Details for: SERPINA7

Gene ID: 6906

Symbol: SERPINA7

Ensembl ID: ENSG00000123561

Description: serpin family A member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 7.0764
    Cell Significance Index: 119.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7334
    Cell Significance Index: 106.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7838
    Cell Significance Index: 155.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6655
    Cell Significance Index: 30.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6425
    Cell Significance Index: 122.2700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.6013
    Cell Significance Index: 5.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4664
    Cell Significance Index: 46.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4010
    Cell Significance Index: 8.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3050
    Cell Significance Index: 275.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2586
    Cell Significance Index: 42.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2036
    Cell Significance Index: 2.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1433
    Cell Significance Index: 15.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1224
    Cell Significance Index: 8.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0706
    Cell Significance Index: 1.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0599
    Cell Significance Index: 1.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0510
    Cell Significance Index: 0.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0481
    Cell Significance Index: 0.7100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0455
    Cell Significance Index: 0.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0253
    Cell Significance Index: 0.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0239
    Cell Significance Index: 0.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0146
    Cell Significance Index: 0.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0018
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0056
    Cell Significance Index: -1.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0075
    Cell Significance Index: -1.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0166
    Cell Significance Index: -0.8600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0194
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0196
    Cell Significance Index: -2.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0214
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0215
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0217
    Cell Significance Index: -0.6900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0220
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0229
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0258
    Cell Significance Index: -0.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0264
    Cell Significance Index: -0.3500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0273
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0287
    Cell Significance Index: -0.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0326
    Cell Significance Index: -0.3800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0337
    Cell Significance Index: -0.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0360
    Cell Significance Index: -26.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0368
    Cell Significance Index: -1.1800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0370
    Cell Significance Index: -0.3900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0376
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0434
    Cell Significance Index: -0.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0450
    Cell Significance Index: -0.9400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0457
    Cell Significance Index: -0.4600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0462
    Cell Significance Index: -0.2900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0469
    Cell Significance Index: -0.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0475
    Cell Significance Index: -1.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0483
    Cell Significance Index: -0.9500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0487
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0552
    Cell Significance Index: -1.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0599
    Cell Significance Index: -10.8000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0609
    Cell Significance Index: -0.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0654
    Cell Significance Index: -1.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0703
    Cell Significance Index: -4.2200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0729
    Cell Significance Index: -1.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0739
    Cell Significance Index: -0.8000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0816
    Cell Significance Index: -0.6900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0818
    Cell Significance Index: -1.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0821
    Cell Significance Index: -1.0800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0838
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0844
    Cell Significance Index: -10.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0866
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0872
    Cell Significance Index: -0.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0966
    Cell Significance Index: -1.0000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1066
    Cell Significance Index: -0.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1142
    Cell Significance Index: -4.0000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1208
    Cell Significance Index: -1.2900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1220
    Cell Significance Index: -1.0700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1242
    Cell Significance Index: -1.2300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1261
    Cell Significance Index: -1.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1290
    Cell Significance Index: -13.1700
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1541
    Cell Significance Index: -1.5700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1561
    Cell Significance Index: -1.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1680
    Cell Significance Index: -2.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1759
    Cell Significance Index: -2.6500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1831
    Cell Significance Index: -1.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2121
    Cell Significance Index: -11.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2513
    Cell Significance Index: -4.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2593
    Cell Significance Index: -4.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2702
    Cell Significance Index: -6.8900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2817
    Cell Significance Index: -3.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2837
    Cell Significance Index: -3.8900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2856
    Cell Significance Index: -3.5100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2983
    Cell Significance Index: -3.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3153
    Cell Significance Index: -8.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SERPINA7 exhibits several key characteristics, including: 1. **Serine protease inhibitor**: SERPINA7 acts as a serine-type endopeptidase inhibitor, regulating the activity of enzymes involved in the degradation of proteins. 2. **Thyroid hormone transport**: THBG, the protein encoded by SERPINA7, binds to thyroid hormones, facilitating their transport and regulation in the body. 3. **Wide tissue expression**: SERPINA7 is expressed in various cell types, including oligodendrocyte precursor cells, microglial cells, endothelial cells, T cells, plasma cells, and epithelial cells. 4. **Regulation of immune response**: SERPINA7 may play a role in modulating the immune response, as it is expressed in immune cells such as T cells and plasma cells. **Pathways and Functions** SERPINA7 is involved in several biological pathways, including: 1. **Negative regulation of endopeptidase activity**: SERPINA7 inhibits the activity of serine proteases, which are involved in the degradation of proteins and the regulation of various cellular processes. 2. **Extracellular exosome and extracellular space**: SERPINA7 is involved in the regulation of the extracellular environment, including the transport of thyroid hormones and the modulation of immune responses. 3. **Thyroid hormone transport**: THBG, the protein encoded by SERPINA7, binds to thyroid hormones, facilitating their transport and regulation in the body. 4. **Regulation of thyroid hormone levels**: SERPINA7 may play a role in regulating thyroid hormone levels, which are essential for maintaining normal metabolic and developmental processes. **Clinical Significance** Dysregulation of SERPINA7 has been implicated in various diseases, including: 1. **Hypothyroidism**: Alterations in SERPINA7 expression have been linked to hypothyroidism, a condition characterized by decreased thyroid hormone production. 2. **Thyroid hormone resistance**: SERPINA7 may play a role in thyroid hormone resistance, a condition characterized by impaired thyroid hormone action. 3. **Autoimmune diseases**: SERPINA7 expression in immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer**: Alterations in SERPINA7 expression have been linked to cancer development and progression, particularly in thyroid and breast cancers. In conclusion, SERPINA7 plays a crucial role in regulating thyroid hormone levels, modulating the immune response, and maintaining the balance of various physiological processes. Further research is needed to fully understand the mechanisms by which SERPINA7 influences disease development and progression.

