Details for: RNASE3

Gene ID: 6037

Symbol: RNASE3

Ensembl ID: ENSG00000169397

Description: ribonuclease A family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 36.5794
    Cell Significance Index: 723.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 34.5060
    Cell Significance Index: 720.1700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 30.4878
    Cell Significance Index: 456.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 29.2075
    Cell Significance Index: 930.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 25.7265
    Cell Significance Index: 901.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 22.1925
    Cell Significance Index: 451.5700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 12.1508
    Cell Significance Index: -1.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.2543
    Cell Significance Index: -1.8400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.2860
    Cell Significance Index: 21.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.5832
    Cell Significance Index: 69.1000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.3952
    Cell Significance Index: 15.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.6755
    Cell Significance Index: 20.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.5086
    Cell Significance Index: -1.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.4815
    Cell Significance Index: -1.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0835
    Cell Significance Index: 1.4400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0705
    Cell Significance Index: 0.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0468
    Cell Significance Index: 2.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0082
    Cell Significance Index: 0.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0065
    Cell Significance Index: 0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0055
    Cell Significance Index: 0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0123
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0129
    Cell Significance Index: -0.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0240
    Cell Significance Index: -1.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0257
    Cell Significance Index: -0.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0298
    Cell Significance Index: -1.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0301
    Cell Significance Index: -1.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0305
    Cell Significance Index: -1.6000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0310
    Cell Significance Index: -0.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0320
    Cell Significance Index: -0.7800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0368
    Cell Significance Index: -0.4400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0375
    Cell Significance Index: -0.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0441
    Cell Significance Index: -0.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0449
    Cell Significance Index: -0.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0462
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0463
    Cell Significance Index: -0.7500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0469
    Cell Significance Index: -0.4700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0500
    Cell Significance Index: -0.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0509
    Cell Significance Index: -1.0800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0510
    Cell Significance Index: -0.6200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0515
    Cell Significance Index: -0.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0518
    Cell Significance Index: -0.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0525
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0547
    Cell Significance Index: -1.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0589
    Cell Significance Index: -1.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0593
    Cell Significance Index: -1.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0626
    Cell Significance Index: -1.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0629
    Cell Significance Index: -0.7500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0643
    Cell Significance Index: -0.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0659
    Cell Significance Index: -1.1400
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0708
    Cell Significance Index: -0.7000
  • Cell Name: phagocyte (CL0000234)
    Fold Change: -0.0719
    Cell Significance Index: -0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0787
    Cell Significance Index: -2.1100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0796
    Cell Significance Index: -0.8900
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0800
    Cell Significance Index: -0.6100
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0818
    Cell Significance Index: -0.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0845
    Cell Significance Index: -2.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0855
    Cell Significance Index: -2.0500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0903
    Cell Significance Index: -0.9400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0918
    Cell Significance Index: -0.8300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0923
    Cell Significance Index: -1.1700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0925
    Cell Significance Index: -1.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0961
    Cell Significance Index: -1.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0970
    Cell Significance Index: -0.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0975
    Cell Significance Index: -1.6400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0983
    Cell Significance Index: -1.6800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0987
    Cell Significance Index: -1.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1006
    Cell Significance Index: -1.3200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1014
    Cell Significance Index: -1.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1029
    Cell Significance Index: -1.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1055
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1068
    Cell Significance Index: -1.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1075
    Cell Significance Index: -1.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1091
    Cell Significance Index: -1.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1121
    Cell Significance Index: -1.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1123
    Cell Significance Index: -1.8800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1146
    Cell Significance Index: -1.1700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.1151
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1159
    Cell Significance Index: -1.6600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1173
    Cell Significance Index: -1.3500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1189
    Cell Significance Index: -1.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1211
    Cell Significance Index: -1.5800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1216
    Cell Significance Index: -1.6400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1224
    Cell Significance Index: -1.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1230
    Cell Significance Index: -1.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1233
    Cell Significance Index: -1.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1298
    Cell Significance Index: -1.6100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1303
    Cell Significance Index: -1.5500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1310
    Cell Significance Index: -1.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNASE3 is a member of the ribonuclease A family, which is characterized by its ability to cleave RNA molecules into smaller fragments. The enzyme is known to be involved in various cellular processes, including the regulation of RNA stability, the degradation of viral RNA, and the suppression of bacterial gene expression. In the context of the immune system, RNASE3 has been shown to play a crucial role in the defense against bacterial infections, particularly those caused by gram-negative bacteria. **Pathways and Functions** RNASE3 is involved in several key pathways and functions that are critical to the immune response: 1. **Antibacterial humoral response**: RNASE3 is induced in response to bacterial infections and plays a crucial role in the degradation of bacterial RNA, thereby inhibiting bacterial growth and survival. 2. **Antimicrobial peptides**: RNASE3 is involved in the production and regulation of antimicrobial peptides, which are essential for the defense against bacterial and fungal infections. 3. **Neutrophil degranulation**: RNASE3 is released from neutrophils during the degranulation process, where it plays a crucial role in the degradation of bacterial RNA and the suppression of bacterial gene expression. 4. **Endonuclease activity**: RNASE3 has endonuclease activity, which allows it to cleave RNA molecules into smaller fragments, thereby regulating RNA stability and degradation. 5. **Immune system regulation**: RNASE3 is involved in the regulation of various immune responses, including the induction of bacterial agglutination, the production of cytokines, and the activation of immune cells. **Clinical Significance** The dysregulation of RNASE3 has been implicated in various diseases, including: 1. **Infectious diseases**: RNASE3 deficiency has been associated with increased susceptibility to bacterial infections, particularly those caused by gram-negative bacteria. 2. **Autoimmune diseases**: RNASE3 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a role in the regulation of immune responses. 3. **Cancer**: RNASE3 has been shown to have anti-tumor properties, and its dysregulation has been implicated in various types of cancer. In conclusion, RNASE3 is a critical gene involved in the immune system, particularly in the defense against bacterial infections. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in the regulation of immune responses.

