Details for: PROP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 4.0891
Cell Significance Index: 79.9500 - Cell Name: erythrocyte (CL0000232)
Fold Change: 1.4534
Cell Significance Index: 37.0300 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.6337
Cell Significance Index: 8.6900 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.4627
Cell Significance Index: 7.9100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2923
Cell Significance Index: 6.4000 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2698
Cell Significance Index: 4.3700 - Cell Name: progenitor cell (CL0011026)
Fold Change: 0.1591
Cell Significance Index: 1.6900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1089
Cell Significance Index: 1.5600 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.0930
Cell Significance Index: 1.3600 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.0673
Cell Significance Index: 0.7100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0327
Cell Significance Index: 0.5600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0184
Cell Significance Index: 6.5900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0174
Cell Significance Index: 0.3500 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0085
Cell Significance Index: 0.1100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0059
Cell Significance Index: 0.0800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0046
Cell Significance Index: 0.9200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0043
Cell Significance Index: 0.1100 - Cell Name: adipocyte (CL0000136)
Fold Change: 0.0026
Cell Significance Index: 0.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0003
Cell Significance Index: 0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0000
Cell Significance Index: -0.0400 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0002
Cell Significance Index: -0.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0002
Cell Significance Index: -0.2600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0003
Cell Significance Index: -0.4100 - Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0004
Cell Significance Index: 0.0000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0007
Cell Significance Index: -0.5600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0012
Cell Significance Index: -0.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0014
Cell Significance Index: -0.8900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0018
Cell Significance Index: -0.8100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0018
Cell Significance Index: -0.3500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0031
Cell Significance Index: -0.4200 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.0034
Cell Significance Index: -0.0400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0037
Cell Significance Index: -0.5400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0046
Cell Significance Index: -0.8300 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0048
Cell Significance Index: -0.0700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0049
Cell Significance Index: -0.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0058
Cell Significance Index: -0.1600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0059
Cell Significance Index: -0.1600 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0060
Cell Significance Index: -0.1900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0063
Cell Significance Index: -0.1700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0066
Cell Significance Index: -0.8100 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0066
Cell Significance Index: -0.0800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0068
Cell Significance Index: -0.1700 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0069
Cell Significance Index: -0.1000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0073
Cell Significance Index: -0.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0079
Cell Significance Index: -0.3500 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0079
Cell Significance Index: -0.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0080
Cell Significance Index: -0.4500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0085
Cell Significance Index: -0.2700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0090
Cell Significance Index: -0.1900 - Cell Name: mast cell (CL0000097)
Fold Change: -0.0091
Cell Significance Index: -0.1200 - Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0092
Cell Significance Index: -0.1200 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.0092
Cell Significance Index: -0.0900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0092
Cell Significance Index: -0.3500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0102
Cell Significance Index: -0.2000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0105
Cell Significance Index: -0.2100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0108
Cell Significance Index: -0.2700 - Cell Name: neuron (CL0000540)
Fold Change: -0.0116
Cell Significance Index: -0.1100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0120
Cell Significance Index: -0.2600 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0126
Cell Significance Index: -0.1200 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0129
Cell Significance Index: -0.2700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0152
Cell Significance Index: -0.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0180
Cell Significance Index: -0.4800 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0183
Cell Significance Index: -0.2400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0193
Cell Significance Index: -0.4700 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0198
Cell Significance Index: -0.3000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0202
Cell Significance Index: -0.4900 - Cell Name: acinar cell (CL0000622)
Fold Change: -0.0207
Cell Significance Index: -0.2600 - Cell Name: malignant cell (CL0001064)
Fold Change: -0.0224
Cell Significance Index: -0.1200 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0229
Cell Significance Index: -0.2500 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0229
Cell Significance Index: -0.3900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0234
Cell Significance Index: -0.3500 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0237
Cell Significance Index: -0.4100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0237
Cell Significance Index: -0.4000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0238
Cell Significance Index: -0.2800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0244
Cell Significance Index: -0.3600 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0249
Cell Significance Index: -0.2700 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0252
Cell Significance Index: -0.3400 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: -0.0259
Cell Significance Index: -0.2800 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.0262
Cell Significance Index: -0.2600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0266
Cell Significance Index: -0.2800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0266
Cell Significance Index: -0.4500 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0274
Cell Significance Index: -0.3100 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.0280
Cell Significance Index: -0.3600 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0281
Cell Significance Index: -0.3800 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0288
Cell Significance Index: -0.2800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0289
Cell Significance Index: -0.5600 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0293
Cell Significance Index: -0.3700 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.0295
Cell Significance Index: -0.2600 - Cell Name: chondrocyte (CL0000138)
Fold Change: -0.0304
Cell Significance Index: -0.3500 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.0307
Cell Significance Index: -0.3200 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0310
Cell Significance Index: -0.4300 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0312
Cell Significance Index: -0.4100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0314
Cell Significance Index: -0.3800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0316
Cell Significance Index: -0.4500 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0317
Cell Significance Index: -0.4000 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0317
Cell Significance Index: -0.5100 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0318
Cell Significance Index: -0.5400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0320
Cell Significance Index: -0.4600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1863555675
Symbol: PROP1_HUMAN
Name: Homeobox protein prophet of Pit-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9824293
Title: Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency.
PubMed ID: 9824293
PubMed ID: 9462743
Title: Mutations in PROP1 cause familial combined pituitary hormone deficiency.
PubMed ID: 9462743
DOI: 10.1038/ng0298-147
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9768691
Title: Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C).
PubMed ID: 9768691
PubMed ID: 10946881
Title: Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1.
PubMed ID: 10946881
PubMed ID: 11549703
Title: PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency.
PubMed ID: 11549703
PubMed ID: 12519826
Title: Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay.
PubMed ID: 12519826
PubMed ID: 15531542
Title: A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.
PubMed ID: 15531542
PubMed ID: 19128366
Title: Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD).
PubMed ID: 19128366
Sequence Information:
- Length: 226
- Mass: 24984
- Checksum: CE6D59B3D295A86D
- Sequence:
MEAERRRQAE KPKKGRVGSN LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN
Genular Protein ID: 1317479259
Symbol: A0A0G2JQ02_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 226
- Mass: 24957
- Checksum: D04A7C60F5B07DB4
- Sequence:
MEAERRRQAE KPKKGRVGSS LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.