Details for: HIP1R
Gene ID: 9026
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HIP1R
Ensembl ID: ENSG00000130787
Description: huntingtin interacting protein 1 related
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 17.34rCSI 26.49%PRS 68.8
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CSI 14.67rCSI 26.65%PRS 56.26
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CSI 11.93rCSI 27.8%PRS 75.38
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CSI 10.84rCSI 23.06%PRS 63.19
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CSI 6.46rCSI 16.78%PRS 67.93
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CSI 5.59rCSI 12.31%PRS 47.34
-
CSI 4.45rCSI 6.8%PRS 65.3
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CSI 3.88rCSI 8.69%PRS 46.7
-
CSI 3.64rCSI 2.69%PRS 57.12
-
CSI 3.43rCSI 2.56%PRS 80.65
-
CSI 3.31rCSI 2.79%PRS 81.11
-
CSI 3.31rCSI 2.3%PRS 75.72
-
CSI 3.02rCSI 2.97%PRS 67.31
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CSI 2.92rCSI 12.39%PRS 57.69
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CSI 2.84rCSI 6.67%PRS 68.63
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CSI 2.84rCSI 4.07%PRS 67.57
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CSI 2.8rCSI 5.08%PRS 79.05
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CSI 2.71rCSI 2.37%PRS 73.71
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CSI 2.67rCSI 5.28%PRS 79.74
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CSI 2.63rCSI 5.27%PRS 53.56
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CSI 2.62rCSI 2.52%PRS 84.89
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CSI 2.6rCSI 4.49%PRS 54.65
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CSI 2.56rCSI 3.42%PRS 73.46
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CSI 2.42rCSI 2.52%PRS 64.93
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CSI 2.4rCSI 3.4%PRS 60.95
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CSI 2.38rCSI 2.55%PRS 64.41
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CSI 2.35rCSI 1.75%PRS 77.86
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CSI 2.35rCSI 1.94%PRS 66.98
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CSI 2.32rCSI 3.34%PRS 74.88
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CSI 2.3rCSI 4.9%PRS 75.12
-
CSI 2.29rCSI 5.49%PRS 73.98
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CSI 2.25rCSI 8.75%PRS 68.64
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CSI 2.2rCSI 1.83%PRS 64.03
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CSI 2.16rCSI 5.45%PRS 72.32
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CSI 2.15rCSI 5.62%PRS 67.49
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CSI 2.15rCSI 5.1%PRS 67.83
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CSI 2.15rCSI 1.89%PRS 52.5
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CSI 2.15rCSI 2.61%PRS 72.09
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CSI 2.14rCSI 1.9%PRS 62.48
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CSI 2.12rCSI 1.43%PRS 77.75
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CSI 2.09rCSI 2.85%PRS 56.18
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CSI 2.09rCSI 2.6%PRS 66.21
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CSI 2rCSI 4.15%PRS 61.72
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CSI 1.99rCSI 1.88%PRS 63.95
-
CSI 1.94rCSI 4.43%PRS 60.67
-
CSI 1.94rCSI 2.5%PRS 47.28
-
CSI 1.93rCSI 3.13%PRS 61.01
