Details for: OCM2

Gene ID: 4951

Symbol: OCM2

Ensembl ID: ENSG00000135175

Description: oncomodulin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.3926
    Cell Significance Index: 18.0200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.2237
    Cell Significance Index: 24.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.0910
    Cell Significance Index: 18.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8007
    Cell Significance Index: 19.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.7850
    Cell Significance Index: 10.7700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.7784
    Cell Significance Index: 7.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4988
    Cell Significance Index: 7.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3574
    Cell Significance Index: 3.7000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2803
    Cell Significance Index: 2.5700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.2645
    Cell Significance Index: 2.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0797
    Cell Significance Index: 0.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0675
    Cell Significance Index: 0.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0593
    Cell Significance Index: 0.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0510
    Cell Significance Index: 0.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0402
    Cell Significance Index: 0.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0388
    Cell Significance Index: 1.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0251
    Cell Significance Index: 0.6300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0241
    Cell Significance Index: 0.2800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0213
    Cell Significance Index: 0.2800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0193
    Cell Significance Index: 0.1700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0121
    Cell Significance Index: 0.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0117
    Cell Significance Index: 0.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0083
    Cell Significance Index: 0.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0075
    Cell Significance Index: 0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0065
    Cell Significance Index: 1.8700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0063
    Cell Significance Index: 0.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0032
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0030
    Cell Significance Index: 0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0022
    Cell Significance Index: 0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0016
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0007
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0018
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0019
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0022
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0025
    Cell Significance Index: -0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0028
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0029
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0040
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0045
    Cell Significance Index: -0.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0045
    Cell Significance Index: -0.1700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0047
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0052
    Cell Significance Index: -0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0052
    Cell Significance Index: -0.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0057
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0060
    Cell Significance Index: -0.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0077
    Cell Significance Index: -0.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0081
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0085
    Cell Significance Index: -0.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0087
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0090
    Cell Significance Index: -0.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0092
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0093
    Cell Significance Index: -0.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0095
    Cell Significance Index: -0.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0098
    Cell Significance Index: -0.1000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0108
    Cell Significance Index: -0.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0114
    Cell Significance Index: -0.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0119
    Cell Significance Index: -0.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0120
    Cell Significance Index: -0.1400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0123
    Cell Significance Index: -0.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0129
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0133
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0135
    Cell Significance Index: -0.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0138
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0140
    Cell Significance Index: -0.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0142
    Cell Significance Index: -0.2800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0148
    Cell Significance Index: -0.2000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0154
    Cell Significance Index: -0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0161
    Cell Significance Index: -0.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression:** OCM2 is significantly expressed in progenitor cells, blood vessel endothelial cells, erythrocytes, plasma cells, megakaryocytes, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal crypt stem cells of the colon. 2. **Calcium ion binding:** OCM2 contains a calcium-binding domain, which suggests its potential involvement in calcium homeostasis and signaling pathways. 3. **Evolutionary conservation:** The OCM2 gene is conserved across species, indicating its evolutionary significance and potential importance in human health. **Pathways and Functions:** 1. **Calcium signaling:** OCM2's calcium-binding domain may participate in calcium-dependent signaling pathways, influencing cell proliferation, differentiation, and survival. 2. **Cell adhesion and migration:** OCM2 may play a role in cell adhesion and migration, particularly in the context of tissue development and repair. 3. **Stem cell maintenance:** OCM2's expression in stem cells, including intestinal crypt stem cells, suggests its involvement in maintaining stem cell populations and tissue homeostasis. 4. **Neurological functions:** OCM2's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells implies its potential role in neuronal development, function, and maintenance. **Clinical Significance:** 1. **Cancer research:** Despite its name, OCM2 does not appear to be a direct oncogene. However, its expression in various cancers, such as colorectal cancer, may indicate its potential as a biomarker or therapeutic target. 2. **Neurological disorders:** OCM2's expression in neurological tissues suggests its potential involvement in neurodevelopmental and neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, or schizophrenia. 3. **Cardiovascular diseases:** OCM2's expression in blood vessel endothelial cells may indicate its role in cardiovascular health, particularly in the context of cardiovascular disease or atherosclerosis. 4. **Regenerative medicine:** OCM2's expression in stem cells and progenitor cells suggests its potential as a therapeutic target for regenerative medicine applications, such as tissue repair and replacement. In conclusion, the OCM2 gene product exhibits a wide range of tissue-specific expressions, suggesting its involvement in various physiological processes. Further research is needed to fully elucidate the functions and clinical significance of OCM2, but its potential as a biomarker, therapeutic target, or therapeutic agent in regenerative medicine offers promising avenues for investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.