Details for: CST8

Gene ID: 10047

Symbol: CST8

Ensembl ID: ENSG00000125815

Description: cystatin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1922
    Cell Significance Index: 1.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1556
    Cell Significance Index: 3.8900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1418
    Cell Significance Index: 1.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0998
    Cell Significance Index: 1.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0913
    Cell Significance Index: 1.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0538
    Cell Significance Index: 0.7700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0214
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0130
    Cell Significance Index: 0.5900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0125
    Cell Significance Index: 0.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0098
    Cell Significance Index: 1.1500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0077
    Cell Significance Index: 0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0017
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0041
    Cell Significance Index: -0.8200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0087
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0146
    Cell Significance Index: -0.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0155
    Cell Significance Index: -0.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0178
    Cell Significance Index: -0.1700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0181
    Cell Significance Index: -0.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0184
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0200
    Cell Significance Index: -0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0224
    Cell Significance Index: -0.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0241
    Cell Significance Index: -0.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0275
    Cell Significance Index: -0.2000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0292
    Cell Significance Index: -0.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0303
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0303
    Cell Significance Index: -0.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0310
    Cell Significance Index: -0.3700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0314
    Cell Significance Index: -0.3900
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0318
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0322
    Cell Significance Index: -0.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0325
    Cell Significance Index: -0.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0326
    Cell Significance Index: -0.6900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0332
    Cell Significance Index: -0.4100
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0335
    Cell Significance Index: -0.3900
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0335
    Cell Significance Index: -0.4100
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0341
    Cell Significance Index: -1.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0349
    Cell Significance Index: -0.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0358
    Cell Significance Index: -0.3900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0361
    Cell Significance Index: -0.3900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0367
    Cell Significance Index: -0.4400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0370
    Cell Significance Index: -0.3900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0381
    Cell Significance Index: -0.4100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0382
    Cell Significance Index: -0.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0403
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0406
    Cell Significance Index: -0.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0413
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0418
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0423
    Cell Significance Index: -0.7300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0423
    Cell Significance Index: -0.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0425
    Cell Significance Index: -0.8400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0426
    Cell Significance Index: -0.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0472
    Cell Significance Index: -0.4500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0473
    Cell Significance Index: -0.3800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0504
    Cell Significance Index: -0.2700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0572
    Cell Significance Index: -0.5000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0572
    Cell Significance Index: -0.4700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0591
    Cell Significance Index: -0.4100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0616
    Cell Significance Index: -0.5500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0618
    Cell Significance Index: -0.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0626
    Cell Significance Index: -0.7900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0631
    Cell Significance Index: -0.6700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0639
    Cell Significance Index: -0.7000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0663
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0667
    Cell Significance Index: -0.8200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0679
    Cell Significance Index: -0.4300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0752
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0872
    Cell Significance Index: -0.8200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0896
    Cell Significance Index: -0.4100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0900
    Cell Significance Index: -0.8200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0930
    Cell Significance Index: -1.1700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0931
    Cell Significance Index: -0.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0942
    Cell Significance Index: -0.5800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0965
    Cell Significance Index: -0.8500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0977
    Cell Significance Index: -0.9300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0996
    Cell Significance Index: -1.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1039
    Cell Significance Index: -1.2600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1049
    Cell Significance Index: -1.0700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1103
    Cell Significance Index: -1.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CST8 is a small, cysteine-rich protein with a molecular weight of approximately 10 kDa. It is secreted by various cell types and has been shown to inhibit cysteine proteases, including cathepsins and granzymes. CST8 is highly conserved across species, with high sequence identity among mammals. Its expression is widespread, with significant levels detected in the brain, heart, and peripheral tissues. **Pathways and Functions:** CST8 has been implicated in several cellular pathways, including: 1. **Cell proliferation and differentiation**: CST8 has been shown to regulate cell proliferation and differentiation in various cell types, including progenitor cells and oligodendrocyte precursor cells. 2. **Apoptosis**: CST8 has been shown to inhibit apoptosis in certain cell types, including microglial cells and endothelial cells. 3. **Inflammation**: CST8 has anti-inflammatory properties, with studies suggesting that it can regulate the production of pro-inflammatory cytokines. 4. **Cell migration and invasion**: CST8 has been shown to regulate cell migration and invasion in various cell types, including cancer cells. **Clinical Significance:** CST8 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: CST8 has been shown to play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Abnormal CST8 expression has been linked to cognitive decline and neuronal loss. 2. **Cancer**: CST8 has been shown to regulate cell proliferation and invasion in various cancer types, including breast cancer and prostate cancer. 3. **Cardiovascular disease**: CST8 has been implicated in cardiovascular disease, with studies suggesting that it can regulate endothelial cell function and prevent atherosclerosis. 4. **Inflammatory diseases**: CST8 has anti-inflammatory properties, with studies suggesting that it can regulate the production of pro-inflammatory cytokines and prevent inflammatory tissue damage. In conclusion, CST8 is a multifunctional protein that plays a crucial role in regulating various cellular processes. Its widespread expression in different cell types and its involvement in various diseases and disorders make it an important target for therapeutic intervention. Further studies are needed to fully elucidate the functions and clinical implications of CST8.

Genular Protein ID: 3678307213

Symbol: CST8_HUMAN

Name: Cystatin-8

UniProtKB Accession Codes:

O60676 Q2M2X6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7619504

Title: Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation.

PubMed ID: 7619504

DOI: 10.1002/mrd.1080410107

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

Sequence Information:

  • Length: 142
  • Mass: 16275
  • Checksum: 9A3512757E0F4ECD
  • Sequence:
    • MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW FAMQEYNKES 
EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS TNEICAIQEN SKLKRKLSCS 
FLVGALPWNG EFTVMEKKCE DA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.