Details for: MKRN7P

Gene ID: 7686

Symbol: MKRN7P

Ensembl ID: ENSG00000225849

Description: makorin ring finger protein 7, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2281
    Cell Significance Index: 2.3600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1143
    Cell Significance Index: 1.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1091
    Cell Significance Index: 1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0857
    Cell Significance Index: 9.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0759
    Cell Significance Index: 12.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0225
    Cell Significance Index: 0.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0066
    Cell Significance Index: 0.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0060
    Cell Significance Index: 0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0033
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0075
    Cell Significance Index: -0.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0226
    Cell Significance Index: -0.4500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0426
    Cell Significance Index: -1.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0429
    Cell Significance Index: -0.5200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0477
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0493
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0577
    Cell Significance Index: -2.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0650
    Cell Significance Index: -2.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0669
    Cell Significance Index: -2.1900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0679
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0735
    Cell Significance Index: -1.0100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0738
    Cell Significance Index: -0.8500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0758
    Cell Significance Index: -0.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0777
    Cell Significance Index: -2.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0787
    Cell Significance Index: -1.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0789
    Cell Significance Index: -2.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0806
    Cell Significance Index: -1.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0818
    Cell Significance Index: -2.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0819
    Cell Significance Index: -1.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0828
    Cell Significance Index: -1.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0844
    Cell Significance Index: -1.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0872
    Cell Significance Index: -1.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0886
    Cell Significance Index: -2.2100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0889
    Cell Significance Index: -0.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0963
    Cell Significance Index: -2.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1006
    Cell Significance Index: -2.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1073
    Cell Significance Index: -2.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1103
    Cell Significance Index: -2.1700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1197
    Cell Significance Index: -0.9900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1224
    Cell Significance Index: -1.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1486
    Cell Significance Index: -1.9400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1538
    Cell Significance Index: -1.8300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1548
    Cell Significance Index: -1.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1555
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1578
    Cell Significance Index: -1.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1634
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1683
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1732
    Cell Significance Index: -1.7700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1743
    Cell Significance Index: -2.0900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1768
    Cell Significance Index: -1.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1829
    Cell Significance Index: -2.1800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1849
    Cell Significance Index: -2.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1852
    Cell Significance Index: -2.1200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1900
    Cell Significance Index: -2.3800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1920
    Cell Significance Index: -2.1800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1956
    Cell Significance Index: -2.0500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1971
    Cell Significance Index: -1.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1996
    Cell Significance Index: -2.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2001
    Cell Significance Index: -2.5300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2017
    Cell Significance Index: -2.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2069
    Cell Significance Index: -2.2400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2071
    Cell Significance Index: -2.2200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.2142
    Cell Significance Index: -2.3600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2179
    Cell Significance Index: -2.7200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2181
    Cell Significance Index: -2.2500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2193
    Cell Significance Index: -1.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2194
    Cell Significance Index: -2.3900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2224
    Cell Significance Index: -2.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2270
    Cell Significance Index: -2.6800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2289
    Cell Significance Index: -2.3900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2294
    Cell Significance Index: -2.8200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2360
    Cell Significance Index: -2.7100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2408
    Cell Significance Index: -2.7200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2521
    Cell Significance Index: -2.8600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2522
    Cell Significance Index: -2.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2795
    Cell Significance Index: -2.1500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2903
    Cell Significance Index: -2.7200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3029
    Cell Significance Index: -2.7300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3258
    Cell Significance Index: -2.8700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3558
    Cell Significance Index: -2.7200
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.3564
    Cell Significance Index: -3.2800
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.3616
    Cell Significance Index: -2.5900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5116
    Cell Significance Index: -4.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MKRN7P, a pseudogene, is a non-functional copy of the MKRN7 gene, which encodes a makorin ring finger protein. Unlike its functional counterpart, MKRN7P lacks the coding capacity for a protein and is instead characterized by a non-coding RNA sequence. The high expression levels of MKRN7P in various retinal and prostate cell types suggest that it may play a role in regulating cellular processes, possibly through RNA interference or microRNA-mediated mechanisms. **Pathways and Functions** While the exact mechanisms of MKRN7P are unknown, several pathways and functions can be inferred based on its expression profile and potential regulatory roles: 1. **Retinal Development and Function**: MKRN7P's expression in retinal ganglion cells, bipolar neurons, and other retinal cell types suggests that it may be involved in regulating retinal development, synaptic plasticity, or photoreceptor function. 2. **Cellular Stress Response**: The presence of MKRN7P in ependymal cells and prostate epithelial cells implies that it may be involved in responding to cellular stress, such as oxidative stress or hypoxia. 3. **RNA Regulation**: MKRN7P's pseudogene status suggests that it may act as a decoy RNA or a scaffold for RNA-binding proteins, influencing the regulation of gene expression and microRNA-mediated processes. **Clinical Significance** The identification of MKRN7P as a significantly expressed pseudogene has significant implications for our understanding of retinal and prostate diseases: 1. **Retinal Diseases**: MKRN7P's role in retinal development and function may be critical in understanding the pathogenesis of retinal diseases, such as retinitis pigmentosa or age-related macular degeneration. 2. **Prostate Cancer**: The expression of MKRN7P in prostate epithelial cells suggests that it may be involved in the development or progression of prostate cancer, potentially as a tumor suppressor or oncogene. 3. **Neurodegenerative Diseases**: MKRN7P's presence in retinal ganglion cells may also be relevant to neurodegenerative diseases, such as glaucoma or Alzheimer's disease, which affect the retina and brain. In conclusion, the MKRN7P pseudogene is a fascinating and enigmatic gene that warrants further investigation. Through a deeper understanding of its pathways and functions, we may uncover novel therapeutic targets for retinal and prostate diseases, as well as neurodegenerative disorders. As an expert immunologist, I am eager to continue exploring the uncharted territory of MKRN7P and unravel its secrets.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.