Details for: PROP1

Gene ID: 5626

Symbol: PROP1

Ensembl ID: ENSG00000175325

Description: PROP paired-like homeobox 1

Associated with

  • Apoptotic process
    (GO:0006915)
  • Beta-catenin binding
    (GO:0008013)
  • Blood vessel development
    (GO:0001568)
  • Cell migration
    (GO:0016477)
  • Central nervous system development
    (GO:0007417)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dorsal/ventral pattern formation
    (GO:0009953)
  • Hypophysis morphogenesis
    (GO:0048850)
  • Hypothalamus cell differentiation
    (GO:0021979)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatotropin secreting cell differentiation
    (GO:0060126)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.0891
    Cell Significance Index: 79.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.4534
    Cell Significance Index: 37.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6337
    Cell Significance Index: 8.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4627
    Cell Significance Index: 7.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2923
    Cell Significance Index: 6.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2698
    Cell Significance Index: 4.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1591
    Cell Significance Index: 1.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1089
    Cell Significance Index: 1.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0930
    Cell Significance Index: 1.3600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0673
    Cell Significance Index: 0.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0184
    Cell Significance Index: 6.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0174
    Cell Significance Index: 0.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0085
    Cell Significance Index: 0.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0059
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0046
    Cell Significance Index: 0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0043
    Cell Significance Index: 0.1100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0003
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0018
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0031
    Cell Significance Index: -0.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0037
    Cell Significance Index: -0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0046
    Cell Significance Index: -0.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0048
    Cell Significance Index: -0.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0049
    Cell Significance Index: -0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0058
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0060
    Cell Significance Index: -0.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0063
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0066
    Cell Significance Index: -0.8100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0073
    Cell Significance Index: -0.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0079
    Cell Significance Index: -0.3500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0079
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0085
    Cell Significance Index: -0.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0092
    Cell Significance Index: -0.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0129
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0180
    Cell Significance Index: -0.4800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0183
    Cell Significance Index: -0.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0193
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0198
    Cell Significance Index: -0.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0202
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0207
    Cell Significance Index: -0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0224
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0229
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0234
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0237
    Cell Significance Index: -0.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0237
    Cell Significance Index: -0.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0249
    Cell Significance Index: -0.2700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0252
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0259
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0262
    Cell Significance Index: -0.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0266
    Cell Significance Index: -0.4500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0274
    Cell Significance Index: -0.3100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0280
    Cell Significance Index: -0.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0281
    Cell Significance Index: -0.3800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0288
    Cell Significance Index: -0.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0289
    Cell Significance Index: -0.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0293
    Cell Significance Index: -0.3700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0295
    Cell Significance Index: -0.2600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0304
    Cell Significance Index: -0.3500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0307
    Cell Significance Index: -0.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0312
    Cell Significance Index: -0.4100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0316
    Cell Significance Index: -0.4500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0317
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0320
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: PROP1 is a transcription factor that regulates gene expression by binding to specific DNA sequences and interacting with RNA polymerase II. 2. **Developmental involvement**: The PROP1 gene is involved in various developmental processes, including blood vessel development, central nervous system development, and somatotropin secretion. 3. **Cell-type specificity**: PROP1 is significantly expressed in multiple cell types, including progenitor cells, endothelial cells, and specific neuronal populations. 4. **Apoptotic regulation**: PROP1 has been shown to regulate the apoptotic process, suggesting its role in cell survival and death. **Pathways and Functions:** 1. **Apoptotic process**: PROP1 regulates the apoptotic process by interacting with pro-apoptotic and anti-apoptotic proteins, thereby modulating cell survival and death. 2. **Transcriptional regulation**: PROP1 regulates gene expression by binding to specific DNA sequences and interacting with RNA polymerase II, leading to the activation or repression of target genes. 3. **Blood vessel development**: PROP1 is involved in blood vessel development, suggesting its role in angiogenesis and vascular remodeling. 4. **Central nervous system development**: PROP1 is involved in central nervous system development, including the differentiation of specific neuronal populations and the regulation of synaptic plasticity. 5. **Somatotropin secretion**: PROP1 regulates somatotropin secretion, which is essential for growth and development. **Clinical Significance:** 1. **Diabetes**: Mutations in the PROP1 gene have been associated with autoimmune diabetes, specifically type 1 diabetes, suggesting its role in immune system regulation and autoimmunity. 2. **Hypopituitarism**: PROP1 is involved in the development and function of the hypothalamus and pituitary gland, and mutations in this gene can lead to hypopituitarism, a disorder characterized by impaired hormone production. 3. **Neurological disorders**: PROP1 has been implicated in various neurological disorders, including schizophrenia, autism, and Alzheimer's disease, suggesting its role in brain development and function. 4. **Cancer**: PROP1 has been shown to regulate cell proliferation and apoptosis in certain cancer types, suggesting its potential as a therapeutic target. In conclusion, the PROP1 gene is a transcription factor that plays a crucial role in various developmental processes and cellular functions. Its involvement in apoptosis, transcriptional regulation, blood vessel development, central nervous system development, and somatotropin secretion highlights its importance in human health and disease. Further research is needed to fully understand the role of PROP1 in human biology and disease.

Genular Protein ID: 1863555675

Symbol: PROP1_HUMAN

Name: Homeobox protein prophet of Pit-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9824293

Title: Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency.

PubMed ID: 9824293

DOI: 10.1016/s0014-5793(98)01234-4

PubMed ID: 9462743

Title: Mutations in PROP1 cause familial combined pituitary hormone deficiency.

PubMed ID: 9462743

DOI: 10.1038/ng0298-147

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9768691

Title: Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C).

PubMed ID: 9768691

DOI: 10.1210/jcem.83.10.5172

PubMed ID: 10946881

Title: Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1.

PubMed ID: 10946881

DOI: 10.1210/jcem.85.8.6744

PubMed ID: 11549703

Title: PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency.

PubMed ID: 11549703

DOI: 10.1210/jcem.86.9.7811

PubMed ID: 12519826

Title: Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay.

PubMed ID: 12519826

DOI: 10.1210/jc.2001-011872

PubMed ID: 15531542

Title: A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.

PubMed ID: 15531542

DOI: 10.1210/jc.2003-032124

PubMed ID: 19128366

Title: Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD).

PubMed ID: 19128366

DOI: 10.1111/j.1365-2265.2008.03326.x

Sequence Information:

  • Length: 226
  • Mass: 24984
  • Checksum: CE6D59B3D295A86D
  • Sequence:
  • MEAERRRQAE KPKKGRVGSN LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG 
    GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR 
    RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS 
    TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN

Genular Protein ID: 1317479259

Symbol: A0A0G2JQ02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 226
  • Mass: 24957
  • Checksum: D04A7C60F5B07DB4
  • Sequence:
  • MEAERRRQAE KPKKGRVGSS LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG 
    GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR 
    RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS 
    TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.