Details for: UGT2B10

Gene ID: 7365

Symbol: UGT2B10

Ensembl ID: ENSG00000109181

Description: UDP glucuronosyltransferase family 2 member B10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 8.0985
    Cell Significance Index: 138.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 6.1443
    Cell Significance Index: 99.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 4.4553
    Cell Significance Index: 57.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.1153
    Cell Significance Index: 43.8800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.6225
    Cell Significance Index: 4.2800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.5322
    Cell Significance Index: 14.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1583
    Cell Significance Index: 37.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0478
    Cell Significance Index: 15.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.8880
    Cell Significance Index: 10.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5217
    Cell Significance Index: 7.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4946
    Cell Significance Index: 10.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4856
    Cell Significance Index: 8.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4528
    Cell Significance Index: 5.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3857
    Cell Significance Index: 5.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2842
    Cell Significance Index: 4.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2407
    Cell Significance Index: 47.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2300
    Cell Significance Index: 13.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2124
    Cell Significance Index: 34.5500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2110
    Cell Significance Index: 1.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1933
    Cell Significance Index: 3.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1688
    Cell Significance Index: 32.1200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1049
    Cell Significance Index: 0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0968
    Cell Significance Index: 1.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0871
    Cell Significance Index: 1.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0711
    Cell Significance Index: 2.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0682
    Cell Significance Index: 1.7000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0464
    Cell Significance Index: 0.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0222
    Cell Significance Index: 2.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0202
    Cell Significance Index: 0.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0084
    Cell Significance Index: 0.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0060
    Cell Significance Index: 0.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0044
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0051
    Cell Significance Index: -0.2100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0100
    Cell Significance Index: -2.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0106
    Cell Significance Index: -0.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0114
    Cell Significance Index: -0.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0119
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0131
    Cell Significance Index: -1.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0161
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0167
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0177
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0206
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0218
    Cell Significance Index: -3.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0225
    Cell Significance Index: -2.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0271
    Cell Significance Index: -1.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0320
    Cell Significance Index: -1.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0328
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0337
    Cell Significance Index: -0.9700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0444
    Cell Significance Index: -1.9300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0484
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0487
    Cell Significance Index: -7.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0510
    Cell Significance Index: -1.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0573
    Cell Significance Index: -2.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0606
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0638
    Cell Significance Index: -1.8200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0705
    Cell Significance Index: -0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0715
    Cell Significance Index: -1.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0893
    Cell Significance Index: -1.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0913
    Cell Significance Index: -2.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0962
    Cell Significance Index: -1.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1051
    Cell Significance Index: -2.2300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1060
    Cell Significance Index: -1.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1101
    Cell Significance Index: -1.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1116
    Cell Significance Index: -2.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1146
    Cell Significance Index: -2.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1183
    Cell Significance Index: -2.9500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1215
    Cell Significance Index: -1.6200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1287
    Cell Significance Index: -1.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1290
    Cell Significance Index: -1.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1312
    Cell Significance Index: -1.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1350
    Cell Significance Index: -1.5500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1376
    Cell Significance Index: -1.6500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1383
    Cell Significance Index: -1.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1415
    Cell Significance Index: -1.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1440
    Cell Significance Index: -1.7500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1444
    Cell Significance Index: -1.8600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1449
    Cell Significance Index: -1.6700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1455
    Cell Significance Index: -1.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1459
    Cell Significance Index: -3.5400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1488
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1490
    Cell Significance Index: -1.8800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1501
    Cell Significance Index: -1.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1537
    Cell Significance Index: -3.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1548
    Cell Significance Index: -1.8200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1608
    Cell Significance Index: -1.3700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1620
    Cell Significance Index: -1.8900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1635
    Cell Significance Index: -1.9900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1653
    Cell Significance Index: -1.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1665
    Cell Significance Index: -3.2600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1723
    Cell Significance Index: -1.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glucuronidation enzyme**: UGT2B10 is a member of the UDP-glucuronosyltransferase family, which is responsible for the conjugation of glucuronic acid to various substrates, including drugs, hormones, and xenobiotics. 2. **Specific expression**: UGT2B10 is significantly expressed in hematopoietic stem cells, megakaryocytes, and plasma cells, suggesting its importance in immune function and cellular homeostasis. 3. **Multiple metabolic pathways**: UGT2B10 is involved in lipid metabolism, estrogen metabolism, cellular glucuronidation, and other metabolic processes, highlighting its multifaceted role in maintaining cellular homeostasis. 4. **Aspirin metabolism**: UGT2B10 is involved in the metabolism of aspirin, a nonsteroidal anti-inflammatory drug (NSAID), which is a significant aspect of its clinical significance. **Pathways and Functions:** 1. **Glucuronidation**: UGT2B10 catalyzes the conjugation of glucuronic acid to various substrates, including drugs, hormones, and xenobiotics, which facilitates their elimination from the body. 2. **Lipid metabolism**: UGT2B10 is involved in the metabolism of lipids, including cholesterol and phospholipids, which is essential for maintaining cellular homeostasis. 3. **Estrogen metabolism**: UGT2B10 is involved in the metabolism of estrogen, a hormone that plays a crucial role in reproductive and developmental processes. 4. **Cellular glucuronidation**: UGT2B10 is involved in the glucuronidation of various compounds, including drugs, hormones, and xenobiotics, which is essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Aspirin therapy**: UGT2B10 is involved in the metabolism of aspirin, and genetic variations in the UGT2B10 gene can influence the efficacy and toxicity of aspirin therapy. 2. **Cancer therapy**: UGT2B10 is involved in the metabolism of various chemotherapeutic agents, and genetic variations in the UGT2B10 gene can influence the efficacy and toxicity of cancer therapy. 3. **Immune function**: UGT2B10 is expressed in hematopoietic stem cells, megakaryocytes, and plasma cells, suggesting its importance in immune function and cellular homeostasis. 4. **Xenobiotic metabolism**: UGT2B10 is involved in the metabolism of various xenobiotics, including environmental pollutants and pharmaceuticals, which is essential for maintaining cellular homeostasis. In conclusion, the UGT2B10 gene is a crucial player in glucuronidation and metabolic processes, and its dysfunction or genetic variations can have significant implications for human health. Further research is needed to fully understand the role of UGT2B10 in maintaining cellular homeostasis and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 2618198932

Symbol: UDB10_HUMAN

Name: UDP-glucuronosyltransferase 2B10

UniProtKB Accession Codes:

P36537 A8K9M3 B4DPP1 Q14CR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 6 Ensembl 4 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8333863

Title: cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.

PubMed ID: 8333863

DOI: 10.1006/bbrc.1993.1847

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 528
  • Mass: 60774
  • Checksum: 5E6EA3DBC032C2E0
  • Sequence:
    • MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS 
ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND 
IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE 
RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG 
RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND 
LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS 
STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 
NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.