Details for: TMPRSS15

Gene ID: 5651

Symbol: TMPRSS15

Ensembl ID: ENSG00000154646

Description: transmembrane serine protease 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 14.6953
    Cell Significance Index: 111.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6769
    Cell Significance Index: 105.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.4432
    Cell Significance Index: 74.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3162
    Cell Significance Index: 250.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.1643
    Cell Significance Index: 16.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9050
    Cell Significance Index: 54.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6788
    Cell Significance Index: 30.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5686
    Cell Significance Index: 18.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5508
    Cell Significance Index: 11.7300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.5291
    Cell Significance Index: 6.7000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.5234
    Cell Significance Index: 4.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5171
    Cell Significance Index: 12.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4761
    Cell Significance Index: 51.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3904
    Cell Significance Index: 352.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3435
    Cell Significance Index: 7.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3194
    Cell Significance Index: 4.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3146
    Cell Significance Index: 21.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2910
    Cell Significance Index: 28.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2462
    Cell Significance Index: 4.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1862
    Cell Significance Index: 30.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1379
    Cell Significance Index: 3.0200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1378
    Cell Significance Index: 0.9700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1359
    Cell Significance Index: 1.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0756
    Cell Significance Index: 1.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0705
    Cell Significance Index: 1.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0425
    Cell Significance Index: 1.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0273
    Cell Significance Index: 18.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0236
    Cell Significance Index: 0.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0233
    Cell Significance Index: 1.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0161
    Cell Significance Index: 3.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0146
    Cell Significance Index: 2.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0123
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0055
    Cell Significance Index: 0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0036
    Cell Significance Index: 0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 3.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 3.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0008
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0035
    Cell Significance Index: -2.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -2.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0081
    Cell Significance Index: -0.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0114
    Cell Significance Index: -0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0115
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0159
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0172
    Cell Significance Index: -1.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0192
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0215
    Cell Significance Index: -2.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0220
    Cell Significance Index: -0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0230
    Cell Significance Index: -1.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0248
    Cell Significance Index: -1.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0259
    Cell Significance Index: -0.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0271
    Cell Significance Index: -2.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0321
    Cell Significance Index: -3.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0327
    Cell Significance Index: -0.8400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0384
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0384
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0427
    Cell Significance Index: -0.2900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0442
    Cell Significance Index: -0.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0455
    Cell Significance Index: -2.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0529
    Cell Significance Index: -2.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0543
    Cell Significance Index: -2.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0545
    Cell Significance Index: -1.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0602
    Cell Significance Index: -2.1100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0613
    Cell Significance Index: -0.3800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0633
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0673
    Cell Significance Index: -2.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0678
    Cell Significance Index: -2.2200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0680
    Cell Significance Index: -0.4200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0693
    Cell Significance Index: -0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0757
    Cell Significance Index: -2.0200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0763
    Cell Significance Index: -0.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0892
    Cell Significance Index: -1.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0902
    Cell Significance Index: -2.2000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0933
    Cell Significance Index: -1.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0958
    Cell Significance Index: -0.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1000
    Cell Significance Index: -2.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1001
    Cell Significance Index: -2.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1017
    Cell Significance Index: -2.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1046
    Cell Significance Index: -2.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1049
    Cell Significance Index: -1.0700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1056
    Cell Significance Index: -1.5800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1068
    Cell Significance Index: -0.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1088
    Cell Significance Index: -2.3500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1088
    Cell Significance Index: -1.4800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1090
    Cell Significance Index: -1.4700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1106
    Cell Significance Index: -1.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1110
    Cell Significance Index: -2.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1122
    Cell Significance Index: -4.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1129
    Cell Significance Index: -1.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1166
    Cell Significance Index: -2.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1181
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMPRSS15 exhibits several key characteristics that distinguish it from other serine proteases: 1. **Membrane-bound enzyme**: TMPRSS15 is embedded in the cell membrane, allowing it to interact with its substrates in a spatially controlled manner. 2. **Serine protease activity**: The gene encodes a serine protease domain, which is responsible for catalyzing the hydrolysis of peptide bonds. 3. **High expression levels**: TMPRSS15 is highly expressed in multiple cell types, suggesting its importance in various physiological processes. 4. **Multiple substrates**: TMPRSS15 has been shown to cleave various substrates, including proteolytic enzymes, cytokines, and growth factors. **Pathways and Functions** TMPRSS15 plays a significant role in several biological pathways, including: 1. **Proteolysis**: TMPRSS15 is involved in the regulation of proteolytic processes, influencing the activation of proteolytic enzymes and the cleavage of growth factors. 2. **Immune responses**: TMPRSS15 has been shown to modulate immune responses by cleaving cytokines and growth factors, influencing the activation and regulation of immune cells. 3. **Cell signaling**: TMPRSS15 interacts with various growth factors and cytokines, influencing cellular signaling pathways and tissue homeostasis. 4. **Tissue homeostasis**: TMPRSS15 is involved in the regulation of tissue homeostasis, influencing the turnover of epithelial cells and the maintenance of tissue architecture. **Clinical Significance** TMPRSS15 has been implicated in various diseases, including: 1. **Cancer**: TMPRSS15 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role as a diagnostic biomarker. 2. **Inflammatory disorders**: TMPRSS15 has been implicated in inflammatory disorders, including atherosclerosis and rheumatoid arthritis, highlighting its potential role in modulating immune responses. 3. **Cardiovascular disease**: TMPRSS15 has been shown to be involved in cardiovascular disease, including atherosclerosis and cardiac dysfunction. 4. **Neurological disorders**: TMPRSS15 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in modulating cellular signaling pathways. In conclusion, TMPRSS15 is a multifunctional serine protease that plays a critical role in various physiological processes, including proteolysis, immune responses, cell signaling, and tissue homeostasis. Its involvement in various diseases highlights the potential for TMPRSS15 as a therapeutic target and diagnostic biomarker.

