Details for: PGK2

Gene ID: 5232

Symbol: PGK2

Ensembl ID: ENSG00000170950

Description: phosphoglycerate kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.55
    Marker Score: 103692
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.98
    Marker Score: 162006
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53013
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.68
    Marker Score: 8263
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3185
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10794
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.33
    Marker Score: 2413
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7559
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32686
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 284
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.62
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 918
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 731
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 203
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 96
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 107.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.24
    Marker Score: 95
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1240
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3168
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 90
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 93
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 187
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.08
    Marker Score: 141.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 96
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 78.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 191
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 94
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 183.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 96
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 83
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 94
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 96
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 59
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 88
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 93

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Other Information

**Key characteristics:** * PGK2 is a serine/threonine kinase that is highly expressed in various tissues, including the brain, liver, kidney, and skeletal muscle. * It is a key enzyme in the citric acid cycle of the mitochondria, where it catalyzes the transfer of a phosphate group from phosphoglycerate to ADP, resulting in the production of ATP. * PGK2 is also involved in the regulation of cell signaling pathways, including the activation of protein kinases and the regulation of cell proliferation, differentiation, and apoptosis. **Pathways and functions:** * PGK2 is involved in multiple cellular pathways, including: * Adp binding: It is a key enzyme in the regulation of energy metabolism, and its activity is increased in conditions of energy deprivation. * Atp binding: PGK2 is also involved in the regulation of calcium signaling and muscle contraction. * Canonical glycolysis: It is involved in the regulation of glucose metabolism and the production of ATP. * Cytosol: PGK2 is present in the cytosol of cells and is involved in various cellular processes, including protein synthesis, DNA repair, and cell signaling. * Flagellated sperm motility: PGK2 is expressed in high levels in the flagella of spermatozoa, where it is involved in the regulation of sperm motility. * Gluconeogenesis: PGK2 is involved in the regulation of gluconeogenesis, the process by which the body converts non-carbohydrate sources into glucose. * Glucose metabolism: PGK2 is involved in the regulation of glucose metabolism, including the production of glucose-6-phosphate from glucose. * Glycolysis: PGK2 is involved in the regulation of glycolysis, the process by which glucose is broken down into pyruvate. * Metabolism: PGK2 is involved in various cellular processes, including protein synthesis, cell cycle regulation, and apoptosis. * Nucleus: PGK2 is involved in the regulation of gene expression and cell cycle regulation. * Phosphoglycerate kinase activity: PGK2 is a key enzyme in the regulation of phosphoglycerate kinase activity, which is essential for the maintenance of cellular energy levels. * Phosphorylation: PGK2 is also involved in the phosphorylation of various substrates, including proteins, lipids, and carbohydrates. **Clinical significance:** * Mutations in the PGK2 gene have been linked to several human diseases, including cancer, diabetes, and heart disease. * In cancer, mutations in PGK2 are often associated with the development of drug resistance and impaired response to therapy. * Targeting PGK2 has emerged as a promising therapeutic strategy for the treatment of cancer and other diseases associated with PGK2 mutations.

Genular Protein ID: 719043473

Symbol: PGK2_HUMAN

Name: Phosphoglycerate kinase 2

UniProtKB Accession Codes:

P07205 B2R6Y8 Q9H107

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3453121

Title: Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.

PubMed ID: 3453121

DOI: 10.1038/326501a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26677959

Title: Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality.

PubMed ID: 26677959

DOI: 10.1093/humrep/dev301

Sequence Information:

  • Length: 417
  • Mass: 44796
  • Checksum: 0CD5C71C2D3A9272
  • Sequence:
    • MSLSKKLTLD KLDVRGKRVI MRVDFNVPMK KNQITNNQRI KASIPSIKYC LDNGAKAVVL 
MSHLGRPDGV PMPDKYSLAP VAVELKSLLG KDVLFLKDCV GAEVEKACAN PAPGSVILLE 
NLRFHVEEEG KGQDPSGKKI KAEPDKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN 
LPHKASGFLM KKELDYFAKA LENPVRPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM 
AYTFLKVLNN MEIGASLFDE EGAKIVKDIM AKAQKNGVRI TFPVDFVTGD KFDENAQVGK 
ATVASGISPG WMGLDCGPES NKNHAQVVAQ ARLIVWNGPL GVFEWDAFAK GTKALMDEIV 
KATSKGCITV IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKILPG VEALSNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.