Details for: EIF4EBP2

Gene ID: 1979

Symbol: EIF4EBP2

Ensembl ID: ENSG00000148730

Description: eukaryotic translation initiation factor 4E binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.84
    Marker Score: 1967
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.7
    Marker Score: 1159
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.65
    Marker Score: 1737
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.62
    Marker Score: 3680
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.58
    Marker Score: 2332
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.52
    Marker Score: 9697
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.5
    Marker Score: 3686
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.48
    Marker Score: 7114
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.48
    Marker Score: 82746
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.44
    Marker Score: 5127.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.4
    Marker Score: 1104
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.38
    Marker Score: 318.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.38
    Marker Score: 1437
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.34
    Marker Score: 1547
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.34
    Marker Score: 2060
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.32
    Marker Score: 883
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.32
    Marker Score: 2785
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.26
    Marker Score: 2857
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.25
    Marker Score: 3122
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.21
    Marker Score: 821
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.2
    Marker Score: 683
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.19
    Marker Score: 1977
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.19
    Marker Score: 1281
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.19
    Marker Score: 5112.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.18
    Marker Score: 413
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.18
    Marker Score: 1259
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.17
    Marker Score: 3663
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.16
    Marker Score: 4836
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.15
    Marker Score: 1447
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.15
    Marker Score: 433
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.14
    Marker Score: 328
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.13
    Marker Score: 4380
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1192
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.13
    Marker Score: 4696
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 524.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.11
    Marker Score: 2801
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.1
    Marker Score: 2150
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.1
    Marker Score: 778
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.1
    Marker Score: 1057
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.1
    Marker Score: 1422
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 37999
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.1
    Marker Score: 613
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.08
    Marker Score: 4258
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.08
    Marker Score: 1019
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.08
    Marker Score: 9330
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.08
    Marker Score: 23091
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.07
    Marker Score: 672.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.06
    Marker Score: 6890
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.05
    Marker Score: 911
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.05
    Marker Score: 333
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16314.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.04
    Marker Score: 248.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.04
    Marker Score: 1253.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.04
    Marker Score: 18397
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.03
    Marker Score: 11653
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.03
    Marker Score: 511
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.03
    Marker Score: 259
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.03
    Marker Score: 26342
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.03
    Marker Score: 2755
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 697
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.01
    Marker Score: 2110
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.01
    Marker Score: 319
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.01
    Marker Score: 3173
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1
    Marker Score: 1011
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 403
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1
    Marker Score: 5254
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1
    Marker Score: 431
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1
    Marker Score: 430
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71589.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47812
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.99
    Marker Score: 912
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Marker Score: 2358
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.99
    Marker Score: 983
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2158.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30361
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Marker Score: 652
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.97
    Marker Score: 1547
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.97
    Marker Score: 395
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 365
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.97
    Marker Score: 1132
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.96
    Marker Score: 979
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.96
    Marker Score: 599
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1377
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.95
    Marker Score: 849
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.95
    Marker Score: 1529
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.95
    Marker Score: 1682.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.95
    Marker Score: 602
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.94
    Marker Score: 5726
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.94
    Marker Score: 231.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 239
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.94
    Marker Score: 1036
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.94
    Marker Score: 6971
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.94
    Marker Score: 457
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.94
    Marker Score: 232
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2374
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.93
    Marker Score: 378
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.93
    Marker Score: 212.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.93
    Marker Score: 2425
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.92
    Marker Score: 448

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Other Information

## Summary EIF4EBP2 is a key regulator of translation initiation in eukaryotic cells. It is a protein that binds to the 5' cap of mRNA and recruits the 4E-BP1 complex to the start codon, thereby promoting translation initiation. ## Key characteristics * EIF4EBP2 is a protein of the EIF4E family of proteins, which are involved in the initiation of protein synthesis. * It is a highly conserved protein with a predicted molecular weight of 135 kDa. * It is found in a variety of cell types, including skeletal muscle satellite stem cells, squamous epithelial cells, conjunctival epithelial cells, and enterocytes. ## Pathways and functions * EIF4EBP2 is involved in a variety of cellular processes, including translation initiation, cell cycle regulation, and apoptosis. * It is a key regulator of muscle development and function. * It is also involved in the regulation of insulin receptor signaling, the formation of the nuclear pore complex, and the regulation of synaptic plasticity. ## Clinical significance * Mutations in EIF4EBP2 have been linked to several human diseases, including cancer, neurodegenerative disorders, and metabolic syndrome. * Targeting EIF4EBP2 has been investigated as a potential therapeutic strategy for these diseases. ## Conclusion EIF4EBP2 is a critical regulator of translation initiation in eukaryotic cells. Its mutations have a significant impact on the development and function of tissues and organs.

Genular Protein ID: 2797853288

Symbol: 4EBP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13542

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7935836

Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

PubMed ID: 7935836

DOI: 10.1038/371762a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24207126

Title: Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.

PubMed ID: 24207126

DOI: 10.1016/j.str.2013.08.030

PubMed ID: 30765518

Title: Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

PubMed ID: 30765518

DOI: 10.1073/pnas.1814385116

PubMed ID: 21661078

Title: Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.

PubMed ID: 21661078

DOI: 10.1002/psc.1384

PubMed ID: 25533957

Title: Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

PubMed ID: 25533957

DOI: 10.1038/nature13999

Sequence Information:

  • Length: 120
  • Mass: 12939
  • Checksum: B8F109261A504193
  • Sequence:
    • MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL 
DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.