Details for: TECTB

Gene ID: 6975

Symbol: TECTB

Ensembl ID: ENSG00000119913

Description: tectorin beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.9960
    Cell Significance Index: 34.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6897
    Cell Significance Index: 40.9300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.1789
    Cell Significance Index: 23.0500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1675
    Cell Significance Index: 16.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4597
    Cell Significance Index: 6.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1992
    Cell Significance Index: 2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1945
    Cell Significance Index: 2.7900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1705
    Cell Significance Index: 0.9000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1140
    Cell Significance Index: 1.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1081
    Cell Significance Index: 1.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0735
    Cell Significance Index: 0.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0398
    Cell Significance Index: 0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0369
    Cell Significance Index: 1.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0321
    Cell Significance Index: 0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0296
    Cell Significance Index: 5.8800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0224
    Cell Significance Index: 0.3100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0183
    Cell Significance Index: 0.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0180
    Cell Significance Index: 0.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0125
    Cell Significance Index: 0.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0058
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0015
    Cell Significance Index: -0.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0022
    Cell Significance Index: -0.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0036
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0041
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0041
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0044
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0045
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0067
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0092
    Cell Significance Index: -0.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0124
    Cell Significance Index: -0.5600
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0132
    Cell Significance Index: -0.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0154
    Cell Significance Index: -0.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0157
    Cell Significance Index: -0.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0169
    Cell Significance Index: -1.0400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0178
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0185
    Cell Significance Index: -1.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0201
    Cell Significance Index: -0.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0209
    Cell Significance Index: -0.9800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0223
    Cell Significance Index: -0.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0226
    Cell Significance Index: -0.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0238
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0242
    Cell Significance Index: -0.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0249
    Cell Significance Index: -0.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0256
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0284
    Cell Significance Index: -0.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0287
    Cell Significance Index: -1.0100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0289
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0297
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0325
    Cell Significance Index: -0.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0326
    Cell Significance Index: -1.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0373
    Cell Significance Index: -0.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0378
    Cell Significance Index: -0.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0380
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0388
    Cell Significance Index: -0.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0389
    Cell Significance Index: -0.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0393
    Cell Significance Index: -0.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0396
    Cell Significance Index: -0.8400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0401
    Cell Significance Index: -0.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0405
    Cell Significance Index: -0.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0420
    Cell Significance Index: -1.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0434
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0437
    Cell Significance Index: -0.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0437
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0454
    Cell Significance Index: -0.2800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0460
    Cell Significance Index: -0.6200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0471
    Cell Significance Index: -0.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0488
    Cell Significance Index: -1.1700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0490
    Cell Significance Index: -0.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0496
    Cell Significance Index: -0.5400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0522
    Cell Significance Index: -0.6600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0524
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0536
    Cell Significance Index: -0.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0549
    Cell Significance Index: -0.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0574
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0578
    Cell Significance Index: -0.7300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0580
    Cell Significance Index: -0.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0593
    Cell Significance Index: -0.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0609
    Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TECTB is a GPI-anchored protein, characterized by its attachment to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. This attachment allows TECTB to interact with other cellular components and extracellular matrix proteins, influencing cellular behavior and function. The protein is also known to undergo post-translational modifications, including synthesis of GPI-anchored proteins, which further regulates its activity and localization. TECTB exhibits a broad tissue distribution, with significant expression in erythrocytes, blood vessel endothelial cells, plasma cells, and hematopoietic stem cells, among others. **Pathways and Functions:** TECTB is involved in various cellular processes, including: 1. **Cell adhesion and migration**: TECTB interacts with other cellular components and extracellular matrix proteins, influencing cellular adhesion, migration, and wound healing. 2. **Erythrocyte membrane integrity**: TECTB is expressed in erythrocytes and plays a crucial role in maintaining the integrity of the erythrocyte membrane, which is essential for the proper functioning of red blood cells. 3. **Blood vessel endothelium maintenance**: TECTB is involved in the structural organization and maintenance of the blood vessel endothelium, which is critical for maintaining vascular homeostasis and preventing vascular diseases. 4. **Hematopoietic cell development and function**: TECTB is expressed in hematopoietic stem cells, plasma cells, and megakaryocytes, highlighting its importance in the development and function of the hematopoietic system. **Clinical Significance:** Dysregulation of TECTB has been implicated in various diseases, including: 1. **Cardiovascular disease**: Abnormalities in TECTB expression have been linked to cardiovascular disease, including atherosclerosis and hypertension. 2. **Hematological disorders**: TECTB dysregulation has been implicated in hematological disorders, including sickle cell disease and anemia. 3. **Neurological disorders**: TECTB has been implicated in neurological disorders, including Alzheimer's disease and schizophrenia. In summary, TECTB is a critical protein that plays a key role in maintaining cellular integrity and function in various tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TECTB regulation and its potential therapeutic applications.

Genular Protein ID: 50636811

Symbol: TECTB_HUMAN

Name: Beta-tectorin

UniProtKB Accession Codes:

Q96PL2 Q5VW53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 329
  • Mass: 36956
  • Checksum: 0B4D379624F488D0
  • Sequence:
    • MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV HQLALGGLCY 
NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH IVSNDTTVIV KNQPVNYSFS 
CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT FESQLSLNFY TNAKFSIKKE APFVLEASEI 
GSDLFAGVEA KGLSIRFKVV LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH 
RATFQFNAFR FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS 
LRSRGFSSLY SFSDVLHHLI MMLGICAVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.