Details for: SNORD63

Gene ID: 26785

Symbol: SNORD63

Ensembl ID: ENSG00000206989

Description: small nucleolar RNA, C/D box 63

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.9691
    Cell Significance Index: -4.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.5038
    Cell Significance Index: -4.3000
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2664
    Cell Significance Index: 3.1700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1977
    Cell Significance Index: 2.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1796
    Cell Significance Index: 2.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1770
    Cell Significance Index: 8.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0944
    Cell Significance Index: 2.7200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0734
    Cell Significance Index: 0.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0461
    Cell Significance Index: 2.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0014
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0176
    Cell Significance Index: -5.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0238
    Cell Significance Index: -3.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0473
    Cell Significance Index: -2.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0487
    Cell Significance Index: -2.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0620
    Cell Significance Index: -0.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0632
    Cell Significance Index: -1.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0697
    Cell Significance Index: -3.6300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0998
    Cell Significance Index: -1.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1093
    Cell Significance Index: -6.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1361
    Cell Significance Index: -4.0100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1384
    Cell Significance Index: -1.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1561
    Cell Significance Index: -2.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1661
    Cell Significance Index: -1.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1789
    Cell Significance Index: -5.7300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1943
    Cell Significance Index: -1.7900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1981
    Cell Significance Index: -2.5600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2055
    Cell Significance Index: -2.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2445
    Cell Significance Index: -3.4800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2535
    Cell Significance Index: -3.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2617
    Cell Significance Index: -5.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2671
    Cell Significance Index: -3.4400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2727
    Cell Significance Index: -3.5600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2847
    Cell Significance Index: -3.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2863
    Cell Significance Index: -5.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2907
    Cell Significance Index: -4.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2974
    Cell Significance Index: -3.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3127
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3128
    Cell Significance Index: -3.3000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3321
    Cell Significance Index: -3.6500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3351
    Cell Significance Index: -4.4100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3407
    Cell Significance Index: -3.8700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3491
    Cell Significance Index: -4.1500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3502
    Cell Significance Index: -4.0300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3590
    Cell Significance Index: -4.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3590
    Cell Significance Index: -5.3800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3604
    Cell Significance Index: -3.9900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3651
    Cell Significance Index: -3.0200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3664
    Cell Significance Index: -3.8300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3668
    Cell Significance Index: -4.4300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3719
    Cell Significance Index: -4.1000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3755
    Cell Significance Index: -4.5700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3770
    Cell Significance Index: -4.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3791
    Cell Significance Index: -4.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3809
    Cell Significance Index: -5.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3810
    Cell Significance Index: -3.8900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3829
    Cell Significance Index: -3.9100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3840
    Cell Significance Index: -4.7200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.3921
    Cell Significance Index: -4.3900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.3969
    Cell Significance Index: -4.1500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4029
    Cell Significance Index: -4.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4049
    Cell Significance Index: -5.1100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4061
    Cell Significance Index: -5.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4089
    Cell Significance Index: -5.6200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4099
    Cell Significance Index: -5.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4127
    Cell Significance Index: -7.0100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4172
    Cell Significance Index: -5.2400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4222
    Cell Significance Index: -4.4500
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.4268
    Cell Significance Index: -4.3600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4307
    Cell Significance Index: -4.6700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4312
    Cell Significance Index: -5.0700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4315
    Cell Significance Index: -4.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4342
    Cell Significance Index: -4.7300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4348
    Cell Significance Index: -4.9000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4351
    Cell Significance Index: -4.6200
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.4353
    Cell Significance Index: -4.3200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4379
    Cell Significance Index: -5.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4418
    Cell Significance Index: -4.5800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.4441
    Cell Significance Index: -4.3600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4453
    Cell Significance Index: -4.2600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4467
    Cell Significance Index: -5.4400
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.4487
    Cell Significance Index: -4.2600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4502
    Cell Significance Index: -4.4100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4525
    Cell Significance Index: -4.2400
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.4575
    Cell Significance Index: -3.9700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4622
    Cell Significance Index: -5.2900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4675
    Cell Significance Index: -6.0100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4688
    Cell Significance Index: -4.1300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4694
    Cell Significance Index: -4.9200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4703
    Cell Significance Index: -4.3500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.4710
    Cell Significance Index: -5.3800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4713
    Cell Significance Index: -5.2200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4747
    Cell Significance Index: -4.4200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4759
    Cell Significance Index: -3.8600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4800
    Cell Significance Index: -4.8100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4805
    Cell Significance Index: -4.3300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4813
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4815
    Cell Significance Index: -4.5200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.4844
    Cell Significance Index: -4.4200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4887
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD63 is a member of the snoRNA family, which is involved in various aspects of RNA processing, including ribosome biogenesis, spliceosome assembly, and modification of small RNAs. The C/D box motif present in SNORD63 is a hallmark of snoRNAs, which are known to interact with proteins involved in RNA modification and processing. The expression of SNORD63 is widespread, with significant levels detected in cells of the cardiovascular system, immune system, and nervous system, among others. **Pathways and Functions:** SNORD63 is thought to play a role in regulating RNA processing pathways, including: 1. **Ribosome biogenesis**: SNORD63 may interact with proteins involved in ribosome assembly, ensuring proper ribosome function and translation efficiency. 2. **Spliceosome assembly**: SNORD63 could influence the assembly of the spliceosome, a complex involved in pre-mRNA splicing, thereby regulating gene expression. 3. **RNA modification**: SNORD63 may interact with enzymes involved in RNA modification, such as pseudouridylation and 2'-O-methylation, which are crucial for RNA stability and function. **Clinical Significance:** The expression of SNORD63 in various cell types suggests that this snoRNA may play a role in maintaining tissue homeostasis and regulating cellular responses to stress. Dysregulation of SNORD63 expression has been implicated in several diseases, including: 1. **Cardiovascular disease**: SNORD63 expression is altered in cardiac cells in response to stress, suggesting a potential role in the pathogenesis of cardiovascular disease. 2. **Immune system disorders**: SNORD63 expression is modulated in immune cells, implying a role in immune system function and potential involvement in autoimmune diseases. 3. **Neurological disorders**: SNORD63 expression is altered in neurons and glial cells, suggesting a potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SNORD63 is a small nucleolar RNA with significant implications in human health and disease. Further research is needed to elucidate the precise mechanisms by which SNORD63 regulates RNA processing pathways and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.