Details for: PNMT

Gene ID: 5409

Symbol: PNMT

Ensembl ID: ENSG00000141744

Description: phenylethanolamine N-methyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.75
    Marker Score: 1189
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.34
    Marker Score: 442
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18353.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.91
    Marker Score: 570
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.91
    Marker Score: 969
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.85
    Marker Score: 639
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.84
    Marker Score: 569
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.83
    Marker Score: 344.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.8
    Marker Score: 2045
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 369.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.73
    Marker Score: 757
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 554
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.72
    Marker Score: 1046
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.71
    Marker Score: 289
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.67
    Marker Score: 569
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.66
    Marker Score: 570
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 774
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.56
    Marker Score: 977
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.55
    Marker Score: 1347
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.5
    Marker Score: 128
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.46
    Marker Score: 162
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.43
    Marker Score: 214
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.41
    Marker Score: 218
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.39
    Marker Score: 811
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 356
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.36
    Marker Score: 77
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.33
    Marker Score: 327
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.32
    Marker Score: 568
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.32
    Marker Score: 1227
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.31
    Marker Score: 61
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.29
    Marker Score: 2918
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.29
    Marker Score: 69
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.28
    Marker Score: 216
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.27
    Marker Score: 137
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 100
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.25
    Marker Score: 118
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 220
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.24
    Marker Score: 304
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.23
    Marker Score: 466.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.23
    Marker Score: 814
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.23
    Marker Score: 329
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.21
    Marker Score: 152
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.19
    Marker Score: 323
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.19
    Marker Score: 585
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.18
    Marker Score: 75
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.18
    Marker Score: 1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.17
    Marker Score: 3892
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.17
    Marker Score: 261
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.17
    Marker Score: 152
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.17
    Marker Score: 246
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.16
    Marker Score: 168
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 336
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.14
    Marker Score: 110
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 82

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Other Information

**Key Characteristics:** PNMT is a soluble enzyme that belongs to the methyltransferase family. It is primarily expressed in the sympathetic nervous system, where it plays a critical role in the regulation of catecholamine levels. The enzyme has a high affinity for its substrate, epinephrine, and is highly specific for this substrate, making it an essential component of the catecholamine biosynthetic pathway. PNMT is also found in other tissues, including the heart, adrenal glands, and brain, where it contributes to the regulation of various physiological processes. **Pathways and Functions:** PNMT is involved in the following pathways: 1. **Catecholamine biosynthesis:** PNMT catalyzes the conversion of epinephrine to norepinephrine, a step that is essential for the production of these neurotransmitters. 2. **Epinephrine biosynthetic process:** PNMT is involved in the regulation of epinephrine levels, which is critical for the body's response to stress, exercise, and other physiological stimuli. 3. **Metabolism of amine-derived hormones:** PNMT plays a role in the regulation of the metabolism of amine-derived hormones, including catecholamines and serotonin. 4. **Methylation:** PNMT is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAMe) to epinephrine, resulting in the formation of norepinephrine. **Clinical Significance:** Dysregulation of PNMT has been implicated in various diseases and disorders, including: 1. **Hypertension:** Increased PNMT activity has been linked to elevated blood pressure, as it contributes to the production of norepinephrine, a potent vasoconstrictor. 2. **Neurodegenerative diseases:** Alterations in PNMT expression have been observed in neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, suggesting a potential role in the pathogenesis of these disorders. 3. **Cancer:** PNMT has been implicated in the regulation of cancer cell growth and metastasis, highlighting its potential as a therapeutic target. In conclusion, PNMT is a critical enzyme involved in the biosynthesis of catecholamines, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the mechanisms by which PNMT regulates catecholamine levels and to explore its potential as a therapeutic target.

Genular Protein ID: 1838937436

Symbol: PNMT_HUMAN

Name: Phenylethanolamine N-methyltransferase

UniProtKB Accession Codes:

P11086

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 30 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 16 DrugCentral 1 EC 2 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 48 PDBsum 44 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3372503

Title: Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis.

PubMed ID: 3372503

DOI: 10.1016/s0021-9258(18)68551-5

PubMed ID: 2835776

Title: Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.

PubMed ID: 2835776

DOI: 10.1073/pnas.85.10.3648

PubMed ID: 8812853

Title: Recombinant human phenylethanolamine N-methyltransferase: overproduction in Escherichia coli, purification, and characterization.

PubMed ID: 8812853

DOI: 10.1006/prep.1996.0088

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20496117

Title: Discovery of novel human phenylethanolamine N-methyltransferase (hPNMT) inhibitors using 3D pharmacophore-based in silico, biophysical screening and enzymatic activity assays.

PubMed ID: 20496117

DOI: 10.1007/s10059-010-0074-3

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11591352

Title: Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.

PubMed ID: 11591352

DOI: 10.1016/s0969-2126(01)00662-1

PubMed ID: 16363801

Title: Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.

PubMed ID: 16363801

DOI: 10.1021/bi051636b

PubMed ID: 16942016

Title: Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

PubMed ID: 16942016

DOI: 10.1021/jm060466d

PubMed ID: 17845018

Title: Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

PubMed ID: 17845018

DOI: 10.1021/jm0703385

PubMed ID: 16277617

Title: Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics.

PubMed ID: 16277617

DOI: 10.1111/j.1471-4159.2005.03453.x

Sequence Information:

  • Length: 282
  • Mass: 30855
  • Checksum: 56F3A9981D9ABF4C
  • Sequence:
    • MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC 
LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA 
FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS 
AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR 
EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL

Genular Protein ID: 4278877786

Symbol: A8MT87_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MT87

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 184
  • Mass: 20560
  • Checksum: 55187EBFB3EB9C0C
  • Sequence:
    • MTDFLEVNRQ ELGRWLQEEP GAFNWSMYSQ HACLIEGKGE CWQDKERQLR ARVKRVLPID 
VHQPQPLGAG SPAPLPADAL VSAFCLEAVS PDLASFQRAL DHITTLLRPG GHLLLIGALE 
ESWYLAGEAR LTVVPVSEEE VREALVRSGY KVRDLRTYIM PAHLQTGVDD VKGVFFAWAQ 
KVGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.