Details for: IL36A

Gene ID: 27179

Symbol: IL36A

Ensembl ID: ENSG00000136694

Description: interleukin 36 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3086
    Cell Significance Index: 3.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0997
    Cell Significance Index: 3.6600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0841
    Cell Significance Index: 1.0600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0505
    Cell Significance Index: 0.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0301
    Cell Significance Index: 0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0260
    Cell Significance Index: 0.6500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.0247
    Cell Significance Index: 0.1700
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0137
    Cell Significance Index: 0.1400
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0087
    Cell Significance Index: -1.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0093
    Cell Significance Index: -0.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0123
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0132
    Cell Significance Index: -0.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0164
    Cell Significance Index: -0.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0167
    Cell Significance Index: -0.8700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0271
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0314
    Cell Significance Index: -0.8000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0321
    Cell Significance Index: -0.3900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0442
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0475
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0481
    Cell Significance Index: -0.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0486
    Cell Significance Index: -0.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0509
    Cell Significance Index: -0.9400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0510
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0515
    Cell Significance Index: -1.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0525
    Cell Significance Index: -1.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0553
    Cell Significance Index: -1.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0560
    Cell Significance Index: -1.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0576
    Cell Significance Index: -1.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0602
    Cell Significance Index: -0.8000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0653
    Cell Significance Index: -1.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0674
    Cell Significance Index: -0.8800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0694
    Cell Significance Index: -0.3700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0704
    Cell Significance Index: -0.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0712
    Cell Significance Index: -1.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0730
    Cell Significance Index: -0.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0759
    Cell Significance Index: -1.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0783
    Cell Significance Index: -1.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0786
    Cell Significance Index: -0.8700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0786
    Cell Significance Index: -0.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0786
    Cell Significance Index: -1.6400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0793
    Cell Significance Index: -0.8700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0808
    Cell Significance Index: -0.9300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0817
    Cell Significance Index: -1.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0833
    Cell Significance Index: -1.6400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0840
    Cell Significance Index: -0.8700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0847
    Cell Significance Index: -1.0700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0851
    Cell Significance Index: -0.8700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0873
    Cell Significance Index: -0.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0881
    Cell Significance Index: -1.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0884
    Cell Significance Index: -0.9400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0887
    Cell Significance Index: -0.9400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0893
    Cell Significance Index: -0.9400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0900
    Cell Significance Index: -1.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0900
    Cell Significance Index: -1.8000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0916
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0930
    Cell Significance Index: -0.9400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0933
    Cell Significance Index: -0.9400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0942
    Cell Significance Index: -0.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0943
    Cell Significance Index: -1.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0956
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0957
    Cell Significance Index: -0.9200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0958
    Cell Significance Index: -0.8800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0978
    Cell Significance Index: -0.8600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0987
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0991
    Cell Significance Index: -0.9400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1010
    Cell Significance Index: -0.9400
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1083
    Cell Significance Index: -0.9400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1118
    Cell Significance Index: -0.8700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1138
    Cell Significance Index: -1.3200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1148
    Cell Significance Index: -1.3500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1156
    Cell Significance Index: -0.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1223
    Cell Significance Index: -1.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1229
    Cell Significance Index: -1.6400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1247
    Cell Significance Index: -1.6800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1255
    Cell Significance Index: -1.4900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1306
    Cell Significance Index: -1.3100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1318
    Cell Significance Index: -1.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1324
    Cell Significance Index: -1.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1330
    Cell Significance Index: -1.3500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1345
    Cell Significance Index: -1.4500
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1369
    Cell Significance Index: -1.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1379
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1382
    Cell Significance Index: -1.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1406
    Cell Significance Index: -1.6600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1427
    Cell Significance Index: -1.6300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1449
    Cell Significance Index: -1.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1453
    Cell Significance Index: -1.9000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1478
    Cell Significance Index: -1.6100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1484
    Cell Significance Index: -1.3400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1505
    Cell Significance Index: -1.6300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1523
    Cell Significance Index: -1.8000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1534
    Cell Significance Index: -1.8400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1539
    Cell Significance Index: -1.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** IL36A is widely expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. Its expression is also observed in other tissues, such as the skin, lung, and liver. 2. **Cytokine Family:** IL36A is a member of the IL-1 family of cytokines, which are known for their ability to regulate inflammation and immune responses. 3. **Signaling Pathways:** IL36A can activate various signaling pathways, including the IL-1 receptor pathway, which leads to the activation of transcription factors, such as NF-κB and IRF3. 4. **Pro-inflammatory Effects:** IL36A has been shown to induce the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, which contribute to the development of inflammation and immune responses. **Pathways and Functions:** 1. **Innate Immune Response:** IL36A plays a crucial role in the innate immune response, where it regulates the production of pro-inflammatory cytokines and activates immune cells, such as macrophages and neutrophils. 2. **Adaptive Immune Response:** IL36A can also influence the adaptive immune response, where it regulates the activity of T cells and B cells, leading to the production of antibodies and the activation of immune responses. 3. **Inflammation and Autoimmune Diseases:** IL36A has been implicated in the pathogenesis of various inflammatory and autoimmune diseases, including psoriasis, rheumatoid arthritis, and multiple sclerosis. 4. **Cellular Signaling:** IL36A can activate various cellular signaling pathways, including the MAPK and PI3K/AKT pathways, leading to the regulation of cell proliferation, survival, and differentiation. **Clinical Significance:** 1. **Inflammatory Diseases:** IL36A has been implicated in the pathogenesis of various inflammatory diseases, including psoriasis, rheumatoid arthritis, and multiple sclerosis. 2. **Autoimmune Diseases:** IL36A may also play a role in the development of autoimmune diseases, such as lupus and Crohn's disease. 3. **Cancer:** IL36A has been shown to regulate the growth and survival of cancer cells, making it a potential target for cancer therapy. 4. **Therapeutic Applications:** IL36A inhibitors have been developed as potential therapeutic agents for the treatment of inflammatory and autoimmune diseases. In conclusion, IL36A plays a complex role in the regulation of inflammation and immune responses. Its expression and signaling pathways have been implicated in the pathogenesis of various inflammatory and autoimmune diseases. Further research is needed to fully understand the role of IL36A in human disease and to develop effective therapeutic strategies for the treatment of inflammatory and autoimmune diseases.

Genular Protein ID: 2714562014

Symbol: IL36A_HUMAN

Name: Interleukin-36 alpha

UniProtKB Accession Codes:

Q9UHA7 B2RAD9 Q53SR7 Q5BLR4 Q7RTZ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10625660

Title: Four new members expand the IL-1 superfamily.

PubMed ID: 10625660

DOI: 10.1074/jbc.275.2.1169

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11466363

Title: Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

PubMed ID: 11466363

DOI: 10.4049/jimmunol.167.3.1440

PubMed ID: 14734551

Title: Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.

PubMed ID: 14734551

DOI: 10.1074/jbc.m400117200

PubMed ID: 16777052

Title: Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.

PubMed ID: 16777052

DOI: 10.1016/j.ab.2006.05.024

PubMed ID: 21965679

Title: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity.

PubMed ID: 21965679

DOI: 10.1074/jbc.m111.267922

PubMed ID: 21881584

Title: Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis.

PubMed ID: 21881584

DOI: 10.1038/jid.2011.234

PubMed ID: 24829417

Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.

PubMed ID: 24829417

DOI: 10.4049/jimmunol.1301481

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

Sequence Information:

  • Length: 158
  • Mass: 17684
  • Checksum: 469AC84306B0E280
  • Sequence:
    • MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG 
NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES 
VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.