OPN1MW | ENSG00000268221 | NCBI 2652

Details for: OPN1MW

Gene ID: 2652

Symbol: OPN1MW

Ensembl ID: ENSG00000268221

Description: opsin 1, medium wave sensitive

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Defective visual phototransduction due to opn1mw loss of function
(R-HSA-9918436)
Disease
(R-HSA-1643685)
Diseases associated with visual transduction
(R-HSA-2474795)
Diseases of the neuronal system
(R-HSA-9675143)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Opsins
(R-HSA-419771)
Retinoid cycle disease events
(R-HSA-2453864)
Sensory perception
(R-HSA-9709957)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
The retinoid cycle in cones (daylight vision)
(R-HSA-2187335)
Visual phototransduction
(R-HSA-2187338)
Cellular response to light stimulus
(GO:0071482)
Detection of visible light
(GO:0009584)
G protein-coupled photoreceptor activity
(GO:0008020)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Photoreceptor activity
(GO:0009881)
Photoreceptor disc membrane
(GO:0097381)
Photoreceptor outer segment
(GO:0001750)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Positive regulation of cytokinesis
(GO:0032467)
Visual perception
(GO:0007601)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3211
Cell Significance Index: 20.2400
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0210
Cell Significance Index: 0.2500
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.0080
Cell Significance Index: 0.1000
Cell Name: retinal astrocyte (CL4033015)
Fold Change: 0.0018
Cell Significance Index: 0.0200
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.0006
Cell Significance Index: 0.0100
Cell Name: neural cell (CL0002319)
Fold Change: 0.0005
Cell Significance Index: 0.0100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0011
Cell Significance Index: -0.7800
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0013
Cell Significance Index: -0.0300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0025
Cell Significance Index: -0.5100
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0031
Cell Significance Index: -0.0300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0044
Cell Significance Index: -0.7500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0052
Cell Significance Index: -0.0400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0065
Cell Significance Index: -0.7500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0119
Cell Significance Index: -0.6700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0143
Cell Significance Index: -0.7500
Cell Name: neuron (CL0000540)
Fold Change: -0.0163
Cell Significance Index: -0.1500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0185
Cell Significance Index: -0.5900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0187
Cell Significance Index: -0.5000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0196
Cell Significance Index: -0.4900
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0202
Cell Significance Index: -0.3400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0241
Cell Significance Index: -0.5200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0261
Cell Significance Index: -0.5600
Cell Name: pericyte (CL0000669)
Fold Change: -0.0275
Cell Significance Index: -0.3300
Cell Name: adipocyte (CL0000136)
Fold Change: -0.0280
Cell Significance Index: -0.3700
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0281
Cell Significance Index: -0.3600
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0290
Cell Significance Index: -0.5700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0296
Cell Significance Index: -0.4100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0300
Cell Significance Index: -0.4300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0309
Cell Significance Index: -0.6200
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.0310
Cell Significance Index: -0.3600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0312
Cell Significance Index: -0.3800
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0312
Cell Significance Index: -0.3400
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.0318
Cell Significance Index: -0.3200
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.0320
Cell Significance Index: -0.3400
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0322
Cell Significance Index: -0.4200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0327
Cell Significance Index: -0.4100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0331
Cell Significance Index: -0.6600
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0344
Cell Significance Index: -0.4500
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.0349
Cell Significance Index: -0.3000
Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.0367
Cell Significance Index: -0.4600
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.0368
Cell Significance Index: -0.3600
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0373
Cell Significance Index: -0.6500
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.0377
Cell Significance Index: -0.4100
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.0379
Cell Significance Index: -0.4200
Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.0393
Cell Significance Index: -0.4500
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0411
Cell Significance Index: -0.5200
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0412
Cell Significance Index: -0.5200
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0431
Cell Significance Index: -0.5300
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0437
Cell Significance Index: -0.5300
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0443
Cell Significance Index: -0.4800
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0447
Cell Significance Index: -0.4200
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.0454
Cell Significance Index: -0.4000
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0460
Cell Significance Index: -0.5200
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.0474
Cell Significance Index: -0.4200
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0475
Cell Significance Index: -0.6500
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.0475
Cell Significance Index: -0.4300
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.0482
Cell Significance Index: -0.4200
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.0491
Cell Significance Index: -0.6100
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.0493
Cell Significance Index: -0.5300
Cell Name: macrophage (CL0000235)
Fold Change: -0.0509
Cell Significance Index: -0.5200
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0509
Cell Significance Index: -0.4200
Cell Name: mast cell (CL0000097)
Fold Change: -0.0509
Cell Significance Index: -0.6700