Genular Protein ID: 739921932

Symbol: ECP_HUMAN

Name: Eosinophil cationic protein

UniProtKB Accession Codes:

P12724 Q4VBC1 Q8WTP7 Q8WZ62 Q9GZN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 19 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2473157

Title: Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity.

PubMed ID: 2473157

DOI: 10.1084/jem.170.1.163

PubMed ID: 2387583

Title: Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.

PubMed ID: 2387583

DOI: 10.1016/0888-7543(90)90197-3

PubMed ID: 2745977

Title: Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.

PubMed ID: 2745977

PubMed ID: 11102386

Title: Sequence variation at two eosinophil-associated ribonuclease loci in humans.

PubMed ID: 11102386

DOI: 10.1093/genetics/156.4.1949

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3458170

Title: Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

PubMed ID: 3458170

DOI: 10.1073/pnas.83.10.3146

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 18694936

Title: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.

PubMed ID: 18694936

DOI: 10.1074/jbc.m801196200

PubMed ID: 19450231

Title: Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment.

PubMed ID: 19450231

DOI: 10.1042/bj20082330

PubMed ID: 20690710

Title: Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region.

PubMed ID: 20690710

DOI: 10.1021/bm100334u

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10606511

Title: Crystal structure of eosinophil cationic protein at 2.4 A resolution.

PubMed ID: 10606511

DOI: 10.1021/bi9919145

PubMed ID: 10903870

Title: Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution.

PubMed ID: 10903870

DOI: 10.1006/jmbi.2000.3939

PubMed ID: 12356310

Title: The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site.

PubMed ID: 12356310

DOI: 10.1021/bi0264521

Sequence Information:

  • Length: 160
  • Mass: 18385
  • Checksum: D7BED24F67B23FA9
  • Sequence:
    • MVPKLFTSQI CLLLLLGLMG VEGSLHARPP QFTRAQWFAI QHISLNPPRC TIAMRAINNY 
RWRCKNQNTF LRTTFANVVN VCGNQSIRCP HNRTLNNCHR SRFRVPLLHC DLINPGAQNI 
SNCTYADRPG RRFYVVACDN RDPRDSPRYP VVPVHLDTTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.