Details for: H3 4

Gene ID: 8290

Symbol: H3 4

Ensembl ID: ENSG00000168148

Description: H3.4 histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6854
    Cell Significance Index: 5.1800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0589
    Cell Significance Index: 0.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0468
    Cell Significance Index: 0.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0378
    Cell Significance Index: 0.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0266
    Cell Significance Index: 0.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0097
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0075
    Cell Significance Index: 0.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.0025
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0043
    Cell Significance Index: -0.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0058
    Cell Significance Index: -0.1900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0065
    Cell Significance Index: -0.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0091
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0098
    Cell Significance Index: -0.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0116
    Cell Significance Index: -0.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0117
    Cell Significance Index: -0.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0117
    Cell Significance Index: -0.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0121
    Cell Significance Index: -0.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0135
    Cell Significance Index: -0.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0147
    Cell Significance Index: -0.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0149
    Cell Significance Index: -0.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0150
    Cell Significance Index: -0.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0157
    Cell Significance Index: -0.1600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0172
    Cell Significance Index: -0.1800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0177
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0185
    Cell Significance Index: -0.2300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0190
    Cell Significance Index: -0.2300
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0191
    Cell Significance Index: -0.2400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0193
    Cell Significance Index: -0.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0193
    Cell Significance Index: -0.2800
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0194
    Cell Significance Index: -0.2400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0197
    Cell Significance Index: -0.2400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0204
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0214
    Cell Significance Index: -0.1900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0216
    Cell Significance Index: -0.1500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0216
    Cell Significance Index: -0.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0225
    Cell Significance Index: -0.2300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0230
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0233
    Cell Significance Index: -0.2100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0238
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0279
    Cell Significance Index: -0.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0293
    Cell Significance Index: -0.3200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0312
    Cell Significance Index: -0.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0318
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0322
    Cell Significance Index: -0.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0327
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0333
    Cell Significance Index: -0.6900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0359
    Cell Significance Index: -0.3200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0362
    Cell Significance Index: -0.3000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0375
    Cell Significance Index: -0.5000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0391
    Cell Significance Index: -0.1900
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0394
    Cell Significance Index: -0.1900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0425
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Histone H3.4 is a histone protein with a conserved amino acid sequence, sharing high sequence identity with other histone H3 family members. It is a core histone protein, meaning it is a fundamental component of chromatin structure. H3.4 is specifically expressed in germ cells, oogonial cells, male germ cells, oocytes, primordial germ cells, and certain epithelial cells, such as those found in the kidney and pericytes. **Pathways and Functions:** Histone H3.4 is involved in various cellular processes, including: 1. **DNA Repair:** H3.4 plays a crucial role in base excision repair (BER) and nucleotide excision repair (NER), two essential pathways for repairing DNA damage. 2. **Cell Cycle Regulation:** H3.4 is involved in regulating the cell cycle, particularly during the G2/M phase, where it interacts with proteins involved in DNA damage response and repair. 3. **Chromatin Organization:** H3.4 contributes to chromatin organization by interacting with other histones and chromatin-modifying enzymes, influencing gene expression and chromatin structure. 4. **Telomere Maintenance:** H3.4 is involved in telomere maintenance, including the packaging of telomere ends and the recruitment of proteins involved in telomere length maintenance. **Clinical Significance:** Dysregulation of Histone H3.4 has been implicated in various diseases, including: 1. **Cancer:** Alterations in H3.4 expression have been observed in several types of cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases:** H3.4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where chromatin dysfunction and DNA damage contribute to disease progression. 3. **Genetic Disorders:** Mutations in H3.4 have been associated with genetic disorders, such as Fanconi anemia, a disorder characterized by bone marrow failure and increased risk of cancer. In conclusion, Histone H3.4 is a multifunctional protein that plays a critical role in chromatin organization, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms and function in maintaining genome stability and overall cellular homeostasis.

Genular Protein ID: 111588513

Symbol: H31T_HUMAN

Name: Histone H3.1t

UniProtKB Accession Codes:

Q16695 B2R5K3 Q6FGU4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 15 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8834248

Title: A solitary human H3 histone gene on chromosome 1.

PubMed ID: 8834248

DOI: 10.1007/bf02267072

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20850016

Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

PubMed ID: 20850016

DOI: 10.1016/j.cell.2010.08.020

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

Sequence Information:

  • Length: 136
  • Mass: 15508
  • Checksum: 37375A2C3A377B2B
  • Sequence:
    • MARTKQTARK STGGKAPRKQ LATKVARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 
LLIRKLPFQR LMREIAQDFK TDLRFQSSAV MALQEACESY LVGLFEDTNL CVIHAKRVTI 
MPKDIQLARR IRGERA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.