Details for: AMY1B

Gene ID: 277

Symbol: AMY1B

Ensembl ID: ENSG00000174876

Description: amylase alpha 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0396
    Cell Significance Index: 0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0112
    Cell Significance Index: 0.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0076
    Cell Significance Index: 0.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0062
    Cell Significance Index: 0.2700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0066
    Cell Significance Index: -3.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0290
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0373
    Cell Significance Index: -4.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0382
    Cell Significance Index: -5.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0584
    Cell Significance Index: -1.1400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0763
    Cell Significance Index: -0.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0787
    Cell Significance Index: -3.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0802
    Cell Significance Index: -0.8300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0874
    Cell Significance Index: -0.7900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1200
    Cell Significance Index: -1.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1804
    Cell Significance Index: -6.3200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1822
    Cell Significance Index: -3.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1862
    Cell Significance Index: -4.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1884
    Cell Significance Index: -5.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1924
    Cell Significance Index: -6.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2009
    Cell Significance Index: -5.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2022
    Cell Significance Index: -1.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2137
    Cell Significance Index: -5.6200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2148
    Cell Significance Index: -1.4000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2287
    Cell Significance Index: -3.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2530
    Cell Significance Index: -6.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2684
    Cell Significance Index: -4.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2703
    Cell Significance Index: -6.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2761
    Cell Significance Index: -4.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2870
    Cell Significance Index: -6.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2897
    Cell Significance Index: -7.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2910
    Cell Significance Index: -5.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2954
    Cell Significance Index: -6.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3062
    Cell Significance Index: -7.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3133
    Cell Significance Index: -6.2900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3169
    Cell Significance Index: -6.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3191
    Cell Significance Index: -6.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3206
    Cell Significance Index: -4.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3346
    Cell Significance Index: -4.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3352
    Cell Significance Index: -5.6100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3440
    Cell Significance Index: -5.8800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3445
    Cell Significance Index: -3.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3503
    Cell Significance Index: -4.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3558
    Cell Significance Index: -8.2200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3634
    Cell Significance Index: -4.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3644
    Cell Significance Index: -6.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3661
    Cell Significance Index: -5.5600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3680
    Cell Significance Index: -4.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3775
    Cell Significance Index: -6.0700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3805
    Cell Significance Index: -3.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3962
    Cell Significance Index: -5.8500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3967
    Cell Significance Index: -4.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3989
    Cell Significance Index: -6.4600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4009
    Cell Significance Index: -4.8800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4024
    Cell Significance Index: -4.7600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4029
    Cell Significance Index: -4.2500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4078
    Cell Significance Index: -5.1600
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.4273
    Cell Significance Index: -3.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4279
    Cell Significance Index: -5.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4290
    Cell Significance Index: -5.9500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.4311
    Cell Significance Index: -4.8800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4388
    Cell Significance Index: -5.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4432
    Cell Significance Index: -5.3000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4469
    Cell Significance Index: -4.9700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4494
    Cell Significance Index: -4.9800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4494
    Cell Significance Index: -6.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4540
    Cell Significance Index: -6.5200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.4546
    Cell Significance Index: -6.0600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4564
    Cell Significance Index: -5.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4608
    Cell Significance Index: -6.6900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4623
    Cell Significance Index: -7.4600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4646
    Cell Significance Index: -6.3800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4673
    Cell Significance Index: -5.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4686
    Cell Significance Index: -5.1900
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.4698
    Cell Significance Index: -4.6600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4701
    Cell Significance Index: -6.5000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.4706
    Cell Significance Index: -4.9800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.4708
    Cell Significance Index: -5.3600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4709
    Cell Significance Index: -6.6000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4711
    Cell Significance Index: -5.9000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.4724
    Cell Significance Index: -4.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4735
    Cell Significance Index: -5.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4740
    Cell Significance Index: -5.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4755
    Cell Significance Index: -6.5200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4766
    Cell Significance Index: -5.9500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4789
    Cell Significance Index: -4.9600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4798
    Cell Significance Index: -6.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4801
    Cell Significance Index: -5.8400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4813
    Cell Significance Index: -5.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4857
    Cell Significance Index: -5.9700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4907
    Cell Significance Index: -5.9700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4925
    Cell Significance Index: -5.9700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4954
    Cell Significance Index: -5.7000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4961
    Cell Significance Index: -6.5100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4972
    Cell Significance Index: -6.3800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4992
    Cell Significance Index: -5.9400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4994
    Cell Significance Index: -6.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure and expression:** AMY1B is a single-copy gene located on chromosome 2q24.3, with a relatively conserved structure across species. Its expression is widespread, with notable presence in salivary glands, lungs, and gastrointestinal tract. 2. **Protein characteristics:** The AMY1B protein is a serine protease, with a molecular weight of approximately 40 kDa. It exhibits high specificity for alpha-1,4-glycosidic bonds, a hallmark of amylase activity. 3. **Cellular localization:** AMY1B is primarily expressed in secretory cells, including salivary acinar cells, plasma cells, and mast cells. Its presence in lung ciliated cells and intestinal epithelial cells highlights its role in extracellular processes. **Pathways and Functions:** 1. **Alpha-amylase activity:** AMY1B catalyzes the hydrolysis of starches into shorter-chain oligosaccharides, a critical step in carbohydrate digestion. This process is essential for the breakdown of dietary polysaccharides into monosaccharides, which can be absorbed by the body. 2. **Calcium ion binding:** AMY1B exhibits calcium ion-binding capabilities, which may influence its enzymatic activity and cellular localization. 3. **Chloride ion binding:** The protein's affinity for chloride ions could modulate its activity and interaction with other cellular components. 4. **Carbohydrate metabolic process:** AMY1B is involved in the degradation of glycans, including starches, glycogen, and glycoproteins. 5. **Digestion and absorption:** By breaking down carbohydrates, AMY1B plays a crucial role in nutrient uptake and energy production. **Clinical Significance:** 1. **Gastrointestinal disorders:** Mutations in the AMY1B gene have been associated with pancreatic exocrine insufficiency, a condition characterized by impaired digestion and malabsorption of nutrients. 2. **Cancer:** Overexpression of AMY1B has been linked to various cancers, including pancreatic, lung, and colon cancers, suggesting its potential role as a tumor marker or therapeutic target. 3. **Neurological disorders:** Dysregulation of AMY1B has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlighting its involvement in extracellular processes beyond digestion. 4. **Infectious diseases:** The protein's presence in plasma cells and mast cells suggests its potential role in immune responses and inflammation. In conclusion, the AMY1B gene is a multifaceted molecule with far-reaching implications in digestion, immune function, and disease pathology. Further research is necessary to fully elucidate its mechanisms and therapeutic potential, but its significance in human biology and disease is already clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.