Details for: SAGE1

Gene ID: 55511

Symbol: SAGE1

Ensembl ID: ENSG00000181433

Description: sarcoma antigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.6327
    Cell Significance Index: 12.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4960
    Cell Significance Index: 7.2300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1360
    Cell Significance Index: 1.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1036
    Cell Significance Index: 0.8900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0901
    Cell Significance Index: 0.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0853
    Cell Significance Index: 1.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0695
    Cell Significance Index: 1.0000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0407
    Cell Significance Index: 0.4600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0225
    Cell Significance Index: 0.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0204
    Cell Significance Index: 0.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0126
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0032
    Cell Significance Index: 0.5400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0005
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0009
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0025
    Cell Significance Index: -0.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0031
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0039
    Cell Significance Index: -0.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0055
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0059
    Cell Significance Index: -0.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0063
    Cell Significance Index: -0.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0071
    Cell Significance Index: -0.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0075
    Cell Significance Index: -0.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0103
    Cell Significance Index: -0.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0103
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0110
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0112
    Cell Significance Index: -0.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0116
    Cell Significance Index: -0.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0122
    Cell Significance Index: -0.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0128
    Cell Significance Index: -0.2800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0128
    Cell Significance Index: -0.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0128
    Cell Significance Index: -0.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0129
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0129
    Cell Significance Index: -0.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0130
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0131
    Cell Significance Index: -0.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0131
    Cell Significance Index: -0.5400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0137
    Cell Significance Index: -0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0138
    Cell Significance Index: -0.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0140
    Cell Significance Index: -0.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0142
    Cell Significance Index: -0.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0142
    Cell Significance Index: -0.2100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0150
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0151
    Cell Significance Index: -0.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0154
    Cell Significance Index: -0.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0156
    Cell Significance Index: -0.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0160
    Cell Significance Index: -0.1700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0167
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0168
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0168
    Cell Significance Index: -0.2300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0171
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0178
    Cell Significance Index: -0.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0179
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0188
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0189
    Cell Significance Index: -0.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0195
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0196
    Cell Significance Index: -0.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0215
    Cell Significance Index: -0.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0217
    Cell Significance Index: -0.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0218
    Cell Significance Index: -0.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0222
    Cell Significance Index: -0.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0224
    Cell Significance Index: -0.2800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SAGE1 is significantly expressed in a diverse range of cell types, including progenitor cells, endothelial cells, T cells, plasma cells, B cells, goblet cells, and stem cells from various tissues. 2. **Pathway Involvement:** SAGE1 is integrated into the integrator complex pathway, which regulates gene expression and cellular differentiation. 3. **Protein Function:** The protein encoded by SAGE1, SAGE1_HUMAN, is a transcriptional regulator that modulates gene expression and cellular processes. **Pathways and Functions:** 1. **Integrator Complex Pathway:** SAGE1 is a key component of the integrator complex, a multifunctional complex that regulates gene expression and cellular differentiation. The integrator complex is involved in the processing of snRNA and the regulation of gene expression in response to cellular stress. 2. **SnRNA 3'-End Processing:** SAGE1 is also involved in the processing of snRNA, specifically the 3'-end processing of snRNA, which is essential for the regulation of gene expression and cellular differentiation. 3. **Cellular Differentiation:** SAGE1 regulates cellular differentiation by modulating gene expression and cellular processes, such as proliferation and survival. 4. **Immune Response:** SAGE1 plays a role in the immune response, particularly in the regulation of T cell and B cell function. **Clinical Significance:** 1. **Cancer Association:** SAGE1 has been implicated in various cancers, including sarcomas, where it is often overexpressed. 2. **Immune-Related Disorders:** SAGE1 may play a role in immune-related disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Regenerative Medicine:** SAGE1's involvement in tissue regeneration and stem cell function makes it a potential target for regenerative medicine applications. 4. **Diagnostic and Therapeutic Potential:** Further research is needed to fully elucidate the clinical significance of SAGE1, but its potential as a diagnostic and therapeutic target is an area of active investigation. In conclusion, SAGE1 is a gene of significant interest in the realm of immunology and tissue regeneration. Its involvement in the integrator complex pathway, snRNA 3'-end processing, and cellular differentiation underscores its importance in regulating gene expression and cellular processes. Further research is needed to fully elucidate the clinical significance of SAGE1, but its potential as a diagnostic and therapeutic target is an area of active investigation.

Genular Protein ID: 894274950

Symbol: SAGE1_HUMAN

Name: Sarcoma antigen 1

UniProtKB Accession Codes:

Q9NXZ1 Q5JNW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10919659

Title: Identification on a human sarcoma of two new genes with tumor-specific expression.

PubMed ID: 10919659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 904
  • Mass: 99225
  • Checksum: 0537E3F0E1858CE5
  • Sequence:
    • MQASPLQTSQ PTPPEELHAA AYVFTNDGQQ MRSDEVNLVA TGHQSKKKHS RKSKRHSSSK 
RRKSMSSWLD KQEDAAVTHS ICEERINNGQ PVADNVLSTA PPWPDATIAH NIREERMENG 
QSRTDKVLST APPQLVHMAA AGIPSMSTRD LHSTVTHNIR EERMENGQPQ PDNVLSTGPT 
GLINMAATPI PAMSARDLYA TVTHNVCEQK MENVQPAPDN VLLTLRPRRI NMTDTGISPM 
STRDPYATIT YNVPEEKMEK GQPQPDNILS TASTGLINVA GAGTPAISTN GLYSTVPHNV 
CEEKMENDQP QPNNVLSTVQ PVIIYLTATG IPGMNTRDQY ATITHNVCEE RVVNNQPLPS 
NALSTVLPGL AYLATADMPA MSTRDQHATI IHNLREEKKD NSQPTPDNVL SAVTPELINL 
AGAGIPPMST RDQYATVNHH VHEARMENGQ RKQDNVLSNV LSGLINMAGA SIPAMSSRDL 
YATITHSVRE EKMESGKPQT DKVISNDAPQ LGHMAAGGIP SMSTKDLYAT VTQNVHEERM 
ENNQPQPSYD LSTVLPGLTY LTVAGIPAMS TRDQYATVTH NVHEEKIKNG QAASDNVFST 
VPPAFINMAA TGVSSMSTRD QYAAVTHNIR EEKINNSQPA PGNILSTAPP WLRHMAAAGI 
SSTITRDLYV TATHSVHEEK MTNGQQAPDN SLSTVPPGCI NLSGAGISCR STRDLYATVI 
HDIQEEEMEN DQTPPDGFLS NSDSPELINM TGHCMPPNAL DSFSHDFTSL SKDELLYKPD 
SNEFAVGTKN YSVSAGDPPV TVMSLVETVP NTPQISPAMA KKINDDIKYQ LMKEVRRFGQ 
NYERIFILLE EVQGSMKVKR QFVEFTIKEA ARFKKVVLIQ QLEKALKEID SHCHLRKVKH 
MRKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.