IGHV3 48 | ENSG00000211964 | NCBI 28424

Details for: IGHV3 48

Gene ID: 28424

Symbol: IGHV3 48

Ensembl ID: ENSG00000211964

Description: immunoglobulin heavy variable 3-48

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.4466
Cell Significance Index: 6.9100
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0683
Cell Significance Index: 0.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0050
Cell Significance Index: -3.7800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0078
Cell Significance Index: -1.0000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0196
Cell Significance Index: -0.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0428
Cell Significance Index: -4.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0696
Cell Significance Index: -4.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0735
Cell Significance Index: -3.8200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0784
Cell Significance Index: -13.3800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0842
Cell Significance Index: -10.8800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0940
Cell Significance Index: -2.5200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1246
Cell Significance Index: -1.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1362
Cell Significance Index: -3.7100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1479
Cell Significance Index: -11.0200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1511
Cell Significance Index: -4.4500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1539
Cell Significance Index: -2.1600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1552
Cell Significance Index: -3.8700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1586
Cell Significance Index: -4.0400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1628
Cell Significance Index: -1.8200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1636
Cell Significance Index: -4.1800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1858
Cell Significance Index: -4.5000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1925
Cell Significance Index: -3.2700
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.1963
Cell Significance Index: -2.3300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1973
Cell Significance Index: -4.9300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2087
Cell Significance Index: -4.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2158
Cell Significance Index: -16.5600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2173
Cell Significance Index: -3.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2262
Cell Significance Index: -4.1800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2372
Cell Significance Index: -4.0600
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2394
Cell Significance Index: -3.4300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2430
Cell Significance Index: -11.3300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2440
Cell Significance Index: -3.3200
Cell Name: keratocyte (CL0002363)
Fold Change: -0.2452
Cell Significance Index: -3.8900
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2497
Cell Significance Index: -2.7900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2509
Cell Significance Index: -3.1700
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2618
Cell Significance Index: -3.5900
Cell Name: monocyte (CL0000576)
Fold Change: -0.2729
Cell Significance Index: -3.1400
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2809
Cell Significance Index: -3.3100
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2858
Cell Significance Index: -4.1800
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.2862
Cell Significance Index: -2.3000
Cell Name: blood cell (CL0000081)
Fold Change: -0.2880
Cell Significance Index: -2.4600
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.2896
Cell Significance Index: -2.7800
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2999
Cell Significance Index: -3.6200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.3021
Cell Significance Index: -3.5700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3037
Cell Significance Index: -3.9300
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3083
Cell Significance Index: -3.1500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3123
Cell Significance Index: -2.0800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3188
Cell Significance Index: -4.0400
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3230
Cell Significance Index: -4.1500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3246
Cell Significance Index: -4.0200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3258
Cell Significance Index: -3.4300
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3265
Cell Significance Index: -3.0300
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.3316
Cell Significance Index: -3.6400
Cell Name: B cell (CL0000236)
Fold Change: -0.3334
Cell Significance Index: -3.9400
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3428
Cell Significance Index: -3.4800
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3444
Cell Significance Index: -4.0000
Cell Name: podocyte (CL0000653)
Fold Change: -0.3444
Cell Significance Index: -3.9500
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3458
Cell Significance Index: -4.3200
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3459
Cell Significance Index: -3.6800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3463
Cell Significance Index: -3.9200
Cell Name: helper T cell (CL0000912)
Fold Change: -0.3464
Cell Significance Index: -4.9200
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3482
Cell Significance Index: -4.5700
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.3512
Cell Significance Index: -2.6800
Cell Name: glial cell (CL0000125)
Fold Change: -0.3523
Cell Significance Index: -3.8600
