Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 5.74
Marker Score: 14,596 - Cell Name: malignant cell (CL0001064)
Fold Change: 5.64
Marker Score: 75,753 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.59
Marker Score: 11,726 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.52
Marker Score: 7,187 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.48
Marker Score: 8,439 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.45
Marker Score: 15,895 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 5.44
Marker Score: 1,385 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.41
Marker Score: 4,233 - Cell Name: mature T cell (CL0002419)
Fold Change: 5.37
Marker Score: 53,150 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.19
Marker Score: 8,899 - Cell Name: naive B cell (CL0000788)
Fold Change: 5.11
Marker Score: 4,567 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.09
Marker Score: 3,692 - Cell Name: naive T cell (CL0000898)
Fold Change: 4.91
Marker Score: 3,163 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.86
Marker Score: 1,162 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.85
Marker Score: 15,316 - Cell Name: myelocyte (CL0002193)
Fold Change: 4.83
Marker Score: 2,089 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.83
Marker Score: 2,480 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.76
Marker Score: 251,774 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 4.72
Marker Score: 3,576 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.66
Marker Score: 260,312 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.63
Marker Score: 5,142 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.61
Marker Score: 24,234 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 4.59
Marker Score: 4,379 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.58
Marker Score: 29,195 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.57
Marker Score: 5,503 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.55
Marker Score: 5,620 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.53
Marker Score: 12,133 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 4.51
Marker Score: 1,169 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.5
Marker Score: 6,507 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.49
Marker Score: 59,270 - Cell Name: secretory cell (CL0000151)
Fold Change: 4.49
Marker Score: 8,191 - Cell Name: theca cell (CL0000503)
Fold Change: 4.48
Marker Score: 3,209 - Cell Name: neutrophil (CL0000775)
Fold Change: 4.45
Marker Score: 2,712 - Cell Name: granulocyte (CL0000094)
Fold Change: 4.45
Marker Score: 1,994 - Cell Name: blood cell (CL0000081)
Fold Change: 4.41
Marker Score: 51,316 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.39
Marker Score: 2,672 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 4.39
Marker Score: 1,162 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.38
Marker Score: 3,113 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.37
Marker Score: 11,033 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 4.37
Marker Score: 3,711 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.37
Marker Score: 1,421 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.37
Marker Score: 10,675 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.36
Marker Score: 15,497 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.34
Marker Score: 11,982 - Cell Name: endothelial cell (CL0000115)
Fold Change: 4.32
Marker Score: 3,876 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.32
Marker Score: 990 - Cell Name: memory T cell (CL0000813)
Fold Change: 4.3
Marker Score: 1,849 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 4.29
Marker Score: 17,878 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.28
Marker Score: 4,141 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.25
Marker Score: 11,915 - Cell Name: chondrocyte (CL0000138)
Fold Change: 4.21
Marker Score: 1,897 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.2
Marker Score: 2,464 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 4.19
Marker Score: 5,054 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.14
Marker Score: 3,248 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 4.14
Marker Score: 4,451 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.13
Marker Score: 10,069 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 4.1
Marker Score: 1,671 - Cell Name: fibroblast (CL0000057)
Fold Change: 4.1
Marker Score: 3,959 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.09
Marker Score: 35,901 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.09
Marker Score: 6,017 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.08
Marker Score: 17,513 - Cell Name: supporting cell (CL0000630)
Fold Change: 4.08
Marker Score: 7,667 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 4.07
Marker Score: 3,337 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 4.07
Marker Score: 3,499 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 4.06
Marker Score: 4,419 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.05
Marker Score: 137,943 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.04
Marker Score: 4,315 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 4.03
Marker Score: 1,060 - Cell Name: reticular cell (CL0000432)
Fold Change: 4.01
Marker Score: 1,465 - Cell Name: ependymal cell (CL0000065)
Fold Change: 4.01
Marker Score: 1,400 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4
Marker Score: 26,103 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4
Marker Score: 3,777 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.99
Marker Score: 3,521 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.98
Marker Score: 1,131 - Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.98
Marker Score: 990 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.98
Marker Score: 29,620 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.97
Marker Score: 1,053 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.96
Marker Score: 1,130 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 3.96
Marker Score: 1,430 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.95
Marker Score: 1,269 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 3.94
Marker Score: 1,790 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 3.93
Marker Score: 1,640 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.93
Marker Score: 2,415 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 3.92
Marker Score: 853 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.91
Marker Score: 3,438 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.91
Marker Score: 4,722 - Cell Name: S cone cell (CL0003050)
Fold Change: 3.91
Marker Score: 1,174 - Cell Name: club cell (CL0000158)
Fold Change: 3.9
Marker Score: 4,556 - Cell Name: stromal cell (CL0000499)
Fold Change: 3.9
Marker Score: 4,571 - Cell Name: tendon cell (CL0000388)
Fold Change: 3.9
Marker Score: 959 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.89
Marker Score: 6,952 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 3.89
Marker Score: 762 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.89
Marker Score: 2,013 - Cell Name: platelet (CL0000233)
Fold Change: 3.89
Marker Score: 1,759 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 3.87
Marker Score: 964 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.87
Marker Score: 19,022 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 3.87
Marker Score: 992 - Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 3.87
Marker Score: 1,092 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 3.87
Marker Score: 939 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.86
Marker Score: 3,210
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2192474367
Symbol: ACTB_HUMAN
Name: Actin, cytoplasmic 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6322116
Title: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.
