Details for: IGHV3 35

Gene ID: 28432

Symbol: IGHV3 35

Ensembl ID: ENSG00000211957

Description: immunoglobulin heavy variable 3-35 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0812
    Cell Significance Index: 0.8300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0104
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0127
    Cell Significance Index: -0.1700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0135
    Cell Significance Index: -0.2000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0145
    Cell Significance Index: -0.1000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0225
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0321
    Cell Significance Index: -0.2600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0334
    Cell Significance Index: -0.2800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0350
    Cell Significance Index: -0.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0356
    Cell Significance Index: -0.9100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0361
    Cell Significance Index: -0.9200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0367
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0373
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0407
    Cell Significance Index: -0.3400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0436
    Cell Significance Index: -0.3500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0475
    Cell Significance Index: -0.6200
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0509
    Cell Significance Index: -0.5400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0510
    Cell Significance Index: -0.5500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0527
    Cell Significance Index: -0.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0578
    Cell Significance Index: -0.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0578
    Cell Significance Index: -0.7300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0579
    Cell Significance Index: -0.6000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0584
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0592
    Cell Significance Index: -0.6300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0594
    Cell Significance Index: -0.5300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0597
    Cell Significance Index: -0.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0606
    Cell Significance Index: -0.7200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0611
    Cell Significance Index: -0.7900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0614
    Cell Significance Index: -0.6800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0616
    Cell Significance Index: -0.8100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0621
    Cell Significance Index: -0.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0626
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0639
    Cell Significance Index: -1.0900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0640
    Cell Significance Index: -0.5900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0655
    Cell Significance Index: -0.7300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0657
    Cell Significance Index: -0.6100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0660
    Cell Significance Index: -0.6800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0664
    Cell Significance Index: -0.7700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0667
    Cell Significance Index: -0.8000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0670
    Cell Significance Index: -0.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0670
    Cell Significance Index: -0.8900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0680
    Cell Significance Index: -0.6900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0680
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0695
    Cell Significance Index: -0.6500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0698
    Cell Significance Index: -0.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0703
    Cell Significance Index: -0.8300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0719
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0723
    Cell Significance Index: -0.7300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0725
    Cell Significance Index: -0.7300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0726
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0728
    Cell Significance Index: -0.6900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0728
    Cell Significance Index: -0.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0743
    Cell Significance Index: -0.8600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0752
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0756
    Cell Significance Index: -0.7100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0764
    Cell Significance Index: -0.6900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0765
    Cell Significance Index: -0.8800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0769
    Cell Significance Index: -0.8100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0775
    Cell Significance Index: -0.5900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0784
    Cell Significance Index: -0.7300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0805
    Cell Significance Index: -0.8800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0812
    Cell Significance Index: -0.7100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0831
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0832
    Cell Significance Index: -0.8000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0844
    Cell Significance Index: -0.8500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0858
    Cell Significance Index: -0.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0891
    Cell Significance Index: -0.9100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0892
    Cell Significance Index: -0.9100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0897
    Cell Significance Index: -0.8300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0909
    Cell Significance Index: -0.7700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0916
    Cell Significance Index: -0.9500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0941
    Cell Significance Index: -0.7000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0941
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0952
    Cell Significance Index: -0.8800
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0967
    Cell Significance Index: -0.8500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0974
    Cell Significance Index: -0.8300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0987
    Cell Significance Index: -0.8700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0988
    Cell Significance Index: -0.8500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0990
    Cell Significance Index: -0.7700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0991
    Cell Significance Index: -0.9000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1075
    Cell Significance Index: -0.7000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1083
    Cell Significance Index: -0.9600
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1090
    Cell Significance Index: -0.9500
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1146
    Cell Significance Index: -0.8800
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1170
    Cell Significance Index: -0.9400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1229
    Cell Significance Index: -0.6700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1245
    Cell Significance Index: -0.8800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1268
    Cell Significance Index: -0.6000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1404
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1527
    Cell Significance Index: -0.9600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1569
    Cell Significance Index: -0.8400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1919
    Cell Significance Index: -0.9600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2395
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional nature:** IGHV3-35 is a non-functional immunoglobulin heavy chain variable region gene, meaning it does not encode for a functional antibody. 2. **Wide expression:** IGHV3-35 is significantly expressed in various cells, including hematopoietic cells, lymphocytes, goblet cells, neoplastic cells, and intestinal epithelial cells. 3. **Cell-type specific expression:** While IGHV3-35 is widely expressed, its expression is cell-type specific, with varying levels of expression in different cell types. **Pathways and Functions:** IGHV3-35 is involved in several biological pathways, including: 1. **Antigen binding:** Although IGHV3-35 is non-functional, it may still contribute to the regulation of antigen binding in the immune system. 2. **Extracellular region:** IGHV3-35 is part of the extracellular region of immunoglobulins, which plays a crucial role in the immune response. 3. **Immunoglobulin complex:** IGHV3-35 is part of the immunoglobulin complex, which is composed of heavy and light chains. 4. **Immunoglobulin-mediated immune response:** IGHV3-35 may contribute to the regulation of the immunoglobulin-mediated immune response, although its non-functional nature limits its potential impact. **Clinical Significance:** IGHV3-35 has several clinical implications, including: 1. **Immune system dysregulation:** The widespread expression of IGHV3-35 in various cells suggests that it may play a role in immune system dysregulation, particularly in the context of autoimmune diseases or cancer. 2. **Cancer association:** The expression of IGHV3-35 in neoplastic cells and abnormal cells suggests that it may be involved in cancer development or progression. 3. **Intestinal health:** The expression of IGHV3-35 in intestinal epithelial cells and goblet cells suggests that it may play a role in maintaining intestinal health and preventing diseases such as inflammatory bowel disease. In conclusion, the IGHV3-35 gene is a non-functional immunoglobulin heavy chain variable region gene with widespread expression in the immune system. Its non-functional nature limits its potential impact, but its expression in various cell types suggests that it may play a role in immune system dysregulation, cancer, and intestinal health. Further research is needed to fully understand the functional implications of IGHV3-35 and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.