Genular Protein ID: 4006208978

Symbol: ENTK_HUMAN

Name: Enteropeptidase

UniProtKB Accession Codes:

P98073 Q2NKL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 24 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 10 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 6 SMR 1 STRING 1 SUPFAM 6 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7718557

Title: cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen.

PubMed ID: 7718557

DOI: 10.1021/bi00014a008

PubMed ID: 11719902

Title: Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency.

PubMed ID: 11719902

DOI: 10.1086/338456

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8052624

Title: Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.

PubMed ID: 8052624

DOI: 10.1073/pnas.91.16.7588

PubMed ID: 22488687

Title: Crystal structure of a supercharged variant of the human enteropeptidase light chain.

PubMed ID: 22488687

DOI: 10.1002/prot.24084

Sequence Information:

  • Length: 1019
  • Mass: 112935
  • Checksum: 45288F0636E5EC52
  • Sequence:
    • MGSKRGISSR HHSLSSYEIM FAALFAILVV LCAGLIAVSC LTIKESQRGA ALGQSHEARA 
TFKITSGVTY NPNLQDKLSV DFKVLAFDLQ QMIDEIFLSS NLKNEYKNSR VLQFENGSII 
VVFDLFFAQW VSDENVKEEL IQGLEANKSS QLVTFHIDLN SVDILDKLTT TSHLATPGNV 
SIECLPGSSP CTDALTCIKA DLFCDGEVNC PDGSDEDNKM CATVCDGRFL LTGSSGSFQA 
THYPKPSETS VVCQWIIRVN QGLSIKLSFD DFNTYYTDIL DIYEGVGSSK ILRASIWETN 
PGTIRIFSNQ VTATFLIESD ESDYVGFNAT YTAFNSSELN NYEKINCNFE DGFCFWVQDL 
NDDNEWERIQ GSTFSPFTGP NFDHTFGNAS GFYISTPTGP GGRQERVGLL SLPLDPTLEP 
ACLSFWYHMY GENVHKLSIN ISNDQNMEKT VFQKEGNYGD NWNYGQVTLN ETVKFKVAFN 
AFKNKILSDI ALDDISLTYG ICNGSLYPEP TLVPTPPPEL PTDCGGPFEL WEPNTTFSST 
NFPNSYPNLA FCVWILNAQK GKNIQLHFQE FDLENINDVV EIRDGEEADS LLLAVYTGPG 
PVKDVFSTTN RMTVLLITND VLARGGFKAN FTTGYHLGIP EPCKADHFQC KNGECVPLVN 
LCDGHLHCED GSDEADCVRF FNGTTNNNGL VRFRIQSIWH TACAENWTTQ ISNDVCQLLG 
LGSGNSSKPI FPTDGGPFVK LNTAPDGHLI LTPSQQCLQD SLIRLQCNHK SCGKKLAAQD 
ITPKIVGGSN AKEGAWPWVV GLYYGGRLLC GASLVSSDWL VSAAHCVYGR NLEPSKWTAI 
LGLHMKSNLT SPQTVPRLID EIVINPHYNR RRKDNDIAMM HLEFKVNYTD YIQPICLPEE 
NQVFPPGRNC SIAGWGTVVY QGTTANILQE ADVPLLSNER CQQQMPEYNI TENMICAGYE 
EGGIDSCQGD SGGPLMCQEN NRWFLAGVTS FGYKCALPNR PGVYARVSRF TEWIQSFLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.