PubMed ID: 6322116
PubMed ID: 2994062
Title: Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
PubMed ID: 2994062
PubMed ID: 1734024
Title: Direct proof that the primary site of action of cytochalasin on cell motility processes is actin.
PubMed ID: 1734024
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 6842590
Title: Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions.
PubMed ID: 6842590
PubMed ID: 11687588
Title: Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.
PubMed ID: 11687588
PubMed ID: 14592989
Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
PubMed ID: 14592989
DOI: 10.1093/emboj/cdg565
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15328537
Title: Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.
PubMed ID: 15328537
PubMed ID: 16139798
Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
PubMed ID: 16139798
PubMed ID: 17823310
Title: HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.
PubMed ID: 17823310
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 18765789
Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
PubMed ID: 18765789
DOI: 10.1101/gad.471408
PubMed ID: 19015515
Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.
PubMed ID: 19015515
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19377461
Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 19377461
DOI: 10.1038/nature07954
PubMed ID: 24336203
Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 24336203
DOI: 10.1038/nature12896
PubMed ID: 21969592
Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.
PubMed ID: 21969592
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 21555369
Title: Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
PubMed ID: 21555369
PubMed ID: 23673617
Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
PubMed ID: 23673617
DOI: 10.1038/ncomms2863
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26228148
Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
PubMed ID: 26228148
PubMed ID: 28604741
Title: A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma.
PubMed ID: 28604741
DOI: 10.1038/onc.2017.181
PubMed ID: 30028079
Title: NAT6 acetylates the N-terminus of different forms of actin.
PubMed ID: 30028079
DOI: 10.1111/febs.14605
PubMed ID: 29925947
Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.
PubMed ID: 29925947
PubMed ID: 29581253
Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.
PubMed ID: 29581253
PubMed ID: 30526847
Title: SETD3 protein is the actin-specific histidine N-methyltransferase.
PubMed ID: 30526847
DOI: 10.7554/elife.37921
PubMed ID: 29343822
Title: The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.
PubMed ID: 29343822
PubMed ID: 36173861
Title: Actin maturation requires the ACTMAP/C19orf54 protease.
PubMed ID: 36173861
PubMed ID: 30785395
Title: Structural insights into SETD3-mediated histidine methylation on beta-actin.
PubMed ID: 30785395
DOI: 10.7554/elife.43676
PubMed ID: 30626964
Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
PubMed ID: 30626964
PubMed ID: 31388018
Title: Structural basis for the target specificity of actin histidine methyltransferase SETD3.
PubMed ID: 31388018
PubMed ID: 32503840
Title: Characterization of SETD3 methyltransferase-mediated protein methionine methylation.
PubMed ID: 32503840
PubMed ID: 31911441
Title: An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
PubMed ID: 31911441
PubMed ID: 16685646
Title: A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
PubMed ID: 16685646
DOI: 10.1086/504271
PubMed ID: 22366783
Title: De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.
PubMed ID: 22366783
DOI: 10.1038/ng.1091
Sequence Information:
- Length: 375
- Mass: 41737
- Checksum: 6AFD05CA94E360E2
- Sequence:
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.