Details for: OR2T1

Gene ID: 26696

Symbol: OR2T1

Ensembl ID: ENSG00000175143

Description: olfactory receptor family 2 subfamily T member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.9756
    Cell Significance Index: 50.3400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.0694
    Cell Significance Index: 18.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.9342
    Cell Significance Index: 15.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5641
    Cell Significance Index: 7.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5479
    Cell Significance Index: 7.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4662
    Cell Significance Index: 6.1400
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.2048
    Cell Significance Index: 2.3900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1949
    Cell Significance Index: 2.0700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.1757
    Cell Significance Index: 2.0400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0413
    Cell Significance Index: 0.6000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0218
    Cell Significance Index: 0.2700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0139
    Cell Significance Index: 0.1400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0050
    Cell Significance Index: 0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0108
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0147
    Cell Significance Index: -0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0155
    Cell Significance Index: -0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0174
    Cell Significance Index: -0.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0188
    Cell Significance Index: -0.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0211
    Cell Significance Index: -0.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0236
    Cell Significance Index: -0.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0256
    Cell Significance Index: -0.5500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0299
    Cell Significance Index: -0.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0300
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0304
    Cell Significance Index: -0.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0339
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0354
    Cell Significance Index: -0.7000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0354
    Cell Significance Index: -0.4200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0369
    Cell Significance Index: -0.7400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0370
    Cell Significance Index: -0.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0389
    Cell Significance Index: -0.4900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0404
    Cell Significance Index: -0.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0405
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0411
    Cell Significance Index: -0.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0413
    Cell Significance Index: -0.4900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0430
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0431
    Cell Significance Index: -0.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0442
    Cell Significance Index: -0.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0445
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0456
    Cell Significance Index: -0.5600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0475
    Cell Significance Index: -0.5000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0478
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0500
    Cell Significance Index: -0.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0527
    Cell Significance Index: -0.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0528
    Cell Significance Index: -0.5800
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0532
    Cell Significance Index: -0.6100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0533
    Cell Significance Index: -0.5700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0534
    Cell Significance Index: -0.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0537
    Cell Significance Index: -0.6700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0540
    Cell Significance Index: -0.7200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0547
    Cell Significance Index: -0.6900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0553
    Cell Significance Index: -0.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0560
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0567
    Cell Significance Index: -0.7400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0574
    Cell Significance Index: -0.7200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0575
    Cell Significance Index: -0.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0575
    Cell Significance Index: -0.7300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0592
    Cell Significance Index: -0.7100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0593
    Cell Significance Index: -0.6700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0593
    Cell Significance Index: -0.7400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0598
    Cell Significance Index: -0.7200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0605
    Cell Significance Index: -0.6100
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0609
    Cell Significance Index: -0.7700
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0614
    Cell Significance Index: -0.7700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0615
    Cell Significance Index: -0.7500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0615
    Cell Significance Index: -0.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0625
    Cell Significance Index: -0.7500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0629
    Cell Significance Index: -0.7200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0634
    Cell Significance Index: -0.7700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0650
    Cell Significance Index: -0.6900
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0655
    Cell Significance Index: -0.7700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0658
    Cell Significance Index: -0.7100
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0660
    Cell Significance Index: -0.8300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0662
    Cell Significance Index: -0.5600
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0664
    Cell Significance Index: -0.8200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0668
    Cell Significance Index: -0.8300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0671
    Cell Significance Index: -0.7400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0680
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0705
    Cell Significance Index: -0.5100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0724
    Cell Significance Index: -0.8300
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0732
    Cell Significance Index: -0.7400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0772
    Cell Significance Index: -0.8300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0840
    Cell Significance Index: -0.7400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0844
    Cell Significance Index: -0.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0860
    Cell Significance Index: -0.8200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0927
    Cell Significance Index: -0.7700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0947
    Cell Significance Index: -0.6200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0958
    Cell Significance Index: -0.7400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0971
    Cell Significance Index: -0.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1037
    Cell Significance Index: -0.8000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1063
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family**: OR2T1 belongs to the olfactory receptor family, which is a subset of G protein-coupled receptors (GPCRs) that are responsible for detecting odorant molecules in the air we breathe. 2. **Expression in Multiple Cell Types**: OR2T1 is expressed in a wide range of cell types, including erythrocytes, goblet cells, and intestinal epithelial cells, suggesting its involvement in various physiological processes beyond olfaction. 3. **G Protein-Coupled Receptor Activity**: OR2T1 is a GPCR, which means it can activate G proteins to transmit signals within the cell. 4. **Sensory Perception**: OR2T1 is involved in the detection of chemical stimuli, which is essential for the sense of smell. **Pathways and Functions:** 1. **Detection of Chemical Stimulus**: OR2T1 plays a critical role in detecting odorant molecules, which are essential for the sense of smell. 2. **Olfactory Signaling Pathway**: OR2T1 is part of the olfactory signaling pathway, which involves the activation of G proteins and the transmission of signals to the brain. 3. **G Protein-Coupled Receptor Signaling Pathway**: OR2T1 is also involved in the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular processes. 4. **Expression and Translocation of Olfactory Receptors**: OR2T1 is involved in the expression and translocation of olfactory receptors, which is essential for the proper functioning of the olfactory system. **Clinical Significance:** 1. **Olfactory Disorders**: OR2T1 has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Cancer Research**: OR2T1 has been found to be overexpressed in certain types of cancer, including colon cancer, suggesting its potential role in cancer development and progression. 3. **Neurological Disorders**: OR2T1 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in neurodegenerative diseases. 4. **Personalized Medicine**: OR2T1 has the potential to be used as a biomarker for personalized medicine, allowing for the development of targeted therapies for individuals with specific olfactory or neurological disorders. In conclusion, the OR2T1 gene is a complex and multifunctional gene that plays a critical role in the detection of chemical stimuli, olfactory signaling, and various physiological processes. Its clinical significance extends beyond the olfactory system, with implications for cancer research, neurological disorders, and personalized medicine. Further research is needed to fully elucidate the functions and potential applications of the OR2T1 gene.

