Details for: DNAJB8

Gene ID: 165721

Symbol: DNAJB8

Ensembl ID: ENSG00000179407

Description: DnaJ heat shock protein family (Hsp40) member B8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3955
    Cell Significance Index: 5.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2600
    Cell Significance Index: 3.7900
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.1459
    Cell Significance Index: 1.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1110
    Cell Significance Index: 1.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0929
    Cell Significance Index: 1.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0501
    Cell Significance Index: 0.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0245
    Cell Significance Index: 0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0156
    Cell Significance Index: 0.1900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0149
    Cell Significance Index: 0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0124
    Cell Significance Index: 2.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0035
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0048
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0094
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0096
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0100
    Cell Significance Index: -0.6700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0114
    Cell Significance Index: -0.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0117
    Cell Significance Index: -0.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0130
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0142
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0150
    Cell Significance Index: -0.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0150
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0154
    Cell Significance Index: -0.4900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0164
    Cell Significance Index: -0.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0176
    Cell Significance Index: -0.3500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0183
    Cell Significance Index: -0.2000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0191
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0199
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0211
    Cell Significance Index: -0.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0214
    Cell Significance Index: -0.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0215
    Cell Significance Index: -0.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0232
    Cell Significance Index: -0.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0235
    Cell Significance Index: -0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0240
    Cell Significance Index: -0.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0259
    Cell Significance Index: -0.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0267
    Cell Significance Index: -0.6400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0270
    Cell Significance Index: -0.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0279
    Cell Significance Index: -0.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0282
    Cell Significance Index: -0.4100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0296
    Cell Significance Index: -0.3200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0301
    Cell Significance Index: -0.5200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0315
    Cell Significance Index: -0.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0321
    Cell Significance Index: -0.4400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0323
    Cell Significance Index: -0.3900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0323
    Cell Significance Index: -0.3800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0338
    Cell Significance Index: -0.3700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0344
    Cell Significance Index: -0.3700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0351
    Cell Significance Index: -0.2600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0352
    Cell Significance Index: -0.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0353
    Cell Significance Index: -0.4900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0364
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0366
    Cell Significance Index: -0.4500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0369
    Cell Significance Index: -0.3300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0370
    Cell Significance Index: -0.3900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0371
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0374
    Cell Significance Index: -0.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0375
    Cell Significance Index: -0.4500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0390
    Cell Significance Index: -0.3300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0395
    Cell Significance Index: -0.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0403
    Cell Significance Index: -0.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0407
    Cell Significance Index: -0.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0407
    Cell Significance Index: -0.2600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0408
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0411
    Cell Significance Index: -0.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0414
    Cell Significance Index: -0.5500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0417
    Cell Significance Index: -0.4700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0421
    Cell Significance Index: -0.5500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0425
    Cell Significance Index: -0.5500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0428
    Cell Significance Index: -0.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0433
    Cell Significance Index: -0.5400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0434
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0436
    Cell Significance Index: -0.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0440
    Cell Significance Index: -0.5200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0441
    Cell Significance Index: -0.5300
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0445
    Cell Significance Index: -0.4500
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0458
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0466
    Cell Significance Index: -0.5700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0466
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0470
    Cell Significance Index: -0.5100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0471
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAJB8 is a small heat shock protein that belongs to the Hsp40 family, characterized by its ability to interact with Hsp70, a major molecular chaperone. This interaction enables DNAJB8 to modulate the activity of Hsp70, thereby influencing protein folding and degradation. DNAJB8 is predominantly expressed in various cell types, including progenitor cells, oligodendrocyte precursor cells, microglial cells, and neoplastic cells, suggesting a broad role in cellular homeostasis. **Pathways and Functions:** DNAJB8 is involved in several key signaling pathways, including: 1. **Chaperone-mediated protein folding**: DNAJB8 interacts with Hsp70 to facilitate the proper folding of proteins, preventing the aggregation of misfolded proteins that can lead to cellular stress. 2. **Negative regulation of inclusion body assembly**: DNAJB8 inhibits the formation of inclusion bodies, which are aggregates of misfolded proteins that can be toxic to cells. 3. **Hsp70 protein binding**: DNAJB8 binds to Hsp70, modulating its activity and influencing protein folding and degradation. 4. **Unfolded protein binding**: DNAJB8 interacts with unfolded proteins, facilitating their proper folding and preventing the formation of inclusion bodies. **Clinical Significance:** The dysregulation of DNAJB8 has been implicated in various diseases, including neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Overexpression of DNAJB8 has been observed in several types of cancer, including breast cancer, lung cancer, and colon cancer, suggesting its potential role as a tumor suppressor. Furthermore, DNAJB8 has been shown to play a critical role in the pathogenesis of inclusion body myositis, a neurodegenerative disorder characterized by muscle wasting and weakness. In conclusion, DNAJB8 is a critical molecular chaperone that plays a pivotal role in maintaining protein homeostasis within cells. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the development of therapeutic strategies to target its activity.

Genular Protein ID: 195632837

Symbol: DNJB8_HUMAN

Name: DnaJ homolog subfamily B member 8

UniProtKB Accession Codes:

Q8NHS0 B3KWV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20159555

Title: A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.

PubMed ID: 20159555

DOI: 10.1016/j.molcel.2010.01.001

Sequence Information:

  • Length: 232
  • Mass: 25686
  • Checksum: 058B180995B772F6
  • Sequence:
    • MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK 
KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN 
SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK 
SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.