Details for: IGHV3 35

Gene ID: 28432

Symbol: IGHV3 35

Ensembl ID: ENSG00000211957

Description: immunoglobulin heavy variable 3-35 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.63
    Marker Score: 2,412
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.51
    Marker Score: 1,269
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,812
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,577
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,730
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 236
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 147
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 58
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 252
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional nature:** IGHV3-35 is a non-functional immunoglobulin heavy chain variable region gene, meaning it does not encode for a functional antibody. 2. **Wide expression:** IGHV3-35 is significantly expressed in various cells, including hematopoietic cells, lymphocytes, goblet cells, neoplastic cells, and intestinal epithelial cells. 3. **Cell-type specific expression:** While IGHV3-35 is widely expressed, its expression is cell-type specific, with varying levels of expression in different cell types. **Pathways and Functions:** IGHV3-35 is involved in several biological pathways, including: 1. **Antigen binding:** Although IGHV3-35 is non-functional, it may still contribute to the regulation of antigen binding in the immune system. 2. **Extracellular region:** IGHV3-35 is part of the extracellular region of immunoglobulins, which plays a crucial role in the immune response. 3. **Immunoglobulin complex:** IGHV3-35 is part of the immunoglobulin complex, which is composed of heavy and light chains. 4. **Immunoglobulin-mediated immune response:** IGHV3-35 may contribute to the regulation of the immunoglobulin-mediated immune response, although its non-functional nature limits its potential impact. **Clinical Significance:** IGHV3-35 has several clinical implications, including: 1. **Immune system dysregulation:** The widespread expression of IGHV3-35 in various cells suggests that it may play a role in immune system dysregulation, particularly in the context of autoimmune diseases or cancer. 2. **Cancer association:** The expression of IGHV3-35 in neoplastic cells and abnormal cells suggests that it may be involved in cancer development or progression. 3. **Intestinal health:** The expression of IGHV3-35 in intestinal epithelial cells and goblet cells suggests that it may play a role in maintaining intestinal health and preventing diseases such as inflammatory bowel disease. In conclusion, the IGHV3-35 gene is a non-functional immunoglobulin heavy chain variable region gene with widespread expression in the immune system. Its non-functional nature limits its potential impact, but its expression in various cell types suggests that it may play a role in immune system dysregulation, cancer, and intestinal health. Further research is needed to fully understand the functional implications of IGHV3-35 and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.