Details for: CST8

Gene ID: 10047

Symbol: CST8

Ensembl ID: ENSG00000125815

Description: cystatin 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.57
    Marker Score: 103,761
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,071
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,280
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,846
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,181
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.05
    Marker Score: 615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,061
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1,401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,455
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.71
    Marker Score: 758
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 251
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.41
    Marker Score: 6,401
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.34
    Marker Score: 2,042
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.3
    Marker Score: 813
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 179
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 193
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.07
    Marker Score: 194
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 54
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 51
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CST8 is a small, cysteine-rich protein with a molecular weight of approximately 10 kDa. It is secreted by various cell types and has been shown to inhibit cysteine proteases, including cathepsins and granzymes. CST8 is highly conserved across species, with high sequence identity among mammals. Its expression is widespread, with significant levels detected in the brain, heart, and peripheral tissues. **Pathways and Functions:** CST8 has been implicated in several cellular pathways, including: 1. **Cell proliferation and differentiation**: CST8 has been shown to regulate cell proliferation and differentiation in various cell types, including progenitor cells and oligodendrocyte precursor cells. 2. **Apoptosis**: CST8 has been shown to inhibit apoptosis in certain cell types, including microglial cells and endothelial cells. 3. **Inflammation**: CST8 has anti-inflammatory properties, with studies suggesting that it can regulate the production of pro-inflammatory cytokines. 4. **Cell migration and invasion**: CST8 has been shown to regulate cell migration and invasion in various cell types, including cancer cells. **Clinical Significance:** CST8 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: CST8 has been shown to play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Abnormal CST8 expression has been linked to cognitive decline and neuronal loss. 2. **Cancer**: CST8 has been shown to regulate cell proliferation and invasion in various cancer types, including breast cancer and prostate cancer. 3. **Cardiovascular disease**: CST8 has been implicated in cardiovascular disease, with studies suggesting that it can regulate endothelial cell function and prevent atherosclerosis. 4. **Inflammatory diseases**: CST8 has anti-inflammatory properties, with studies suggesting that it can regulate the production of pro-inflammatory cytokines and prevent inflammatory tissue damage. In conclusion, CST8 is a multifunctional protein that plays a crucial role in regulating various cellular processes. Its widespread expression in different cell types and its involvement in various diseases and disorders make it an important target for therapeutic intervention. Further studies are needed to fully elucidate the functions and clinical implications of CST8.

Genular Protein ID: 3678307213

Symbol: CST8_HUMAN

Name: Cystatin-8

UniProtKB Accession Codes:

O60676 Q2M2X6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7619504

Title: Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation.

PubMed ID: 7619504

DOI: 10.1002/mrd.1080410107

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

Sequence Information:

  • Length: 142
  • Mass: 16275
  • Checksum: 9A3512757E0F4ECD
  • Sequence:
    • MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW FAMQEYNKES 
EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS TNEICAIQEN SKLKRKLSCS 
FLVGALPWNG EFTVMEKKCE DA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.