Details for: DMRT1

Gene ID: 1761

Symbol: DMRT1

Ensembl ID: ENSG00000137090

Description: doublesex and mab-3 related transcription factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.16
    Marker Score: 1492
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.43
    Marker Score: 1792
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2696.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.37
    Marker Score: 1525
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.19
    Marker Score: 2227
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.12
    Marker Score: 2273
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16701
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.03
    Marker Score: 297
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.97
    Marker Score: 1398
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6425
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.96
    Marker Score: 953
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.88
    Marker Score: 5197
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.81
    Marker Score: 428
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.75
    Marker Score: 801.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.73
    Marker Score: 807.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 431
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.68
    Marker Score: 1405
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.67
    Marker Score: 302
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 276
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 348
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 448
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 138
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 938
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 176
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 364
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.33
    Marker Score: 544
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 318
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 168
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.25
    Marker Score: 64
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 167
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.23
    Marker Score: 2308.5
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 366
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 84
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 117
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2
    Marker Score: 129
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 100.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 156
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.18
    Marker Score: 309
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.18
    Marker Score: 313
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.17
    Marker Score: 237
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 63
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 141
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.14
    Marker Score: 156
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 130

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Other Information

**Key characteristics** * DMRT1 is a member of the doublesex and mab-3 (DMRT) family of transcription factors. * It is highly expressed in germ cells and is essential for their survival and differentiation. * DMRT1 is a key regulator of male germ cell migration, proliferation, and differentiation. * It is also involved in the regulation of spermatogenesis, the process by which male gametes are produced. **Pathways and functions** * DMRT1 is involved in cell morphogenesis by promoting the expression of genes involved in cell migration and proliferation. * It is also involved in chromatin binding and DNA-binding transcription factor activity, which are essential for the proper regulation of gene expression. * DMRT1 plays a crucial role in the development and maintenance of male germ cells by regulating the expression of genes involved in germ cell migration, differentiation, and survival. * It is also involved in the regulation of spermatogenesis, the process by which male gametes are produced. **Clinical significance** * Mutations in the DMRT1 gene have been linked to male infertility and reproductive failure. * Targeting DMRT1 has emerged as a potential therapeutic strategy for male infertility. **Additional information** * The human DMRT1 gene is located on chromosome 18q21.1. * It is a highly conserved protein with a similar sequence in other mammals. * DMRT1 is a well-characterized transcription factor that plays a critical role in male germ cell development and spermatogenesis.

Genular Protein ID: 1813019202

Symbol: DMRT1_HUMAN

Name: Doublesex- and mab-3-related transcription factor 1

UniProtKB Accession Codes:

Q9Y5R6 B2R913 Q6T1H8 Q6T1H9 Q8IW77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10332030

Title: A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.

PubMed ID: 10332030

DOI: 10.1093/hmg/8.6.989

PubMed ID: 10857744

Title: A new submicroscopic deletion that refines the 9p region for sex reversal.

PubMed ID: 10857744

DOI: 10.1006/geno.2000.6160

PubMed ID: 16617334

Title: Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis.

PubMed ID: 16617334

DOI: 10.1038/sj.cr.7310050

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9718346

Title: A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779.

PubMed ID: 9718346

DOI: 10.1086/302016

PubMed ID: 9490411

Title: Evidence for evolutionary conservation of sex-determining genes.

PubMed ID: 9490411

DOI: 10.1038/35618

PubMed ID: 20543847

Title: Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.

PubMed ID: 20543847

DOI: 10.1038/ng.607

PubMed ID: 21048976

Title: Identification of de novo copy number variants associated with human disorders of sexual development.

PubMed ID: 21048976

DOI: 10.1371/journal.pone.0015392

PubMed ID: 23436708

Title: Scanning of novel cancer/testis proteins by human testis proteomic analysis.

PubMed ID: 23436708

DOI: 10.1002/pmic.201200489

Sequence Information:

  • Length: 373
  • Mass: 39473
  • Checksum: 23348B2C4A4733A1
  • Sequence:
    • MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS SRGGGSGSGA 
SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC QCKKCNLIAE RQRVMAAQVA 
LRRQQAQEEE LGISHPIPLP SAAELLVKRE NNGSNPCLMT ECSGTSQPPP ASVPTTAASE 
GRMVIQDIPA VTSRGHVENT PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA 
SGEVGNPLGG SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL 
GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA VLECEPASEP 
SSFTVTPVIE EDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.