Details for: IFNK

Gene ID: 56832

Symbol: IFNK

Ensembl ID: ENSG00000147896

Description: interferon kappa

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.2990
    Cell Significance Index: 1.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1481
    Cell Significance Index: 2.0200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0919
    Cell Significance Index: 0.9700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0635
    Cell Significance Index: 0.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0634
    Cell Significance Index: 1.7000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0627
    Cell Significance Index: 0.6400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0406
    Cell Significance Index: 0.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0272
    Cell Significance Index: 0.4400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0246
    Cell Significance Index: 0.3400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.0239
    Cell Significance Index: 0.1900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0184
    Cell Significance Index: 0.1100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0177
    Cell Significance Index: 0.2700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0177
    Cell Significance Index: 0.1900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.0164
    Cell Significance Index: 0.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0152
    Cell Significance Index: 0.3100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0144
    Cell Significance Index: 0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0137
    Cell Significance Index: 0.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0110
    Cell Significance Index: 0.0900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0099
    Cell Significance Index: 0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0062
    Cell Significance Index: 0.3800
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.0060
    Cell Significance Index: 0.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0044
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0036
    Cell Significance Index: 0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0035
    Cell Significance Index: 0.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0010
    Cell Significance Index: 0.1100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0008
    Cell Significance Index: 0.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0023
    Cell Significance Index: -0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0026
    Cell Significance Index: -0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0028
    Cell Significance Index: -0.5100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0034
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0047
    Cell Significance Index: -0.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0062
    Cell Significance Index: -0.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0063
    Cell Significance Index: -0.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0069
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0086
    Cell Significance Index: -0.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0117
    Cell Significance Index: -0.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0119
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0126
    Cell Significance Index: -0.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0126
    Cell Significance Index: -0.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0127
    Cell Significance Index: -0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0128
    Cell Significance Index: -0.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0152
    Cell Significance Index: -0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0168
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0173
    Cell Significance Index: -0.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0183
    Cell Significance Index: -0.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0185
    Cell Significance Index: -0.4600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0196
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0209
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0212
    Cell Significance Index: -0.2400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0213
    Cell Significance Index: -0.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0221
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0233
    Cell Significance Index: -0.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0235
    Cell Significance Index: -0.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0237
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0239
    Cell Significance Index: -0.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0250
    Cell Significance Index: -0.6100
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0250
    Cell Significance Index: -0.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0255
    Cell Significance Index: -0.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0264
    Cell Significance Index: -0.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0266
    Cell Significance Index: -0.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0271
    Cell Significance Index: -0.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0271
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0273
    Cell Significance Index: -0.3800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0274
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0283
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0284
    Cell Significance Index: -0.5700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0286
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0287
    Cell Significance Index: -0.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0293
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0293
    Cell Significance Index: -0.5800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0307
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IFNK is a single-stranded RNA molecule, which is a hallmark of interferons. 2. **Function:** IFNK is a type I interferon, which means it binds to the type I interferon receptor (IFNAR) on the surface of target cells, triggering a signaling cascade that regulates immune responses. 3. **Expression:** IFNK is expressed in various cell types, including progenitor cells, endothelial cells, and immune cells, such as natural killer cells and T cells. 4. **Regulation:** IFNK is regulated by various factors, including viral infections, cytokines, and growth factors. **Pathways and Functions:** 1. **Adaptive Immune Response:** IFNK is involved in the regulation of B cell differentiation, proliferation, and activation, which are essential for the humoral immune response. 2. **Innate Immune Response:** IFNK is a key player in the innate immune response against viral infections, triggering the production of antiviral proteins and modulating the activity of immune cells. 3. **Cytokine-Mediated Signaling Pathway:** IFNK binds to the type I interferon receptor, triggering a signaling cascade that regulates the expression of genes involved in immune responses. 4. **Negative Regulation of Cell Population Proliferation:** IFNK can also regulate the proliferation of cells, including immune cells, by inhibiting the expression of genes involved in cell growth and proliferation. **Clinical Significance:** 1. **Viral Infections:** IFNK plays a crucial role in the regulation of immune responses against viral infections, such as herpes simplex virus and influenza virus. 2. **Autoimmune Diseases:** Dysregulation of IFNK has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** IFNK has been shown to have anti-tumor effects, and its dysregulation has been linked to cancer progression. 4. **Infectious Diseases:** IFNK is involved in the regulation of immune responses against bacterial and fungal infections, such as tuberculosis and aspergillosis. In conclusion, IFNK is a critical cytokine that plays a central role in the regulation of immune responses against viral, bacterial, and fungal infections. Its dysregulation has been implicated in various diseases, including autoimmune and cancer diseases. Further research is needed to fully elucidate the functions and pathways of IFNK and to explore its potential therapeutic applications.

Genular Protein ID: 2237702169

Symbol: IFNK_HUMAN

Name: Interferon kappa

UniProtKB Accession Codes:

Q9P0W0 Q5T166

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11514542

Title: Interferon-kappa, a novel type I interferon expressed in human keratinocytes.

PubMed ID: 11514542

DOI: 10.1074/jbc.m102502200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12391192

Title: Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system.

PubMed ID: 12391192

DOI: 10.4049/jimmunol.169.9.4822

Sequence Information:

  • Length: 207
  • Mass: 25218
  • Checksum: 49CF4CB5785F0E21
  • Sequence:
    • MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL 
RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ 
QAEYLNQCLE EDKNENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD 
CAWEIVRVEI RRCLYYFYKF TALFRRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.