Details for: LINC00410

Gene ID: 144776

Symbol: LINC00410

Ensembl ID: ENSG00000231674

Description: long intergenic non-protein coding RNA 410

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7530
    Cell Significance Index: 22.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5365
    Cell Significance Index: 7.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4847
    Cell Significance Index: 7.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2202
    Cell Significance Index: 2.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1065
    Cell Significance Index: 30.6400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0964
    Cell Significance Index: 1.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0845
    Cell Significance Index: 1.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0578
    Cell Significance Index: 1.5500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0334
    Cell Significance Index: 0.2600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0290
    Cell Significance Index: 0.3500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0225
    Cell Significance Index: 0.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0215
    Cell Significance Index: 0.5200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0207
    Cell Significance Index: 0.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0099
    Cell Significance Index: 0.1600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0018
    Cell Significance Index: 0.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0016
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0016
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0020
    Cell Significance Index: -0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0036
    Cell Significance Index: -0.3700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0049
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0057
    Cell Significance Index: -0.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0057
    Cell Significance Index: -0.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0077
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0087
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0095
    Cell Significance Index: -0.3600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0101
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0117
    Cell Significance Index: -0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0148
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0155
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0156
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0157
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0157
    Cell Significance Index: -0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0158
    Cell Significance Index: -0.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0161
    Cell Significance Index: -0.3400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0171
    Cell Significance Index: -0.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0172
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0176
    Cell Significance Index: -0.2000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0178
    Cell Significance Index: -0.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0183
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0184
    Cell Significance Index: -0.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0210
    Cell Significance Index: -0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0213
    Cell Significance Index: -0.5100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0214
    Cell Significance Index: -0.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0215
    Cell Significance Index: -0.2900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0216
    Cell Significance Index: -0.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0232
    Cell Significance Index: -0.3100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0235
    Cell Significance Index: -0.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0238
    Cell Significance Index: -1.2100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0242
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0243
    Cell Significance Index: -1.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0246
    Cell Significance Index: -0.4900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0248
    Cell Significance Index: -0.3100
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0249
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0256
    Cell Significance Index: -0.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0256
    Cell Significance Index: -0.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0257
    Cell Significance Index: -0.3800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0272
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00410 is a lincRNA, a class of non-coding RNAs that do not encode proteins but regulate gene expression through various mechanisms. It is transcribed from a long intergenic region and is characterized by its long length (approximately 1.5 kilobases) and high expression levels in specific cell types. LINC00410 is predominantly expressed in progenitor cells, endothelial cells, and immune cells, suggesting its role in tissue development, immune regulation, and cell differentiation. **Pathways and Functions:** LINC00410 has been implicated in several signaling pathways that regulate immune cell function, including: 1. **Notch signaling pathway:** LINC00410 has been shown to interact with Notch receptors, modulating their activity and influencing cell fate decisions in progenitor cells and immune cells. 2. **Wnt/β-catenin pathway:** LINC00410 has been implicated in the regulation of Wnt/β-catenin signaling, which is critical for cell proliferation, differentiation, and survival in various tissues, including the immune system. 3. **TGF-β pathway:** LINC00410 has been shown to interact with TGF-β receptors, modulating the activity of this key cytokine in immune cell regulation and tissue development. LINC00410's functions in immune regulation include: 1. **T cell development and function:** LINC00410 has been implicated in the regulation of T cell development, activation, and function, suggesting its role in modulating immune responses. 2. **Immune cell differentiation:** LINC00410 has been shown to influence the differentiation of immune cells, including B cells, plasma cells, and innate lymphoid cells. 3. **Endothelial cell function:** LINC00410 has been implicated in the regulation of endothelial cell function, including angiogenesis and vascular permeability. **Clinical Significance:** LINC00410's dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** LINC00410's dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where immune cell dysfunction and tissue damage are key features. 2. **Cancer:** LINC00410's dysregulation has been implicated in various cancers, including leukemia, lymphoma, and solid tumors, where immune evasion and tumor progression are critical. 3. **Neurological disorders:** LINC00410's dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where immune cell dysfunction and neuroinflammation are key features. In conclusion, LINC00410 is a critical non-coding RNA that regulates immune cell function, tissue development, and disease pathogenesis. Further research is needed to fully elucidate its mechanisms of action and clinical significance, but its potential as a therapeutic target for immune-related disorders is an exciting area of investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.