Details for: TAS2R41

Gene ID: 259287

Symbol: TAS2R41

Ensembl ID: ENSG00000221855

Description: taste 2 receptor member 41

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5734
    Cell Significance Index: 13.8900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3799
    Cell Significance Index: 4.9600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.3355
    Cell Significance Index: 4.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2941
    Cell Significance Index: 3.8600
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2556
    Cell Significance Index: 3.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1539
    Cell Significance Index: 2.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1278
    Cell Significance Index: 2.0700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0876
    Cell Significance Index: 1.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0809
    Cell Significance Index: 0.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0561
    Cell Significance Index: 0.7300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0466
    Cell Significance Index: 0.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0465
    Cell Significance Index: 0.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0404
    Cell Significance Index: 0.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0250
    Cell Significance Index: 0.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0199
    Cell Significance Index: 0.2400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0092
    Cell Significance Index: 0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0040
    Cell Significance Index: 0.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0053
    Cell Significance Index: -0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0055
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0169
    Cell Significance Index: -0.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0173
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0192
    Cell Significance Index: -0.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0206
    Cell Significance Index: -0.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0227
    Cell Significance Index: -0.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0261
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0267
    Cell Significance Index: -0.2700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0270
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0270
    Cell Significance Index: -0.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0279
    Cell Significance Index: -0.2800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0280
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0298
    Cell Significance Index: -0.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0298
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0299
    Cell Significance Index: -0.6000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0309
    Cell Significance Index: -0.3300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0314
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0319
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0341
    Cell Significance Index: -0.6700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0350
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0357
    Cell Significance Index: -0.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0367
    Cell Significance Index: -0.5900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0370
    Cell Significance Index: -0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0371
    Cell Significance Index: -0.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0378
    Cell Significance Index: -0.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0382
    Cell Significance Index: -0.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0386
    Cell Significance Index: -0.4200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0389
    Cell Significance Index: -0.4400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0390
    Cell Significance Index: -0.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0394
    Cell Significance Index: -0.5600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0402
    Cell Significance Index: -0.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0406
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0415
    Cell Significance Index: -0.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0416
    Cell Significance Index: -0.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0443
    Cell Significance Index: -0.5500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0445
    Cell Significance Index: -0.5300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0451
    Cell Significance Index: -0.5200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0464
    Cell Significance Index: -0.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0464
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0491
    Cell Significance Index: -0.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0509
    Cell Significance Index: -0.5200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0531
    Cell Significance Index: -0.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0550
    Cell Significance Index: -0.6200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0565
    Cell Significance Index: -0.6000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0580
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0588
    Cell Significance Index: -0.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0604
    Cell Significance Index: -0.5900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0605
    Cell Significance Index: -0.5500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0613
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0614
    Cell Significance Index: -0.5900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0615
    Cell Significance Index: -0.6600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0617
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0617
    Cell Significance Index: -0.6400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0654
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0654
    Cell Significance Index: -0.6900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0655
    Cell Significance Index: -0.6600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0657
    Cell Significance Index: -0.5600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0672
    Cell Significance Index: -0.5800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0679
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0696
    Cell Significance Index: -0.6600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0696
    Cell Significance Index: -0.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0700
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0700
    Cell Significance Index: -0.8600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0714
    Cell Significance Index: -0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0714
    Cell Significance Index: -1.2000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0739
    Cell Significance Index: -0.7600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0752
    Cell Significance Index: -0.4800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0757
    Cell Significance Index: -0.7600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0760
    Cell Significance Index: -0.6700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0764
    Cell Significance Index: -0.5300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0803
    Cell Significance Index: -0.4300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0843
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAS2R41 is a G protein-coupled receptor (GPCR) that belongs to the T2R family, which is a subgroup of taste receptors. These receptors are responsible for detecting bitter, sweet, and umami taste compounds. TAS2R41 is specifically involved in the detection of bitter taste, and its expression is found in various cell types, including glutamatergic neurons, progenitor cells, and blood vessel endothelial cells. The gene is highly expressed in the oral cavity, where it plays a crucial role in the sensory perception of bitter taste. **Pathways and Functions:** The TAS2R41 gene is activated by bitter taste compounds, such as quinine and PROP (6-n-propylthiouracil), which bind to the receptor and trigger a signaling cascade. This cascade involves the activation of G proteins, which in turn activate downstream signaling pathways, including G alpha (i) signaling events and GPCR downstream signaling. The activation of these pathways leads to the activation of various cellular responses, including changes in ion channel activity and the production of signaling molecules. The TAS2R41 gene plays a critical role in maintaining the health of the oral cavity and preventing the ingestion of toxic substances. By detecting bitter taste compounds, the receptor helps to prevent the intake of substances that are toxic to the body. Additionally, TAS2R41 may also play a role in the regulation of appetite and food selection, as bitter taste compounds can signal the presence of toxic substances. **Clinical Significance:** Dysfunction of the TAS2R41 gene has been implicated in various diseases, including diabetes, obesity, and metabolic disorders. For example, individuals with diabetes may have impaired TAS2R41 function, leading to an increased risk of developing metabolic disorders. Additionally, genetic variations in the TAS2R41 gene have been associated with an increased risk of developing certain types of cancer, such as lung and breast cancer. Furthermore, TAS2R41 may also play a role in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. The receptor's ability to detect bitter taste compounds may also be impaired in individuals with these disorders, leading to changes in taste perception and cognitive function. In conclusion, the TAS2R41 gene is a critical component of the human taste system, responsible for detecting bitter taste compounds. Its dysfunction has been implicated in various diseases, including diabetes, obesity, and metabolic disorders. Further research is needed to fully understand the role of TAS2R41 in human health and disease, but it is clear that this gene plays a vital role in maintaining overall health and preventing the ingestion of toxic substances. **References:** * [Insert references here] Note: The references section is not provided as it was not mentioned in the prompt.

Genular Protein ID: 39719745

Symbol: T2R41_HUMAN

Name: Taste receptor type 2 member 41

UniProtKB Accession Codes:

P59536 P59550 Q495I2 Q50KJ5 Q50KJ6 Q50KJ7 Q645W7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DrugCentral 1 EMBL 9 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12584440

Title: Identification and characterization of human taste receptor genes belonging to the TAS2R family.

PubMed ID: 12584440

DOI: 10.1159/000068546

PubMed ID: 12379855

Title: The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.

PubMed ID: 12379855

DOI: 10.1038/ng1014

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15744053

Title: Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

PubMed ID: 15744053

DOI: 10.1534/genetics.104.037523

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 307
  • Mass: 35896
  • Checksum: 7A33E3ED3E44E563
  • Sequence:
    • MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS LGASRFCLQL 
VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC SWLSVLFCVK IANITHSTFL 
WLKWRFPGWV PWLLLGSVLI SFIITLLFFW VNYPVYQEFL IRKFSGNMTY KWNTRIETYY 
FPSLKLVIWS IPFSVFLVSI MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL 
ILYALSFLSL IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL 
ARGFWVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.