Cell Name: neutrophil (CL0000775)
Fold Change: -0.0512
Cell Significance Index: -0.6400
Cell Name: monocyte (CL0000576)
Fold Change: -0.0513
Cell Significance Index: -0.5900
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0515
Cell Significance Index: -0.8800
Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.0523
Cell Significance Index: -0.6500
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: -0.0526
Cell Significance Index: -0.4200
Cell Name: H1 horizontal cell (CL0004217)
Fold Change: -0.0533
Cell Significance Index: -0.6700
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0533
Cell Significance Index: -0.6700
Cell Name: diffuse bipolar 1 cell (CL4033027)
Fold Change: -0.0540
Cell Significance Index: -0.6600
Cell Name: basal cell (CL0000646)
Fold Change: -0.0544
Cell Significance Index: -0.6500
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.0550
Cell Significance Index: -0.5900
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.0551
Cell Significance Index: -0.5700
Cell Name: diffuse bipolar 2 cell (CL4033028)
Fold Change: -0.0554
Cell Significance Index: -0.6800
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0555
Cell Significance Index: -0.6500
Cell Name: S cone cell (CL0003050)
Fold Change: -0.0558
Cell Significance Index: -0.6500
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0559
Cell Significance Index: -0.6600
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0562
Cell Significance Index: -0.8500
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.0566
Cell Significance Index: -0.5000
Cell Name: H2 horizontal cell (CL0004218)
Fold Change: -0.0567
Cell Significance Index: -0.6700
Cell Name: diffuse bipolar 4 cell (CL4033031)
Fold Change: -0.0567
Cell Significance Index: -0.6900
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0568
Cell Significance Index: -0.6500
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.0573
Cell Significance Index: -0.5100
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0581
Cell Significance Index: -0.7400
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: -0.0591
Cell Significance Index: -0.6400
Cell Name: diffuse bipolar 3a cell (CL4033029)
Fold Change: -0.0598
Cell Significance Index: -0.7200
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.0612
Cell Significance Index: -0.7000
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.0613
Cell Significance Index: -0.7100
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: -0.0614
Cell Significance Index: -0.7400
Cell Name: B cell (CL0000236)
Fold Change: -0.0614
Cell Significance Index: -0.7300
Cell Name: ON parasol ganglion cell (CL4033052)
Fold Change: -0.0618
Cell Significance Index: -0.7700
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0620
Cell Significance Index: -0.5800
Cell Name: diffuse bipolar 3b cell (CL4033030)
Fold Change: -0.0622
Cell Significance Index: -0.7500
Cell Name: giant bipolar cell (CL4033035)
Fold Change: -0.0628
Cell Significance Index: -0.7400
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.0660
Cell Significance Index: -0.4100
Cell Name: OFF parasol ganglion cell (CL4033051)
Fold Change: -0.0665
Cell Significance Index: -0.8400
Cell Name: diffuse bipolar 6 cell (CL4033032)
Fold Change: -0.0669
Cell Significance Index: -0.7700
Cell Name: malignant cell (CL0001064)
Fold Change: -0.0672
Cell Significance Index: -0.3600
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.0686
Cell Significance Index: -0.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** OPN1MW is a member of the opsin family, which is a group of G-protein coupled receptors (GPCRs) responsible for detecting light in the retina. Specifically, OPN1MW is sensitive to medium wave light, which is essential for detecting blue-violet light. This gene is primarily expressed in photoreceptor cells, which are specialized cells in the retina responsible for converting light into electrical signals. The expression of OPN1MW is also found in other cell types, including smooth muscle myoblasts, goblet cells, and intestinal epithelial cells. **Pathways and Functions:** OPN1MW is involved in several signaling pathways that are crucial for visual transduction. The primary pathway is the phototransduction pathway, which involves the activation of OPN1MW by light. This activation triggers a series of downstream signaling events that ultimately lead to the generation of an electrical signal in the photoreceptor cell. The phototransduction pathway involves the activation of G-proteins, which in turn activate downstream effectors that regulate the activity of ion channels and pumps in the photoreceptor cell membrane. In addition to its role in visual transduction, OPN1MW is also involved in other signaling pathways, including the Gpcr downstream signaling pathway, Gpcr ligand binding pathway, and the G protein-coupled photoreceptor activity pathway. These pathways are involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of OPN1MW has been implicated in several diseases, including retinitis pigmentosa, a group of inherited disorders that affect the retina and lead to progressive vision loss. Mutations in the OPN1MW gene have been associated with an increased risk of developing retinitis pigmentosa, particularly in individuals with a family history of the disease. In addition to its role in retinitis pigmentosa, OPN1MW has also been implicated in other diseases, including age-related macular degeneration and diabetic retinopathy. These diseases are characterized by the degeneration of photoreceptor cells and the disruption of the phototransduction pathway, leading to vision loss. In conclusion, OPN1MW is a gene that plays a critical role in visual transduction and beyond. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining normal vision and preventing vision loss. Further research is needed to fully understand the mechanisms underlying OPN1MW and its role in disease. **Signaling by Gpcr, Signal transduction, The retinoid cycle in cones (daylight vision), Visual perception, Visual phototransduction** **Signaling by gpcr is a pathway that involves the activation of G-proteins by ligand binding to GPCRs.** **Signal transduction is the process by which a signal is transmitted from a receptor to an effector, resulting in a specific response.** **The retinoid cycle in cones (daylight vision) is a pathway that involves the conversion of 11-cis-retinal to 11-trans-retinal, which is essential for the regeneration of opsin proteins in cone photoreceptors.** **Visual perception is the process by which the brain interprets visual information from the retina.** **Visual phototransduction is the process by which light is converted into electrical signals in photoreceptor cells.**

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.