Genular Protein ID: 4107019252

Symbol: OR2T1_HUMAN

Name: Olfactory receptor 2T1

UniProtKB Accession Codes:

O43869 Q6IEZ9

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 369
  • Mass: 41996
  • Checksum: 9D8E52A0312BEC3B
  • Sequence:
    • MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG SMEEYNTSST 
DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ TDLRLHTPMY FLLSHLSLID 
MMYISTIVPK MLVNYLLDQR TISFVGCTAQ HFLYLTLVGA EFFLLGLMAY DRYVAICNPL 
RYPVLMSRRV CWMIIAGSWF GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA 
DTALYETVMY VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL 
FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA LKRALGRFKG 
PQRVSGGVF

Genular Protein ID: 1864213863

Symbol: A0A126GWK9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GWK9

Database IDs:

ARBA 6 Antibodypedia 1 CDD 1 CTD 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 318
  • Mass: 35908
  • Checksum: C25741DD8CCC46F6
  • Sequence:
    • MEEYNTSSTD FTFMGLFNRK ETSGLIFAII SIIFFTALMA NGVMIFLIQT DLRLHTPMYF 
LLSHLSLIDM MYISTIVPKM LVNYLLDQRT ISFVGCTAQH FLYLTLVGAE FFLLGLMAYD 
RYVAICNPLR YPVLMSRRVC WMIIAGSWFG GSLDGFLLTP ITMSFPFCNS REINHFFCEA 
PAVLKLACAD TALYETVMYV CCVLMLLIPF SVVLASYARI LTTVQCMSSV EGRKKAFATC 
SSHMTVVSLF YGAAMYTYML PHSYHKPAQD KVLSVFYTIL TPMLNPLIYS LRNKDVTGAL 
KRALGRFKGP QRVSGGVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.