Details for: OMP

Gene ID: 4975

Symbol: OMP

Ensembl ID: ENSG00000254550

Description: olfactory marker protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0894
    Cell Significance Index: 1.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0538
    Cell Significance Index: 0.7700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0532
    Cell Significance Index: 0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0252
    Cell Significance Index: 0.6400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0192
    Cell Significance Index: 0.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0184
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0124
    Cell Significance Index: 0.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0094
    Cell Significance Index: 0.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0093
    Cell Significance Index: 0.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0059
    Cell Significance Index: 0.0600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0059
    Cell Significance Index: 0.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0018
    Cell Significance Index: 0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0050
    Cell Significance Index: -0.6800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0092
    Cell Significance Index: -0.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0104
    Cell Significance Index: -0.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0111
    Cell Significance Index: -0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0179
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0179
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0181
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0184
    Cell Significance Index: -0.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0187
    Cell Significance Index: -1.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0214
    Cell Significance Index: -0.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0214
    Cell Significance Index: -0.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0216
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0228
    Cell Significance Index: -0.2800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0242
    Cell Significance Index: -0.2900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0252
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0270
    Cell Significance Index: -0.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0280
    Cell Significance Index: -0.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0297
    Cell Significance Index: -0.3500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0306
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0323
    Cell Significance Index: -0.3300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0333
    Cell Significance Index: -0.3800
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0349
    Cell Significance Index: -0.3200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0351
    Cell Significance Index: -0.3700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0377
    Cell Significance Index: -0.4100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0387
    Cell Significance Index: -0.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0394
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0396
    Cell Significance Index: -0.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0398
    Cell Significance Index: -0.8300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0400
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0416
    Cell Significance Index: -0.7200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0418
    Cell Significance Index: -0.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0476
    Cell Significance Index: -0.3700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0483
    Cell Significance Index: -0.6400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0489
    Cell Significance Index: -0.2900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0546
    Cell Significance Index: -0.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0565
    Cell Significance Index: -0.8200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0574
    Cell Significance Index: -0.7300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0575
    Cell Significance Index: -0.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0600
    Cell Significance Index: -0.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0611
    Cell Significance Index: -0.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0613
    Cell Significance Index: -0.8400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0613
    Cell Significance Index: -0.6500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0631
    Cell Significance Index: -0.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0686
    Cell Significance Index: -0.6500
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0705
    Cell Significance Index: -0.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0726
    Cell Significance Index: -0.9400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0735
    Cell Significance Index: -0.7500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0749
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0752
    Cell Significance Index: -0.6200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0764
    Cell Significance Index: -0.9000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0797
    Cell Significance Index: -0.6300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0810
    Cell Significance Index: -0.5300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0823
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0830
    Cell Significance Index: -0.8400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0834
    Cell Significance Index: -0.7600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0837
    Cell Significance Index: -1.0500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0838
    Cell Significance Index: -1.0500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0840
    Cell Significance Index: -0.9100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0856
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0878
    Cell Significance Index: -0.5500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0880
    Cell Significance Index: -0.8400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0909
    Cell Significance Index: -0.9900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0936
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0950
    Cell Significance Index: -0.7300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0961
    Cell Significance Index: -0.8700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0997
    Cell Significance Index: -0.8900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1038
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1108
    Cell Significance Index: -1.0400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1143
    Cell Significance Index: -1.0500
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.1212
    Cell Significance Index: -1.0500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1285
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1385
    Cell Significance Index: -0.9200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1398
    Cell Significance Index: -0.6500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1589
    Cell Significance Index: -1.3400
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1631
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OMP is a 17-kDa protein that belongs to the S100 protein family. It is secreted by the olfactory epithelial cells and has been shown to interact with various receptors and molecules, including olfactory receptors, chemokines, and cytokines. OMP is highly expressed in the olfactory epithelium, but its expression is also observed in other tissues, including the gut, where it is associated with goblet cells and intestinal epithelial cells. **Pathways and Functions:** OMP's primary function is to regulate the sensory perception of odorant molecules in the olfactory system. It achieves this by binding to specific receptors, which triggers a signaling cascade that ultimately leads to the activation of olfactory neurons. Beyond its role in sensory perception, OMP has been shown to modulate immune responses, particularly in the context of the gut-associated lymphoid tissue (GALT). OMP has been shown to interact with various immune cells, including T cells, B cells, and dendritic cells, influencing their activation, proliferation, and cytokine production. In the gut, OMP is expressed by goblet cells and intestinal epithelial cells, where it plays a role in maintaining the integrity of the epithelial barrier and regulating the immune response to luminal antigens. Additionally, OMP has been implicated in the regulation of neurogenesis and neuronal cell growth, suggesting a potential role in the development and maintenance of the olfactory system. **Clinical Significance:** OMP's role in the olfactory system has significant implications for individuals with olfactory dysfunction or disorders, such as anosmia or hyposmia. Research has shown that OMP expression is reduced in patients with these conditions, suggesting a potential therapeutic target for the treatment of olfactory disorders. Furthermore, OMP's immunomodulatory properties have been explored in the context of inflammatory bowel disease (IBD) and cancer. Studies have shown that OMP can modulate the immune response in IBD, reducing inflammation and promoting tissue repair. Additionally, OMP has been shown to inhibit the growth of cancer cells, suggesting a potential role in cancer prevention and treatment. In conclusion, the Olfactory Marker Protein (OMP) is a multifunctional protein with significant implications for our understanding of immune regulation, sensory perception, and disease. Further research is needed to fully elucidate the mechanisms underlying OMP's functions and to explore its potential therapeutic applications.

Genular Protein ID: 780229995

Symbol: OMP_HUMAN

Name: Olfactory marker protein

UniProtKB Accession Codes:

P47874 Q562G2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8034318

Title: Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization.

PubMed ID: 8034318

DOI: 10.1006/geno.1994.1200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 163
  • Mass: 18937
  • Checksum: EECD8AD16E7A328E
  • Sequence:
    • MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ 
QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA 
DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.