Details for: GPR50 AS1

Gene ID: 100128688

Symbol: GPR50 AS1

Ensembl ID: ENSG00000234696

Description: GPR50 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.1188
    Cell Significance Index: 19.8200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.8325
    Cell Significance Index: 9.2200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3902
    Cell Significance Index: 5.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2518
    Cell Significance Index: 3.6700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1508
    Cell Significance Index: 1.1600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0861
    Cell Significance Index: 0.8300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0237
    Cell Significance Index: 0.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0047
    Cell Significance Index: -0.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0068
    Cell Significance Index: -0.9400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0116
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0121
    Cell Significance Index: -0.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0124
    Cell Significance Index: -0.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0161
    Cell Significance Index: -0.1600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0167
    Cell Significance Index: -0.1600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0170
    Cell Significance Index: -0.1600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0172
    Cell Significance Index: -0.1700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0184
    Cell Significance Index: -0.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0188
    Cell Significance Index: -0.1600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0191
    Cell Significance Index: -0.1700
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0194
    Cell Significance Index: -0.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0198
    Cell Significance Index: -0.2400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0198
    Cell Significance Index: -0.2100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0202
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0212
    Cell Significance Index: -0.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0214
    Cell Significance Index: -0.1700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0223
    Cell Significance Index: -0.1700
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0227
    Cell Significance Index: -0.2300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0236
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0244
    Cell Significance Index: -0.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0261
    Cell Significance Index: -0.1700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0262
    Cell Significance Index: -0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0278
    Cell Significance Index: -0.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0287
    Cell Significance Index: -0.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0306
    Cell Significance Index: -0.7400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0311
    Cell Significance Index: -0.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0316
    Cell Significance Index: -0.8300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0339
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0347
    Cell Significance Index: -0.2100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0357
    Cell Significance Index: -0.4000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0376
    Cell Significance Index: -0.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0379
    Cell Significance Index: -0.8300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0381
    Cell Significance Index: -0.2200
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0399
    Cell Significance Index: -0.2400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0400
    Cell Significance Index: -0.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0408
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0416
    Cell Significance Index: -1.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0419
    Cell Significance Index: -0.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0440
    Cell Significance Index: -0.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0532
    Cell Significance Index: -0.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0556
    Cell Significance Index: -0.5900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0557
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0559
    Cell Significance Index: -0.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0565
    Cell Significance Index: -0.9500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0571
    Cell Significance Index: -0.7200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0582
    Cell Significance Index: -1.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0605
    Cell Significance Index: -0.8300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0616
    Cell Significance Index: -0.6800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0647
    Cell Significance Index: -0.7400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0665
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0689
    Cell Significance Index: -0.8000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0713
    Cell Significance Index: -0.8900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0716
    Cell Significance Index: -0.8800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0731
    Cell Significance Index: -0.8900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0737
    Cell Significance Index: -0.8700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0740
    Cell Significance Index: -0.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0747
    Cell Significance Index: -0.8900
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0750
    Cell Significance Index: -0.8600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0767
    Cell Significance Index: -0.4800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0772
    Cell Significance Index: -0.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0775
    Cell Significance Index: -1.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0783
    Cell Significance Index: -0.8400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0792
    Cell Significance Index: -0.8300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0803
    Cell Significance Index: -0.7300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0804
    Cell Significance Index: -1.0400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0845
    Cell Significance Index: -0.8800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0853
    Cell Significance Index: -0.8800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0972
    Cell Significance Index: -0.8500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0976
    Cell Significance Index: -1.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0977
    Cell Significance Index: -0.7800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1006
    Cell Significance Index: -0.8500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.1007
    Cell Significance Index: -1.1000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1017
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1018
    Cell Significance Index: -1.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The GPR50 AS1 gene is characterized by its antisense RNA 1 expression pattern, which implies that it plays a regulatory role in the expression of nearby genes. The gene's widespread expression across various cell types suggests that it may be involved in maintaining tissue homeostasis and regulating cellular processes. Notably, GPR50 AS1 is significantly expressed in cells of the immune system, including microglial cells and blood vessel endothelial cells, which highlights its potential role in immune regulation. **Pathways and Functions:** The functions of GPR50 AS1 are not yet fully understood, but its expression in various cell types suggests that it may be involved in regulating cellular processes such as cell proliferation, differentiation, and survival. Several signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, have been implicated in the regulation of GPR50 AS1 expression. These pathways are critical in regulating cellular responses to stimuli, including immune responses. One potential function of GPR50 AS1 is its role in regulating the immune response. Microglial cells, which are a type of immune cell found in the brain, have been shown to express GPR50 AS1, suggesting that this gene may play a role in regulating microglial function and immune responses in the central nervous system. Additionally, GPR50 AS1 may also be involved in regulating the function of blood vessel endothelial cells, which are critical in maintaining vascular homeostasis. **Clinical Significance:** The clinical significance of GPR50 AS1 is an area of ongoing research. Given its expression in various cell types, including immune cells, GPR50 AS1 may play a role in regulating immune responses and maintaining tissue homeostasis. Dysregulation of GPR50 AS1 expression has been implicated in several diseases, including autoimmune disorders and cancer. For example, studies have shown that GPR50 AS1 is downregulated in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. Additionally, GPR50 AS1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting that it may play a role in tumor progression and metastasis. In conclusion, GPR50 AS1 is a gene of ongoing immunological significance that plays a complex role in regulating cellular processes, including cell proliferation, differentiation, and survival. Further research is needed to fully understand the functions and clinical significance of GPR50 AS1, but its expression in various cell types suggests that it may be involved in regulating immune responses and maintaining tissue homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.