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.3538
Cell Significance Index: -2.5000
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.3567
Cell Significance Index: -3.4900
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3574
Cell Significance Index: -2.9500
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.3634
Cell Significance Index: -4.3200
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3677
Cell Significance Index: -3.2800
Cell Name: myelocyte (CL0002193)
Fold Change: -0.3744
Cell Significance Index: -4.0000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3765
Cell Significance Index: -4.0000
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3767
Cell Significance Index: -4.1200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.3775
Cell Significance Index: -4.0700
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.3799
Cell Significance Index: -4.2200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3842
Cell Significance Index: -4.5400
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.3873
Cell Significance Index: -4.5000
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3875
Cell Significance Index: -4.2900
Cell Name: paneth cell (CL0000510)
Fold Change: -0.3896
Cell Significance Index: -4.0300
Cell Name: platelet (CL0000233)
Fold Change: -0.3907
Cell Significance Index: -4.0200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3914
Cell Significance Index: -11.2200
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.3945
Cell Significance Index: -4.1900
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.3948
Cell Significance Index: -4.5800
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3953
Cell Significance Index: -4.2500
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.3954
Cell Significance Index: -3.9000
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3957
Cell Significance Index: -4.0400
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.3970
Cell Significance Index: -4.0300
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.3980
Cell Significance Index: -4.5800
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.4010
Cell Significance Index: -2.2300
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4027
Cell Significance Index: -4.4600
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.4046
Cell Significance Index: -4.5000
Cell Name: lung goblet cell (CL1000143)
Fold Change: -0.4095
Cell Significance Index: -4.0200
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4098
Cell Significance Index: -5.3500
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.4105
Cell Significance Index: -4.0500
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.4117
Cell Significance Index: -4.3800
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.4118
Cell Significance Index: -4.4400
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.4137
Cell Significance Index: -3.9400
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4163
Cell Significance Index: -4.5900
Cell Name: club cell (CL0000158)
Fold Change: -0.4213
Cell Significance Index: -4.5900
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4215
Cell Significance Index: -4.7500
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.4226
Cell Significance Index: -4.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGHV3-48 is a member of the immunoglobulin heavy chain gene family and is characterized by its unique variable region sequence. This gene is highly expressed in cells of the immune system, particularly in B cells, which are responsible for producing antibodies. IGHV3-48 has been shown to be involved in the activation of B cell receptors, leading to the generation of second messengers and the initiation of immune responses. **Pathways and Functions:** IGHV3-48 is involved in multiple pathways that regulate immune responses, including: 1. **Antigen binding and uptake**: IGHV3-48 plays a crucial role in the binding and uptake of antigens by B cells, which is essential for the activation of immune responses. 2. **B cell receptor signaling**: IGHV3-48 is involved in the signaling of B cell receptors, leading to the activation of downstream pathways that regulate immune responses. 3. **Complement activation**: IGHV3-48 is involved in the activation of the complement cascade, which is a key component of the innate immune response. 4. **Fc receptor signaling**: IGHV3-48 is involved in the signaling of Fc receptors, which are essential for the regulation of immune responses, including phagocytosis and antibody-dependent cellular cytotoxicity. 5. **Innate immune system**: IGHV3-48 is involved in the regulation of innate immune responses, including the activation of complement and the production of cytokines. **Clinical Significance:** IGHV3-48 has been implicated in various diseases, including: 1. **Leishmaniasis**: IGHV3-48 has been shown to play a crucial role in the regulation of immune responses to Leishmania parasites, which are responsible for this disease. 2. **Infectious diseases**: IGHV3-48 has been implicated in the regulation of immune responses to various infectious diseases, including viral and bacterial infections. 3. **Cancer**: IGHV3-48 has been shown to be involved in the regulation of immune responses in cancer, including the activation of immune cells and the production of cytokines. 4. **Autoimmune diseases**: IGHV3-48 has been implicated in the regulation of immune responses in autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, IGHV3-48 is a complex gene that plays a crucial role in the regulation of immune responses. Its involvement in multiple pathways, including antigen binding, B cell receptor signaling, and complement activation, makes it an essential component of the adaptive immune system. Further research is needed to fully understand the clinical significance of IGHV3-48 and its potential applications in the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.