Genular Protein ID: 2941835746

Symbol: THBG_HUMAN

Name: Thyroxine-binding globulin

UniProtKB Accession Codes:

P05543 D3DUX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 32 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3094014

Title: Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases.

PubMed ID: 3094014

DOI: 10.1073/pnas.83.20.7708

PubMed ID: 8268226

Title: The structure of the human thyroxine binding globulin (TBG) gene.

PubMed ID: 8268226

DOI: 10.1016/0167-4781(93)90013-4

PubMed ID: 8232304

Title: Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.

PubMed ID: 8232304

DOI: 10.1210/mend.7.8.8232304

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 414747

Title: Partial amino acid sequence of human thyroxine-binding globulin. Further evidence for a single polypeptide chain.

PubMed ID: 414747

DOI: 10.1016/0006-291x(77)91135-4

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16938877

Title: Structural mechanism for the carriage and release of thyroxine in the blood.

PubMed ID: 16938877

DOI: 10.1073/pnas.0604080103

PubMed ID: 18407078

Title: Molecular basis of inherited thyroxine-binding globulin defects.

PubMed ID: 18407078

DOI: 10.1016/1043-2760(92)90043-z

PubMed ID: 2155256

Title: Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect.

PubMed ID: 2155256

DOI: 10.1210/jcem-70-3-804

PubMed ID: 2501669

Title: A mutation causing reduced biological activity and stability of thyroxine-binding globulin probably as a result of abnormal glycosylation of the molecule.

PubMed ID: 2501669

DOI: 10.1210/mend-3-3-575

PubMed ID: 1294376

Title: Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family.

PubMed ID: 1294376

DOI: 10.1507/endocrj1954.39.577

PubMed ID: 1906047

Title: Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency.

PubMed ID: 1906047

DOI: 10.1007/bf00204164

PubMed ID: 1901689

Title: Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions.

PubMed ID: 1901689

PubMed ID: 1515456

Title: Sequencing of the variant thyroxine-binding globulin (TBG)-San Diego reveals two nucleotide substitutions.

PubMed ID: 1515456

DOI: 10.1016/0925-4439(92)90105-v

PubMed ID: 2495303

Title: Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.

PubMed ID: 2495303

DOI: 10.1172/jci114021

PubMed ID: 2115061

Title: Molecular basis for the properties of the thyroxine-binding globulin-slow variant in American blacks.

PubMed ID: 2115061

DOI: 10.1007/bf03349576

Sequence Information:

  • Length: 415
  • Mass: 46325
  • Checksum: 8B24EF8C7CEF8F0A
  • Sequence:
    • MSPFLYLVLL VLGLHATIHC ASPEGKVTAC HSSQPNATLY KMSSINADFA FNLYRRFTVE 
TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL TDTPMVEIQH GFQHLICSLN 
FPKKELELQI GNALFIGKHL KPLAKFLNDV KTLYETEVFS TDFSNISAAK QEINSHVEMQ 
TKGKVVGLIQ DLKPNTIMVL VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ 
MEQYYHLVDM ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW 
VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA HKAVLHIGEK 
GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST RSILFLGKVV NPTEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.