Details for: MT1B

Gene ID: 4490

Symbol: MT1B

Ensembl ID: ENSG00000169688

Description: metallothionein 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.1392
    Cell Significance Index: 52.8000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.8284
    Cell Significance Index: 3.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2863
    Cell Significance Index: 4.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2366
    Cell Significance Index: 5.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1738
    Cell Significance Index: 2.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1387
    Cell Significance Index: 2.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0192
    Cell Significance Index: 1.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0159
    Cell Significance Index: 2.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0142
    Cell Significance Index: -0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0144
    Cell Significance Index: -2.8500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0186
    Cell Significance Index: -0.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0187
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0211
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0239
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0250
    Cell Significance Index: -2.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0283
    Cell Significance Index: -5.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0305
    Cell Significance Index: -2.1100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0356
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0492
    Cell Significance Index: -0.8200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0628
    Cell Significance Index: -0.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0671
    Cell Significance Index: -2.1500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0679
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0700
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0703
    Cell Significance Index: -0.7800
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0766
    Cell Significance Index: -0.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0779
    Cell Significance Index: -1.6200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0835
    Cell Significance Index: -0.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0838
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0975
    Cell Significance Index: -0.6000
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.1055
    Cell Significance Index: -0.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1071
    Cell Significance Index: -2.8700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1089
    Cell Significance Index: -0.8600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1146
    Cell Significance Index: -1.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1193
    Cell Significance Index: -2.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1243
    Cell Significance Index: -3.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1285
    Cell Significance Index: -3.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1309
    Cell Significance Index: -0.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1349
    Cell Significance Index: -6.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1368
    Cell Significance Index: -3.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1384
    Cell Significance Index: -3.0300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1425
    Cell Significance Index: -1.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1448
    Cell Significance Index: -2.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1529
    Cell Significance Index: -2.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1586
    Cell Significance Index: -2.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1659
    Cell Significance Index: -4.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1683
    Cell Significance Index: -3.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1692
    Cell Significance Index: -6.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1694
    Cell Significance Index: -1.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1717
    Cell Significance Index: -2.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1726
    Cell Significance Index: -4.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1772
    Cell Significance Index: -4.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1773
    Cell Significance Index: -3.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1841
    Cell Significance Index: -4.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1862
    Cell Significance Index: -2.7900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1880
    Cell Significance Index: -2.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1922
    Cell Significance Index: -1.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2059
    Cell Significance Index: -3.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2073
    Cell Significance Index: -2.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2115
    Cell Significance Index: -3.4300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2126
    Cell Significance Index: -2.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2179
    Cell Significance Index: -6.2500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2204
    Cell Significance Index: -2.6600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.2333
    Cell Significance Index: -2.2000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2424
    Cell Significance Index: -3.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2492
    Cell Significance Index: -6.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2559
    Cell Significance Index: -1.5900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2568
    Cell Significance Index: -2.7800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2604
    Cell Significance Index: -3.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2634
    Cell Significance Index: -3.2900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2676
    Cell Significance Index: -2.7600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2711
    Cell Significance Index: -2.8800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2756
    Cell Significance Index: -3.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2767
    Cell Significance Index: -3.2700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2778
    Cell Significance Index: -3.1300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2779
    Cell Significance Index: -3.0500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2821
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2910
    Cell Significance Index: -3.0700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2945
    Cell Significance Index: -3.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2965
    Cell Significance Index: -3.2300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2993
    Cell Significance Index: -3.1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3024
    Cell Significance Index: -3.0900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3034
    Cell Significance Index: -3.3300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3043
    Cell Significance Index: -3.4000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3055
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3089
    Cell Significance Index: -2.9000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3089
    Cell Significance Index: -3.3000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3139
    Cell Significance Index: -3.2900
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3141
    Cell Significance Index: -3.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3168
    Cell Significance Index: -4.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3172
    Cell Significance Index: -6.1900
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.3187
    Cell Significance Index: -2.5800
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.3193
    Cell Significance Index: -2.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MT1B shares structural and functional similarities with other metallothioneins, including the ability to bind metals such as zinc, copper, and cadmium. The protein has a high affinity for zinc ions, which is essential for its biological function. MT1B is also involved in negative regulation of growth, suggesting its role in modulating cellular proliferation and differentiation. **Pathways and Functions:** MT1B is involved in several cellular pathways, including: 1. **Intracellular zinc ion homeostasis**: MT1B plays a crucial role in maintaining zinc homeostasis within cells by binding and sequestering excess zinc ions, thereby preventing oxidative stress and cellular damage. 2. **Detoxification of copper ion**: MT1B has been shown to bind and sequester copper ions, which can be toxic in high concentrations. This function helps protect cells from copper-induced oxidative stress. 3. **Response to metal ions**: MT1B is activated in response to metal ions, such as cadmium and copper, and regulates their intracellular levels. 4. **Regulation of growth**: MT1B has been implicated in negative regulation of growth, suggesting its role in modulating cellular proliferation and differentiation. **Clinical Significance:** MT1B has been implicated in various diseases, including: 1. **Alzheimer's disease**: MT1B has been shown to be overexpressed in the brains of Alzheimer's patients, suggesting its potential role in disease pathogenesis. 2. **Cancer**: MT1B has been found to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumor progression and metastasis. 3. **Neurodegenerative diseases**: MT1B has been implicated in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease, suggesting its potential role in disease pathogenesis. In conclusion, MT1B plays a crucial role in maintaining metal ion homeostasis and responding to cellular stress. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications. **References:** * [Insert relevant references to support the discussion] Note: This article is a summary of the gene MT1B and its functions, and is not meant to be a comprehensive review of the literature. Further research is necessary to fully understand the mechanisms of action and clinical significance of MT1B.

Genular Protein ID: 3901952382

Symbol: MT1B_HUMAN

Name: Metallothionein-1B

UniProtKB Accession Codes:

P07438 Q86YX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 28 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3785191

Title: Structure and tissue-specific expression of the human metallothionein IB gene.

PubMed ID: 3785191

DOI: 10.1128/mcb.6.6.2149-2157.1986

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 61
  • Mass: 6115
  • Checksum: 8DC566E5462810D3
  • Sequence:
    • MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC KGSSEKCRCC 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.