Details for: UGT2B10

Gene ID: 7365

Symbol: UGT2B10

Ensembl ID: ENSG00000109181

Description: UDP glucuronosyltransferase family 2 member B10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 5.11
    Marker Score: 7055.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.97
    Marker Score: 2089
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.88
    Marker Score: 2204
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.13
    Marker Score: 891.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.12
    Marker Score: 3657
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2172
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.53
    Marker Score: 1014
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.47
    Marker Score: 1071.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1189
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.17
    Marker Score: 650
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4774.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.11
    Marker Score: 419.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7248
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.04
    Marker Score: 711
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 380
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5279
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 826.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8
    Marker Score: 5113.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.71
    Marker Score: 3075
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.71
    Marker Score: 755
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 685
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 533
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.63
    Marker Score: 139
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6
    Marker Score: 3202
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.57
    Marker Score: 180
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5
    Marker Score: 120
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 138.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 385
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.41
    Marker Score: 123
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.41
    Marker Score: 437
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 124.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.39
    Marker Score: 106.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.39
    Marker Score: 139
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.39
    Marker Score: 144
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.36
    Marker Score: 90
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.35
    Marker Score: 130.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.35
    Marker Score: 126
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.34
    Marker Score: 336
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.33
    Marker Score: 251
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.27
    Marker Score: 138
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.26
    Marker Score: 120
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.25
    Marker Score: 70.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 483
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.21
    Marker Score: 108.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 127
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 100.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.18
    Marker Score: 124
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.16
    Marker Score: 135
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.16
    Marker Score: 171
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.15
    Marker Score: 110.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 141
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 99
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 129
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 128
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 81.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 158
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 118
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 226
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 132
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 132
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.06
    Marker Score: 135
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.06
    Marker Score: 85
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 114
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.05
    Marker Score: 149
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.05
    Marker Score: 161
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 285.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 133
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.04
    Marker Score: 133
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.04
    Marker Score: 87
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 124

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Other Information

**Key Characteristics:** 1. **Glucuronidation enzyme**: UGT2B10 is a member of the UDP-glucuronosyltransferase family, which is responsible for the conjugation of glucuronic acid to various substrates, including drugs, hormones, and xenobiotics. 2. **Specific expression**: UGT2B10 is significantly expressed in hematopoietic stem cells, megakaryocytes, and plasma cells, suggesting its importance in immune function and cellular homeostasis. 3. **Multiple metabolic pathways**: UGT2B10 is involved in lipid metabolism, estrogen metabolism, cellular glucuronidation, and other metabolic processes, highlighting its multifaceted role in maintaining cellular homeostasis. 4. **Aspirin metabolism**: UGT2B10 is involved in the metabolism of aspirin, a nonsteroidal anti-inflammatory drug (NSAID), which is a significant aspect of its clinical significance. **Pathways and Functions:** 1. **Glucuronidation**: UGT2B10 catalyzes the conjugation of glucuronic acid to various substrates, including drugs, hormones, and xenobiotics, which facilitates their elimination from the body. 2. **Lipid metabolism**: UGT2B10 is involved in the metabolism of lipids, including cholesterol and phospholipids, which is essential for maintaining cellular homeostasis. 3. **Estrogen metabolism**: UGT2B10 is involved in the metabolism of estrogen, a hormone that plays a crucial role in reproductive and developmental processes. 4. **Cellular glucuronidation**: UGT2B10 is involved in the glucuronidation of various compounds, including drugs, hormones, and xenobiotics, which is essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Aspirin therapy**: UGT2B10 is involved in the metabolism of aspirin, and genetic variations in the UGT2B10 gene can influence the efficacy and toxicity of aspirin therapy. 2. **Cancer therapy**: UGT2B10 is involved in the metabolism of various chemotherapeutic agents, and genetic variations in the UGT2B10 gene can influence the efficacy and toxicity of cancer therapy. 3. **Immune function**: UGT2B10 is expressed in hematopoietic stem cells, megakaryocytes, and plasma cells, suggesting its importance in immune function and cellular homeostasis. 4. **Xenobiotic metabolism**: UGT2B10 is involved in the metabolism of various xenobiotics, including environmental pollutants and pharmaceuticals, which is essential for maintaining cellular homeostasis. In conclusion, the UGT2B10 gene is a crucial player in glucuronidation and metabolic processes, and its dysfunction or genetic variations can have significant implications for human health. Further research is needed to fully understand the role of UGT2B10 in maintaining cellular homeostasis and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 2618198932

Symbol: UDB10_HUMAN

Name: UDP-glucuronosyltransferase 2B10

UniProtKB Accession Codes:

P36537 A8K9M3 B4DPP1 Q14CR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 6 Ensembl 4 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8333863

Title: cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.

PubMed ID: 8333863

DOI: 10.1006/bbrc.1993.1847

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 528
  • Mass: 60774
  • Checksum: 5E6EA3DBC032C2E0
  • Sequence:
    • MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS 
ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND 
IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE 
RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG 
RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND 
LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS 
STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 
NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.