-
CSI 1.91rCSI 1.51%PRS 71.28
-
CSI 1.81rCSI 2.09%PRS 54.95
-
CSI 1.8rCSI 2.15%PRS 45.81
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CSI 1.76rCSI 3.12%PRS 45.1
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CSI 1.75rCSI 1.52%PRS 75.29
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CSI 1.73rCSI 4.51%PRS 61.48
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CSI 1.7rCSI 1.64%PRS 55.43
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CSI 1.63rCSI 2.92%PRS 63.72
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CSI 1.63rCSI 2.17%PRS 70.98
-
CSI 1.62rCSI 1.9%PRS 66.67
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CSI 1.61rCSI 2.19%PRS 75.89
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CSI 1.6rCSI 1.67%PRS 60.96
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CSI 1.59rCSI 4.7%PRS 67.28
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CSI 1.59rCSI 3.93%PRS 63.1
-
CSI 1.58rCSI 3.59%PRS 56.16
-
CSI 1.56rCSI 1.94%PRS 44.17
-
CSI 1.54rCSI 1.91%PRS 61.27
-
CSI 1.54rCSI 2.21%PRS 54.13
-
CSI 1.54rCSI 3.76%PRS 57.7
-
CSI 1.48rCSI 3.52%PRS 65.18
-
CSI 1.47rCSI 2.46%PRS 45.99
-
CSI 1.41rCSI 5.06%PRS 44.3
-
CSI 1.33rCSI 1.82%PRS 66.02
-
CSI 1.32rCSI 3.4%PRS 59.56
-
CSI 1.31rCSI 2.54%PRS 67.53
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CSI 1.27rCSI 1.94%PRS 61.02
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CSI 1.23rCSI 1.97%PRS 47.93
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CSI 1.21rCSI 4.55%PRS 50.22
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CSI 1.16rCSI 2.95%PRS 53.97
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CSI 1.16rCSI 4.66%PRS 63.49
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CSI 1.13rCSI 1.65%PRS 69.62
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CSI 1.08rCSI 2.57%PRS 73.04
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CSI 1.07rCSI 3.11%PRS 54.08
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CSI 1.06rCSI 2.33%PRS 72.34
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CSI 0.97rCSI 2.13%PRS 50.55
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CSI 0.96rCSI 2.59%PRS 71.5
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CSI 0.95rCSI 1.3%PRS 57.68
-
CSI 0.71rCSI 1.9%PRS 55.54
-
CSI 0.71rCSI 2.03%PRS 75.4
-
CSI 0.71rCSI 2.44%PRS 53.09
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CSI 0.66rCSI 15.39%PRS 82.32
-
CSI 0.66rCSI 3.79%PRS 77.79
-
CSI 0.64rCSI 1.56%PRS 44.47
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CSI 0.61rCSI 1.72%PRS 75.2
-
CSI 0.56rCSI 3.87%PRS 76.7
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CSI 0.55rCSI 1.72%PRS 47.65
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CSI 0.53rCSI 1.67%PRS 50.08
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CSI 0.46rCSI 1.72%PRS 46.68
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CSI 0.45rCSI 3.33%PRS 51.03
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CSI 0.32rCSI 4.6%PRS 55.49
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CSI 0.27rCSI 1.6%PRS 47.13
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CSI 0.25rCSI 2.69%PRS 62.65
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 829661105
Symbol: HIP1R_HUMAN
Name: Huntingtin-interacting protein 1-related protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11063258
Title: HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
PubMed ID: 11063258
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9852681
