Details for: TFF1

Gene ID: 7031

Symbol: TFF1

Ensembl ID: ENSG00000160182

Description: trefoil factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.9838
    Cell Significance Index: -26.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 36.0617
    Cell Significance Index: 899.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2735
    Cell Significance Index: -30.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.0766
    Cell Significance Index: 49.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.4297
    Cell Significance Index: 330.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.6587
    Cell Significance Index: 79.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9211
    Cell Significance Index: 43.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 2.0678
    Cell Significance Index: 236.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6255
    Cell Significance Index: 73.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.5898
    Cell Significance Index: 17.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2696
    Cell Significance Index: 65.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1509
    Cell Significance Index: 113.8500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.0917
    Cell Significance Index: 7.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.9219
    Cell Significance Index: 9.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8915
    Cell Significance Index: 486.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8575
    Cell Significance Index: 30.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5974
    Cell Significance Index: 97.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5537
    Cell Significance Index: 60.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5439
    Cell Significance Index: 103.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4073
    Cell Significance Index: 24.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2914
    Cell Significance Index: 20.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1402
    Cell Significance Index: 4.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0787
    Cell Significance Index: 71.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0562
    Cell Significance Index: 10.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0315
    Cell Significance Index: 19.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0135
    Cell Significance Index: -1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0158
    Cell Significance Index: -29.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0325
    Cell Significance Index: -24.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0423
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0520
    Cell Significance Index: -29.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1015
    Cell Significance Index: -11.8300
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1118
    Cell Significance Index: -0.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1351
    Cell Significance Index: -26.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1373
    Cell Significance Index: -28.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1387
    Cell Significance Index: -62.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1710
    Cell Significance Index: -29.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1754
    Cell Significance Index: -35.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1774
    Cell Significance Index: -20.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2104
    Cell Significance Index: -6.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2263
    Cell Significance Index: -31.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2535
    Cell Significance Index: -25.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2865
    Cell Significance Index: -29.8300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3098
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3234
    Cell Significance Index: -5.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3451
    Cell Significance Index: -7.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3719
    Cell Significance Index: -22.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4066
    Cell Significance Index: -19.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4927
    Cell Significance Index: -10.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5539
    Cell Significance Index: -13.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6003
    Cell Significance Index: -33.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6549
    Cell Significance Index: -6.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8547
    Cell Significance Index: -29.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.9058
    Cell Significance Index: -11.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9303
    Cell Significance Index: -34.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9565
    Cell Significance Index: -25.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9670
    Cell Significance Index: -27.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9817
    Cell Significance Index: -32.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0265
    Cell Significance Index: -27.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0430
    Cell Significance Index: -26.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0450
    Cell Significance Index: -30.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0701
    Cell Significance Index: -18.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1010
    Cell Significance Index: -29.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.1011
    Cell Significance Index: -18.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.1129
    Cell Significance Index: -11.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1658
    Cell Significance Index: -37.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2146
    Cell Significance Index: -26.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.2552
    Cell Significance Index: -20.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2881
    Cell Significance Index: -32.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.3241
    Cell Significance Index: -57.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4509
    Cell Significance Index: -67.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.4620
    Cell Significance Index: -22.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4652
    Cell Significance Index: -27.0800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -1.4818
    Cell Significance Index: -13.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.4876
    Cell Significance Index: -32.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.4931
    Cell Significance Index: -22.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.5205
    Cell Significance Index: -38.7400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -1.5367
    Cell Significance Index: -7.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.5573
    Cell Significance Index: -31.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.5817
    Cell Significance Index: -31.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.6335
    Cell Significance Index: -32.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.6778
    Cell Significance Index: -35.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6999
    Cell Significance Index: -28.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.7845
    Cell Significance Index: -34.8900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -1.7893
    Cell Significance Index: -18.2500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -1.8004
    Cell Significance Index: -21.7600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8041
    Cell Significance Index: -31.1000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -1.8227
    Cell Significance Index: -25.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.8242
    Cell Significance Index: -25.9200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.8502
    Cell Significance Index: -19.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.8645
    Cell Significance Index: -27.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.9086
    Cell Significance Index: -33.0000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.9580
    Cell Significance Index: -27.5000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -1.9970
    Cell Significance Index: -20.6000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.0010
    Cell Significance Index: -34.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.0298
    Cell Significance Index: -27.8400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -2.1001
    Cell Significance Index: -30.6100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -2.1034
    Cell Significance Index: -26.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -2.1764
    Cell Significance Index: -27.5000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -2.1785
    Cell Significance Index: -27.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFF1 is a member of the trefoil factor family, which consists of three proteins (TFF1, TFF2, and TFF3). TFF1 is a 36-kDa protein that belongs to the cysteine-rich protein family. It is secreted by epithelial cells and has been shown to play a role in maintaining the integrity of the epithelial barrier, promoting cell differentiation, and regulating cell proliferation. TFF1 is also involved in the regulation of immune responses, particularly in the context of the gastrointestinal tract. **Pathways and Functions:** TFF1 is involved in various signaling pathways, including: 1. **Growth factor activity:** TFF1 acts as a growth factor, promoting the proliferation and differentiation of epithelial cells. 2. **Cell differentiation:** TFF1 regulates the differentiation of epithelial cells, particularly in the gastrointestinal tract. 3. **Maintenance of gastrointestinal epithelium:** TFF1 plays a crucial role in maintaining the integrity of the gastrointestinal epithelium, particularly in the context of inflammation and injury. 4. **Negative regulation of cell population proliferation:** TFF1 acts as a negative regulator of cell population proliferation, preventing excessive cell growth and maintaining tissue homeostasis. 5. **Signal transduction:** TFF1 interacts with various signaling molecules, including nuclear receptors and growth factor receptors, to regulate cellular responses. **Clinical Significance:** TFF1 has been implicated in various diseases, including: 1. **Gastrointestinal disorders:** TFF1 has been shown to play a role in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD) and peptic ulcers. 2. **Cancer:** TFF1 has been implicated in the development and progression of various cancers, including colorectal, breast, and prostate cancer. 3. **Immune disorders:** TFF1 has been shown to play a role in the regulation of immune responses, particularly in the context of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders:** TFF1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TFF1 is a multifunctional protein that plays a crucial role in maintaining the integrity and function of the gastrointestinal epithelium. Its involvement in various signaling pathways and its expression in immune cells and progenitor cells of the mammary luminal epithelium make it an important regulator of immune responses and tissue homeostasis. Further research is needed to fully elucidate the role of TFF1 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 1483583879

