Details for: TFF1

Gene ID: 7031

Symbol: TFF1

Ensembl ID: ENSG00000160182

Description: trefoil factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.93
    Marker Score: 31484
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.66
    Marker Score: 1261
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.31
    Marker Score: 7501
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.72
    Marker Score: 2315
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.5
    Marker Score: 2394
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.27
    Marker Score: 1289
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.23
    Marker Score: 933
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.97
    Marker Score: 735
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.86
    Marker Score: 958
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.83
    Marker Score: 7046.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.81
    Marker Score: 644
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.81
    Marker Score: 1311
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.21
    Marker Score: 5801
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.18
    Marker Score: 609
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.14
    Marker Score: 491
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.06
    Marker Score: 551
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.03
    Marker Score: 1036
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.01
    Marker Score: 321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.95
    Marker Score: 32875
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5211
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 494.5
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.75
    Marker Score: 208
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.71
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2966
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.7
    Marker Score: 471
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.67
    Marker Score: 201
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.65
    Marker Score: 2052
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.63
    Marker Score: 275
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 364
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.63
    Marker Score: 365
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.61
    Marker Score: 302
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.59
    Marker Score: 1075
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.57
    Marker Score: 1343
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.53
    Marker Score: 152
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.53
    Marker Score: 811
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 497
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.51
    Marker Score: 140
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.49
    Marker Score: 549
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 470
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.46
    Marker Score: 310
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.45
    Marker Score: 659
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 204
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.43
    Marker Score: 3696
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.43
    Marker Score: 310
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.43
    Marker Score: 424
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.42
    Marker Score: 231
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.41
    Marker Score: 5474
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4
    Marker Score: 312
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.39
    Marker Score: 113
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 158.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.36
    Marker Score: 638
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.36
    Marker Score: 72
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 570
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.35
    Marker Score: 314
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.34
    Marker Score: 966
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.34
    Marker Score: 579
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.34
    Marker Score: 304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 340
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.32
    Marker Score: 309
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.3
    Marker Score: 224
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.29
    Marker Score: 1944.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.29
    Marker Score: 313
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 259
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 422
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.26
    Marker Score: 51
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.26
    Marker Score: 282
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.26
    Marker Score: 179
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.25
    Marker Score: 57
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 269
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.24
    Marker Score: 54
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 234

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Other Information

**Key Characteristics:** TFF1 is a member of the trefoil factor family, which consists of three proteins (TFF1, TFF2, and TFF3). TFF1 is a 36-kDa protein that belongs to the cysteine-rich protein family. It is secreted by epithelial cells and has been shown to play a role in maintaining the integrity of the epithelial barrier, promoting cell differentiation, and regulating cell proliferation. TFF1 is also involved in the regulation of immune responses, particularly in the context of the gastrointestinal tract. **Pathways and Functions:** TFF1 is involved in various signaling pathways, including: 1. **Growth factor activity:** TFF1 acts as a growth factor, promoting the proliferation and differentiation of epithelial cells. 2. **Cell differentiation:** TFF1 regulates the differentiation of epithelial cells, particularly in the gastrointestinal tract. 3. **Maintenance of gastrointestinal epithelium:** TFF1 plays a crucial role in maintaining the integrity of the gastrointestinal epithelium, particularly in the context of inflammation and injury. 4. **Negative regulation of cell population proliferation:** TFF1 acts as a negative regulator of cell population proliferation, preventing excessive cell growth and maintaining tissue homeostasis. 5. **Signal transduction:** TFF1 interacts with various signaling molecules, including nuclear receptors and growth factor receptors, to regulate cellular responses. **Clinical Significance:** TFF1 has been implicated in various diseases, including: 1. **Gastrointestinal disorders:** TFF1 has been shown to play a role in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD) and peptic ulcers. 2. **Cancer:** TFF1 has been implicated in the development and progression of various cancers, including colorectal, breast, and prostate cancer. 3. **Immune disorders:** TFF1 has been shown to play a role in the regulation of immune responses, particularly in the context of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders:** TFF1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TFF1 is a multifunctional protein that plays a crucial role in maintaining the integrity and function of the gastrointestinal epithelium. Its involvement in various signaling pathways and its expression in immune cells and progenitor cells of the mammary luminal epithelium make it an important regulator of immune responses and tissue homeostasis. Further research is needed to fully elucidate the role of TFF1 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 1483583879

Symbol: TFF1_HUMAN

Name: Trefoil factor 1

UniProtKB Accession Codes:

P04155

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6324130

Title: Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7.

PubMed ID: 6324130

DOI: 10.1093/nar/12.6.2861

PubMed ID: 3838275

Title: Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells.

PubMed ID: 3838275

DOI: 10.1089/dna.1985.4.11

PubMed ID: 3822834

Title: Structure of the human oestrogen-responsive gene pS2.

PubMed ID: 3822834

DOI: 10.1093/nar/15.4.1401

PubMed ID: 2311759

Title: Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma.

PubMed ID: 2311759

DOI: 10.1016/0014-5793(90)80572-z

PubMed ID: 2185238

Title: Complete primary structure of the human estrogen-responsive gene (pS2) product.

PubMed ID: 2185238

DOI: 10.1093/oxfordjournals.jbchem.a123014

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3146413

Title: Primary structure of human protein pS2.

PubMed ID: 3146413

PubMed ID: 15924415

Title: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C.

PubMed ID: 15924415

DOI: 10.1021/bi047287n

PubMed ID: 16308573

Title: Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor.

PubMed ID: 16308573

DOI: 10.1172/jci25342

PubMed ID: 3261981

Title: Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product.

PubMed ID: 3261981

DOI: 10.1016/s0006-291x(88)81094-5

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 3041593

Title: Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.

PubMed ID: 3041593

DOI: 10.1126/science.3041593

PubMed ID: 16718800

Title: Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.

PubMed ID: 16718800

DOI: 10.3748/wjg.v12.i19.3119

PubMed ID: 17143957

Title: Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues.

PubMed ID: 17143957

DOI: 10.3748/wjg.v12.i45.7361

PubMed ID: 17242463

Title: Tissue localization of human trefoil factors 1, 2, and 3.

PubMed ID: 17242463

DOI: 10.1369/jhc.6a7100.2007

PubMed ID: 8521850

Title: NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure.

PubMed ID: 8521850

DOI: 10.1111/j.1432-1033.1995.847_3.x

PubMed ID: 9096235

Title: High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein.

PubMed ID: 9096235

DOI: 10.1006/jmbi.1997.0896

PubMed ID: 10982763

Title: Somatic mutations of the trefoil factor family 1 gene in gastric cancer.

PubMed ID: 10982763

DOI: 10.1053/gast.2000.16483

PubMed ID: 16697734

Title: Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.

PubMed ID: 16697734

DOI: 10.1053/j.gastro.2006.01.040

Sequence Information:

  • Length: 84
  • Mass: 9150
  • Checksum: 65198523BAD6EBC7
  • Sequence:
    • MATMENKVIC ALVLVSMLAL GTLAEAQTET CTVAPRERQN CGFPGVTPSQ CANKGCCFDD 
TVRGVPWCFY PNTIDVPPEE ECEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.