Details for: TECTB

Gene ID: 6975

Symbol: TECTB

Ensembl ID: ENSG00000119913

Description: tectorin beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.77
    Marker Score: 2642
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3173
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2219
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.57
    Marker Score: 892
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.41
    Marker Score: 1940
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.23
    Marker Score: 646
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7499
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.08
    Marker Score: 567
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.77
    Marker Score: 323
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1157
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10493
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 199.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1161
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.53
    Marker Score: 310
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 336
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.5
    Marker Score: 1035
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 917
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.45
    Marker Score: 260
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 287
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.36
    Marker Score: 363
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 190.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.31
    Marker Score: 297
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 263
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 173
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 332
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 126.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.09
    Marker Score: 72
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 207
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.06
    Marker Score: 790
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.05
    Marker Score: 25.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 255
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.03
    Marker Score: 79
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 69
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.03
    Marker Score: 117
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 167
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 104
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 60
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.02
    Marker Score: 61
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 27

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Other Information

**Key Characteristics:** TECTB is a GPI-anchored protein, characterized by its attachment to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. This attachment allows TECTB to interact with other cellular components and extracellular matrix proteins, influencing cellular behavior and function. The protein is also known to undergo post-translational modifications, including synthesis of GPI-anchored proteins, which further regulates its activity and localization. TECTB exhibits a broad tissue distribution, with significant expression in erythrocytes, blood vessel endothelial cells, plasma cells, and hematopoietic stem cells, among others. **Pathways and Functions:** TECTB is involved in various cellular processes, including: 1. **Cell adhesion and migration**: TECTB interacts with other cellular components and extracellular matrix proteins, influencing cellular adhesion, migration, and wound healing. 2. **Erythrocyte membrane integrity**: TECTB is expressed in erythrocytes and plays a crucial role in maintaining the integrity of the erythrocyte membrane, which is essential for the proper functioning of red blood cells. 3. **Blood vessel endothelium maintenance**: TECTB is involved in the structural organization and maintenance of the blood vessel endothelium, which is critical for maintaining vascular homeostasis and preventing vascular diseases. 4. **Hematopoietic cell development and function**: TECTB is expressed in hematopoietic stem cells, plasma cells, and megakaryocytes, highlighting its importance in the development and function of the hematopoietic system. **Clinical Significance:** Dysregulation of TECTB has been implicated in various diseases, including: 1. **Cardiovascular disease**: Abnormalities in TECTB expression have been linked to cardiovascular disease, including atherosclerosis and hypertension. 2. **Hematological disorders**: TECTB dysregulation has been implicated in hematological disorders, including sickle cell disease and anemia. 3. **Neurological disorders**: TECTB has been implicated in neurological disorders, including Alzheimer's disease and schizophrenia. In summary, TECTB is a critical protein that plays a key role in maintaining cellular integrity and function in various tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TECTB regulation and its potential therapeutic applications.

Genular Protein ID: 50636811

Symbol: TECTB_HUMAN

Name: Beta-tectorin

UniProtKB Accession Codes:

Q96PL2 Q5VW53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 329
  • Mass: 36956
  • Checksum: 0B4D379624F488D0
  • Sequence:
    • MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV HQLALGGLCY 
NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH IVSNDTTVIV KNQPVNYSFS 
CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT FESQLSLNFY TNAKFSIKKE APFVLEASEI 
GSDLFAGVEA KGLSIRFKVV LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH 
RATFQFNAFR FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS 
LRSRGFSSLY SFSDVLHHLI MMLGICAVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.