Details for: CSN3

Gene ID: 1448

Symbol: CSN3

Ensembl ID: ENSG00000171209

Description: casein kappa

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 59.9100
    Cell Significance Index: 257.6300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 1.0703
    Cell Significance Index: 13.2900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.8039
    Cell Significance Index: 8.5400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.5951
    Cell Significance Index: 6.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3981
    Cell Significance Index: 18.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3605
    Cell Significance Index: 46.5700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1787
    Cell Significance Index: 1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1764
    Cell Significance Index: 8.2900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0550
    Cell Significance Index: 0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0267
    Cell Significance Index: 1.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0094
    Cell Significance Index: -1.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0277
    Cell Significance Index: -3.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0288
    Cell Significance Index: -5.7900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0717
    Cell Significance Index: -0.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0741
    Cell Significance Index: -1.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0832
    Cell Significance Index: -16.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0853
    Cell Significance Index: -3.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0893
    Cell Significance Index: -6.0100
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.1014
    Cell Significance Index: -0.8000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1113
    Cell Significance Index: -0.9600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1169
    Cell Significance Index: -1.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1252
    Cell Significance Index: -3.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1393
    Cell Significance Index: -3.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1516
    Cell Significance Index: -3.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1546
    Cell Significance Index: -5.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1570
    Cell Significance Index: -5.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1656
    Cell Significance Index: -5.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1687
    Cell Significance Index: -4.5200
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1817
    Cell Significance Index: -1.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1908
    Cell Significance Index: -3.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1946
    Cell Significance Index: -3.8300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1957
    Cell Significance Index: -2.5200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2008
    Cell Significance Index: -2.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2020
    Cell Significance Index: -5.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2020
    Cell Significance Index: -3.2400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2093
    Cell Significance Index: -2.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2104
    Cell Significance Index: -6.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2151
    Cell Significance Index: -2.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2180
    Cell Significance Index: -4.3100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2301
    Cell Significance Index: -3.1600
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.2331
    Cell Significance Index: -2.2200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2333
    Cell Significance Index: -2.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2333
    Cell Significance Index: -5.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2499
    Cell Significance Index: -3.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2520
    Cell Significance Index: -5.0600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2582
    Cell Significance Index: -3.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2597
    Cell Significance Index: -3.3900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2668
    Cell Significance Index: -3.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2680
    Cell Significance Index: -3.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2728
    Cell Significance Index: -5.7900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2742
    Cell Significance Index: -3.3700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2747
    Cell Significance Index: -2.7800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2813
    Cell Significance Index: -2.5400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2816
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2850
    Cell Significance Index: -3.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2859
    Cell Significance Index: -3.2900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2868
    Cell Significance Index: -5.7200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2904
    Cell Significance Index: -2.2200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2952
    Cell Significance Index: -2.7400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2979
    Cell Significance Index: -3.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3024
    Cell Significance Index: -4.3300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3030
    Cell Significance Index: -3.4500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3052
    Cell Significance Index: -3.6500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3053
    Cell Significance Index: -3.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3056
    Cell Significance Index: -4.0100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3063
    Cell Significance Index: -3.1600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.3127
    Cell Significance Index: -2.8500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3155
    Cell Significance Index: -3.5600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3156
    Cell Significance Index: -3.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3221
    Cell Significance Index: -4.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3228
    Cell Significance Index: -7.8200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3250
    Cell Significance Index: -3.4300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3265
    Cell Significance Index: -3.7800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3290
    Cell Significance Index: -3.5700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3305
    Cell Significance Index: -3.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3341
    Cell Significance Index: -3.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3360
    Cell Significance Index: -4.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3392
    Cell Significance Index: -3.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3409
    Cell Significance Index: -5.7100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3439
    Cell Significance Index: -3.8200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.3475
    Cell Significance Index: -1.6000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3537
    Cell Significance Index: -3.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3540
    Cell Significance Index: -5.0300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.3546
    Cell Significance Index: -3.2800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3578
    Cell Significance Index: -3.8000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3582
    Cell Significance Index: -4.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3595
    Cell Significance Index: -11.3700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3618
    Cell Significance Index: -4.3000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3652
    Cell Significance Index: -3.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3663
    Cell Significance Index: -3.7400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3735
    Cell Significance Index: -5.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3744
    Cell Significance Index: -3.5500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3814
    Cell Significance Index: -4.6400
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.3833
    Cell Significance Index: -2.6900
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.3944
    Cell Significance Index: -3.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3945
    Cell Significance Index: -3.6900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3957
    Cell Significance Index: -3.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSN3, or casein kappa, is a protein that shares structural similarities with casein, a milk protein. Its primary function is to bind and stabilize other proteins, thereby modulating their activity. This protein is predominantly expressed in cells of the immune system, including T cells, B cells, and plasma cells, which are essential for adaptive immunity. Additionally, CSN3 is also found in cells of the nervous system, such as oligodendrocyte precursor cells and cerebral cortex GABAergic interneurons, highlighting its potential role in neural function and development. **Pathways and Functions:** CSN3 is involved in various molecular functions and pathways, including: 1. **Protein binding and stabilization:** CSN3's primary function is to bind and stabilize other proteins, thereby modulating their activity. This interaction can influence protein stability, localization, and activity, ultimately affecting cellular processes. 2. **Transport of small molecules:** CSN3 is also involved in the transport of small molecules across cellular membranes, which is essential for maintaining cellular homeostasis. 3. **Lactation:** CSN3 is expressed in milk-producing cells, suggesting its involvement in lactation and milk composition. 4. **Immune system regulation:** CSN3's expression in immune cells, such as T cells and B cells, highlights its potential role in regulating immune responses and maintaining immune homeostasis. **Clinical Significance:** The study of CSN3's immunological significance has far-reaching implications for various diseases and disorders: 1. **Autoimmune disorders:** Dysregulation of CSN3's function in immune cells may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Neurological disorders:** CSN3's involvement in neural function and development suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** CSN3's expression in plasma cells and its potential role in regulating immune responses may influence cancer development and progression. 4. **Infectious diseases:** CSN3's involvement in immune system regulation and its expression in immune cells suggest its potential role in infectious diseases, such as tuberculosis and HIV. In conclusion, the CSN3 gene, or casein kappa, is a multifunctional protein that plays a crucial role in various cellular processes, including protein binding, stabilization, and transport. Its expression in diverse cell types highlights its potential involvement in immune homeostasis, neural function, and disease regulation. Further research is necessary to fully elucidate the immunological significance of CSN3 and its role in various diseases and disorders.

Genular Protein ID: 740852398

Symbol: CASK_HUMAN

Name: Kappa-casein

UniProtKB Accession Codes:

P07498 Q13575

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1296818

Title: Cloning and sequencing of human kappa-casein cDNA.

PubMed ID: 1296818

DOI: 10.3109/10425179209034024

PubMed ID: 8863730

Title: Structure of the human kappa-casein gene.

PubMed ID: 8863730

DOI: 10.1016/0378-1119(96)00351-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4018271

Title: Preparation and amino acid sequence of human kappa-casein.

PubMed ID: 4018271

DOI: 10.1016/0014-5793(85)80872-3

PubMed ID: 7460900

Title: Localisation and importance of the sugar part of human casein.

PubMed ID: 7460900

DOI: 10.1111/j.1432-1033.1980.tb04946.x

PubMed ID: 10191473

Title: Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy.

PubMed ID: 10191473

DOI: 10.1017/s0022029998003318

Sequence Information:

  • Length: 182
  • Mass: 20305
  • Checksum: 8A1609D2D5C94895
  • Sequence:
    • MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT 
NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI 
PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP 
TA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.