
    Cell Significance Index: -2.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1759
    Cell Significance Index: -2.2200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1765
    Cell Significance Index: -2.0200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1769
    Cell Significance Index: -2.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1807
    Cell Significance Index: -2.1400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1815
    Cell Significance Index: -2.1600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1820
    Cell Significance Index: -1.9200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1831
    Cell Significance Index: -2.1900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1852
    Cell Significance Index: -1.9100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1927
    Cell Significance Index: -2.4100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1935
    Cell Significance Index: -2.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2005
    Cell Significance Index: -2.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2019
    Cell Significance Index: -2.2000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2032
    Cell Significance Index: -2.4700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2070
    Cell Significance Index: -2.1700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2124
    Cell Significance Index: -2.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2268
    Cell Significance Index: -2.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2271
    Cell Significance Index: -2.6500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2271
    Cell Significance Index: -2.1800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2344
    Cell Significance Index: -2.2300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2365
    Cell Significance Index: -2.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2382
    Cell Significance Index: -1.5500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2439
    Cell Significance Index: -2.5900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2545
    Cell Significance Index: -1.5100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.2649
    Cell Significance Index: -2.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2654
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.2881
    Cell Significance Index: -2.7100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2930
    Cell Significance Index: -2.9500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3099
    Cell Significance Index: -2.1500
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.3215
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3306
    Cell Significance Index: -2.6100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3482
    Cell Significance Index: -2.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3718
    Cell Significance Index: -6.1300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.4644
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MC3R is a member of the melanocortin receptor family, which is induced by the melanocortin peptide family, including alpha-melanocyte-stimulating hormone (α-MSH) and beta-MSH. It is characterized by its high degree of specificity for α-MSH, which binds to the receptor via a high-affinity interaction. MC3R is primarily expressed in the cytoplasm and plasma membrane of various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells. **Pathways and Functions:** MC3R signaling is initiated by the binding of α-MSH to the receptor, which triggers the activation of Gαs proteins, leading to the stimulation of adenylate cyclase and the production of cyclic AMP (cAMP). This signaling cascade has far-reaching consequences, influencing various physiological processes, including: 1. **Immune regulation:** MC3R has been implicated in the regulation of immune responses, including the modulation of T-cell activation, cytokine production, and the suppression of inflammatory responses. 2. **Circadian rhythm:** MC3R is involved in the regulation of circadian gene expression, influencing the expression of genes involved in the maintenance of the circadian clock. 3. **Cardiovascular function:** MC3R signaling has been shown to regulate blood pressure, heart rate, and cardiac function, highlighting its importance in cardiovascular health. 4. **Metabolic regulation:** MC3R has been linked to the regulation of metabolic processes, including glucose metabolism and lipid metabolism. **Clinical Significance:** MC3R has significant implications for various clinical conditions, including: 1. **Immune-mediated disorders:** MC3R has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Circadian rhythm disorders:** MC3R dysfunction has been linked to circadian rhythm disorders, such as delayed sleep phase syndrome (DSPS) and non-24-hour sleep-wake disorder (N24HS). 3. **Cardiovascular disease:** MC3R signaling has been shown to regulate blood pressure and cardiac function, highlighting its importance in cardiovascular health. 4. **Metabolic disorders:** MC3R has been implicated in the regulation of metabolic processes, including glucose metabolism and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, MC3R is a multifunctional receptor that plays a crucial role in immune regulation, circadian rhythm, and cardiovascular function. Its dysregulation has been implicated in various clinical conditions, highlighting the need for further research into the mechanisms underlying MC3R signaling and its potential therapeutic applications.

Genular Protein ID: 3058062460

Symbol: MC3R_HUMAN

Name: Melanocortin receptor 3

UniProtKB Accession Codes:

P41968 Q4KN27 Q9H517

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8463333

Title: Molecular cloning of a novel melanocortin receptor.

PubMed ID: 8463333

DOI: 10.1016/s0021-9258(18)53088-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22433616

Title: Identification of the translation start site of the human melanocortin 3 receptor.

PubMed ID: 22433616

DOI: 10.1159/000336070

PubMed ID: 11889220

Title: A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.

PubMed ID: 11889220

DOI: 10.1210/jcem.87.3.8461

PubMed ID: 15292330

Title: Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

PubMed ID: 15292330

DOI: 10.1210/jc.2004-0367

PubMed ID: 18231126

Title: Sporadic mutations in melanocortin receptor 3 in morbid obese individuals.

PubMed ID: 18231126

DOI: 10.1038/sj.ejhg.5202005

Sequence Information:

  • Length: 323
  • Mass: 36043
  • Checksum: 98B016FC80802A97
  • Sequence:
    • MNASCCLPSV QPTLPNGSEH LQAPFFSNQS SSAFCEQVFI KPEVFLSLGI VSLLENILVI 
LAVVRNGNLH SPMYFFLCSL AVADMLVSVS NALETIMIAI VHSDYLTFED QFIQHMDNIF 
DSMICISLVA SICNLLAIAV DRYVTIFYAL RYHSIMTVRK ALTLIVAIWV CCGVCGVVFI 
VYSESKMVIV CLITMFFAMM LLMGTLYVHM FLFARLHVKR IAALPPADGV APQQHSCMKG 
AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA 
FRSLELRNTF REILCGCNGM NLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.