Symbol: TFF1_HUMAN

Name: Trefoil factor 1

UniProtKB Accession Codes:

P04155

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6324130

Title: Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7.

PubMed ID: 6324130

DOI: 10.1093/nar/12.6.2861

PubMed ID: 3838275

Title: Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells.

PubMed ID: 3838275

DOI: 10.1089/dna.1985.4.11

PubMed ID: 3822834

Title: Structure of the human oestrogen-responsive gene pS2.

PubMed ID: 3822834

DOI: 10.1093/nar/15.4.1401

PubMed ID: 2311759

Title: Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma.

PubMed ID: 2311759

DOI: 10.1016/0014-5793(90)80572-z

PubMed ID: 2185238

Title: Complete primary structure of the human estrogen-responsive gene (pS2) product.

PubMed ID: 2185238

DOI: 10.1093/oxfordjournals.jbchem.a123014

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3146413

Title: Primary structure of human protein pS2.

PubMed ID: 3146413

PubMed ID: 15924415

Title: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C.

PubMed ID: 15924415

DOI: 10.1021/bi047287n

PubMed ID: 16308573

Title: Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor.

PubMed ID: 16308573

DOI: 10.1172/jci25342

PubMed ID: 3261981

Title: Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product.

PubMed ID: 3261981

DOI: 10.1016/s0006-291x(88)81094-5

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 3041593

Title: Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.

PubMed ID: 3041593

DOI: 10.1126/science.3041593

PubMed ID: 16718800

Title: Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.

PubMed ID: 16718800

DOI: 10.3748/wjg.v12.i19.3119

PubMed ID: 17143957

Title: Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues.

PubMed ID: 17143957

DOI: 10.3748/wjg.v12.i45.7361

PubMed ID: 17242463

Title: Tissue localization of human trefoil factors 1, 2, and 3.

PubMed ID: 17242463

DOI: 10.1369/jhc.6a7100.2007

PubMed ID: 8521850

Title: NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure.

PubMed ID: 8521850

DOI: 10.1111/j.1432-1033.1995.847_3.x

PubMed ID: 9096235

Title: High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein.

PubMed ID: 9096235

DOI: 10.1006/jmbi.1997.0896

PubMed ID: 10982763

Title: Somatic mutations of the trefoil factor family 1 gene in gastric cancer.

PubMed ID: 10982763

DOI: 10.1053/gast.2000.16483

PubMed ID: 16697734

Title: Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.

PubMed ID: 16697734

DOI: 10.1053/j.gastro.2006.01.040

Sequence Information:

  • Length: 84
  • Mass: 9150
  • Checksum: 65198523BAD6EBC7
  • Sequence:
    • MATMENKVIC ALVLVSMLAL GTLAEAQTET CTVAPRERQN CGFPGVTPSQ CANKGCCFDD 
TVRGVPWCFY PNTIDVPPEE ECEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.