Details for: FMO1

Gene ID: 2326

Symbol: FMO1

Ensembl ID: ENSG00000010932

Description: flavin containing dimethylaniline monoxygenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.25
    Marker Score: 3472
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.6
    Marker Score: 5665
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.04
    Marker Score: 1091
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2265
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 378
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1293
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.76
    Marker Score: 2485
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.72
    Marker Score: 4692
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.72
    Marker Score: 354
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.71
    Marker Score: 477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2962
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1433
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1196
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8481.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.52
    Marker Score: 565
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.51
    Marker Score: 735.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.45
    Marker Score: 947
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2638
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 402
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.43
    Marker Score: 1792
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.4
    Marker Score: 551
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 234
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.38
    Marker Score: 631
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.37
    Marker Score: 958
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.32
    Marker Score: 396
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 149
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.29
    Marker Score: 2918
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.27
    Marker Score: 195
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 256
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.25
    Marker Score: 8374.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.24
    Marker Score: 1148
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.22
    Marker Score: 72
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.21
    Marker Score: 47
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 138
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.21
    Marker Score: 396
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 254
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.19
    Marker Score: 328
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.18
    Marker Score: 565
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.17
    Marker Score: 108
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.17
    Marker Score: 259
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.16
    Marker Score: 624
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 254
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 98
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 118
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.13
    Marker Score: 216
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.13
    Marker Score: 968
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.13
    Marker Score: 143
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 376
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.12
    Marker Score: 128
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.12
    Marker Score: 340

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Other Information

**Key characteristics:** - FMO1 is a protein with a molecular weight of approximately 120 kDa. - It is a flavoprotein, meaning that it contains a flavin domain. - FMO1 is a member of the FMO family of enzymes, which are involved in the metabolism of flavin. **Pathways and functions:** FMO1 is involved in a variety of pathways, including: - Biological oxidations - Degradation of cysteine and homocysteine - Flavin adenine dinucleotide binding - Fmo oxidises nucleophiles - Hypotaurine dehydrogenase activity - Metabolism - Metabolism of amino acids and derivatives - Monooxygenase activity - N,n-dimethylaniline monooxygenase activity - Nadp binding - Organic acid metabolic process - Phase i - functionalization of compounds - Protein binding - Response to lipopolysaccharide - Sulfur amino acid catabolic process - Sulfur amino acid metabolism - Toxin metabolic process - Trimethylamine monooxygenase activity - Xenobiotic metabolic process **Clinical significance:** Mutations in the FMO1 gene have been linked to several human diseases, including colorectal cancer, liver disease, and heart disease. These diseases are caused by mutations in genes that are involved in the metabolism of flavin. FMO1 is a potential target for the treatment of these diseases.

Genular Protein ID: 3065899682

Symbol: FMO1_HUMAN

Name: Dimethylaniline oxidase 1

UniProtKB Accession Codes:

Q01740 A8K248 B7Z3P4 Q5QPT2 Q9UJC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 34 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 4 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1712018

Title: Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).

PubMed ID: 1712018

DOI: 10.1016/s0021-9258(18)98908-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32156684

Title: Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.

PubMed ID: 32156684

DOI: 10.1124/dmd.119.089995

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

Sequence Information:

  • Length: 532
  • Mass: 60311
  • Checksum: 627B855F38C2EB6D
  • Sequence:
    • MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG RASLYKSVVS 
NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL LKHIQFKTKV CSVTKCSDSA 
VSGQWEVVTM HEEKQESAIF DAVMVCTGFL TNPYLPLDSF PGINAFKGQY FHSRQYKHPD 
IFKDKRVLVI GMGNSGTDIA VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ 
NMLRNSLPTP IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR 
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH 
LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP PPSVMIEEIN ARKENKPSWF 
GLCYCKALQS DYITYIDELL TYINAKPNLF SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK 
WEGARNAIMT QWDRTFKVIK ARVVQESPSP FESFLKVFSF LALLVAIFLI FL

Genular Protein ID: 1884076618

Symbol: B2RCG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCG5

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 28 DNASU 1 EC 4 EMBL 2 GO 6 Gene3D 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 8 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 532
  • Mass: 60310
  • Checksum: B354AA3D3A6F26A6
  • Sequence:
    • MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG RASLYKSVVS 
NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL LKHIQFKTKV CSVTKCSDSA 
VSGQWEVVTM HEEKQESAIF NAVMVCTGFL TNPYLPLDSF PGINAFKGQY FHSRQYKHPD 
IFKDKRVLVI GMGNSGTDIA VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ 
NMLRNSLPTP IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR 
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH 
LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP PPSVMIEEIN ARKENKPSWF 
GLCYCKALQS DYITYIDELL TYINAKPNLF SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK 
WEGARNAIMT QWDRTFKVIK ARVVQESPSP FESFLKVFSF LALLVAIFLI FL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.