Title: Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).
PubMed ID: 9852681
PubMed ID: 11889126
Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
PubMed ID: 11889126
PubMed ID: 14732715
Title: HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.
PubMed ID: 14732715
PubMed ID: 15533940
Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
PubMed ID: 15533940
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19255499
Title: HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death.
PubMed ID: 19255499
DOI: 10.1159/000204088
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 16415883
Title: Structural definition of the F-actin-binding THATCH domain from HIP1R.
PubMed ID: 16415883
DOI: 10.1038/nsmb1043
Sequence Information:
- Length: 1068
- Mass: 119388
- Checksum: 3CBC7CF1191BFF8F
- Sequence:
MNSIKNVPAR VLSRRPGHSL EAEREQFDKT QAISISKAIN TQEAPVKEKH ARRIILGTHH EKGAFTFWSY AIGLPLPSSS ILSWKFCHVL HKVLRDGHPN VLHDCQRYRS NIREIGDLWG HLHDRYGQLV NVYTKLLLTK ISFHLKHPQF PAGLEVTDEV LEKAAGTDVN NIFQLTVEMF DYMDCELKLS ESVFRQLNTA IAVSQMSSGQ CRLAPLIQVI QDCSHLYHYT VKLLFKLHSC LPADTLQGHR DRFHEQFHSL RNFFRRASDM LYFKRLIQIP RLPEGPPNFL RASALAEHIK PVVVIPEEAP EDEEPENLIE ISTGPPAGEP VVVADLFDQT FGPPNGSVKD DRDLQIESLK REVEMLRSEL EKIKLEAQRY IAQLKSQVNA LEGELEEQRK QKQKALVDNE QLRHELAQLR AAQLEGERSQ GLREEAERKA SATEARYNKL KEKHSELVHV HAELLRKNAD TAKQLTVTQQ SQEEVARVKE QLAFQVEQVK RESELKLEEK SDQLEKLKRE LEAKAGELAR AQEALSHTEQ SKSELSSRLD TLSAEKDALS GAVRQREADL LAAQSLVRET EAALSREQQR SSQEQGELQG RLAERESQEQ GLRQRLLDEQ FAVLRGAAAE AAGILQDAVS KLDDPLHLRC TSSPDYLVSR AQEALDAVST LEEGHAQYLT SLADASALVA ALTRFSHLAA DTIINGGATS HLAPTDPADR LIDTCRECGA RALELMGQLQ DQQALRHMQA SLVRTPLQGI LQLGQELKPK SLDVRQEELG AVVDKEMAAT SAAIEDAVRR IEDMMNQARH ASSGVKLEVN ERILNSCTDL MKAIRLLVTT STSLQKEIVE SGRGAATQQE FYAKNSRWTE GLISASKAVG WGATQLVEAA DKVVLHTGKY EELIVCSHEI AASTAQLVAA SKVKANKHSP HLSRLQECSR TVNERAANVV ASTKSGQEQI EDRDTMDFSG LSLIKLKKQE METQVRVLEL EKTLEAERMR LGELRKQHYV LAGASGSPGE EVAIRPSTAP RSVTTKKPPL AQKPSVAPRQ DHQLDKKDGI YPAQLVNY
Genular Protein ID: 2834164015
Symbol: B4DPL0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 437
- Mass: 49989
- Checksum: CEBAD372641755D2
- Sequence:
MFDYMDCELK LSESVFRQLN TAIAVSQMSS GQCRLAPLIQ VIQDCSHLYH YTVKLLFKLH SCLPADTLQG HRDRFHEQFH SLRNFFRRAS DMLYFKRLIQ IPRLPEGPPN FLRASALAEH IKPVVVIPEE APEDEEPENL IEISTGPPAG EPVVVADLFD QTFGPPNGSV KDDRDLQIES LKREVEMLRS ELEKIKLEAQ RYIAQLKSQV NALEGELEEQ RKQKQKALVD NEQLRHELAQ LRAAQLEGER SQGLREEAER KASATEARYN KLKEKHSELV HVHAELLRKN ADTAKQLTVT QQSQEEVARV KEQLAFQVEQ VKRESELKLE EKSDQLEKLK RELEAKAGEL ARAQEALSHT EQSKSELSSR LDTLSAEKDA LSGAVRQREA DLLAAQSLVR ETEAALSREQ QRSSQEQGEL QGRLAERVWP PQMQQHH
Genular Protein ID: 836410272
Symbol: B3KQW8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 603
- Mass: 69010
- Checksum: 32F819D582ED22A6
- Sequence:
MEARFSPINQ ILPWCRQDLA ISISKAINTQ EAPVKEKHAR RIILGTHHEK GAFTFWSYAI GLPLPSSSIL SWKFCHVLHK VLRDGHPNVL HDCQRYRSNI REIGDLWGHL HDRYGQLVNV YTKLLLTKIS FHLKHPQFPA GLEVTDEVLE KAAGTDVNNI FQLTVEMFDY MDCELKLSES VFRQLNTAIA VSQMSSGQCR LAPLIQVIQD CSHLYHYTVK LLFKLHSCLP ADTLQGHRDR FHEQFHSLRN FFRRASDMLY FKRLIQIPRL PEGPPNFLRA SALAEHIKPV VVIPEEAPED EEPENLIEIS TGPPAGEPVV VADLFDQTFG PPNGSVKDDR DLQIESLKRE VEMLRSELEK IKLEAQRYIA QLKSQVNALE GELEEQRKQK QKALVDNEQL RHELAQLRAA QLEGERSQGL REEAERKASA TEARYNKLKE KHSELVHVHA ELLRKNADTA KQLTVTQQSQ EEVARVKEQL AFQVEQVKRE SELKLEEKSD QLEKLKRELE AKAGELARAQ EALSHTEQSK SELSSRLDTL SAEKDALSGA VRQREADLLA AQSLVRETEA ALSREQQRSS QEQGELQGRL AERVWPPQMQ QHH