Details for: TRBV25 1

Gene ID: 28562

Symbol: TRBV25 1

Ensembl ID: ENSG00000282499

Description: T cell receptor beta variable 25-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3467
    Cell Significance Index: 32.6200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1595
    Cell Significance Index: 0.8700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0905
    Cell Significance Index: 0.7500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0554
    Cell Significance Index: 0.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0176
    Cell Significance Index: 0.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0062
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0080
    Cell Significance Index: -1.6000
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0103
    Cell Significance Index: -0.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0197
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0238
    Cell Significance Index: -0.9000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0252
    Cell Significance Index: -0.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0267
    Cell Significance Index: -0.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0270
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0292
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0323
    Cell Significance Index: -0.4400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0366
    Cell Significance Index: -0.4500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0375
    Cell Significance Index: -0.4500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0377
    Cell Significance Index: -0.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0380
    Cell Significance Index: -0.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0386
    Cell Significance Index: -0.5000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0444
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0475
    Cell Significance Index: -1.2100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0484
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0486
    Cell Significance Index: -0.3800
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0494
    Cell Significance Index: -0.4600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0500
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0548
    Cell Significance Index: -0.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0548
    Cell Significance Index: -0.9300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0556
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0566
    Cell Significance Index: -0.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0584
    Cell Significance Index: -0.8300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0597
    Cell Significance Index: -0.7100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0605
    Cell Significance Index: -0.5200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0644
    Cell Significance Index: -0.7200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0646
    Cell Significance Index: -0.5500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0646
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0654
    Cell Significance Index: -0.9500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0658
    Cell Significance Index: -0.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0659
    Cell Significance Index: -0.7000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0667
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0675
    Cell Significance Index: -0.7000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0679
    Cell Significance Index: -1.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0679
    Cell Significance Index: -0.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0701
    Cell Significance Index: -0.9200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0714
    Cell Significance Index: -1.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0726
    Cell Significance Index: -1.0000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0729
    Cell Significance Index: -1.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0743
    Cell Significance Index: -1.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0749
    Cell Significance Index: -0.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0762
    Cell Significance Index: -1.4900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0773
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0786
    Cell Significance Index: -1.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0793
    Cell Significance Index: -0.9200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0799
    Cell Significance Index: -0.9200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0800
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0803
    Cell Significance Index: -0.6500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0804
    Cell Significance Index: -0.9200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0806
    Cell Significance Index: -0.6800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0811
    Cell Significance Index: -0.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0814
    Cell Significance Index: -1.6100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0821
    Cell Significance Index: -0.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0822
    Cell Significance Index: -1.5200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0827
    Cell Significance Index: -0.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0834
    Cell Significance Index: -0.9600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0839
    Cell Significance Index: -0.8200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0840
    Cell Significance Index: -0.9400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0840
    Cell Significance Index: -1.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0854
    Cell Significance Index: -0.9300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0855
    Cell Significance Index: -1.0100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0866
    Cell Significance Index: -1.0300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0867
    Cell Significance Index: -1.0200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0869
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0871
    Cell Significance Index: -1.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0876
    Cell Significance Index: -1.1100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0878
    Cell Significance Index: -0.8900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0882
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0883
    Cell Significance Index: -0.8900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0888
    Cell Significance Index: -0.9700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0888
    Cell Significance Index: -0.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0890
    Cell Significance Index: -0.9700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0892
    Cell Significance Index: -0.8100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0895
    Cell Significance Index: -0.9600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0901
    Cell Significance Index: -0.9200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0924
    Cell Significance Index: -0.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0946
    Cell Significance Index: -1.0200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0955
    Cell Significance Index: -0.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0956
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0959
    Cell Significance Index: -0.9000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0972
    Cell Significance Index: -1.1200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0973
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRBV25.1 gene is located on chromosome 7q35.3 and is significantly expressed in hematopoietic cells, goblet cells, neoplastic cells, and other cell types. 2. **T Cell Receptor Structure:** The TRBV25.1 gene encodes a variable region of the T cell receptor beta chain, which is a key component of the T cell receptor complex. 3. **Diversity and Variation:** The TRBV25.1 gene is part of the T cell receptor beta (TRBC) gene family, which is responsible for generating a vast repertoire of T cell receptors. The TRBV25.1 gene is one of the 34 known TRBC genes, and its expression is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBV25.1 gene plays a critical role in the adaptive immune response, enabling T cells to recognize and respond to specific antigens. 2. **Cell Surface Receptor Signaling:** The TRBV25.1 gene is part of the T cell receptor complex, which is a cell surface receptor that recognizes antigens and triggers a signaling cascade. 3. **Plasma Membrane and T Cell Receptor Complex:** The TRBV25.1 gene is located on the plasma membrane and is integrated into the T cell receptor complex, where it interacts with other components of the complex to recognize and respond to antigens. 4. **Regulation of Immune Responses:** The TRBV25.1 gene is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms, including the activity of transcription factors, such as TCF-1 and NFAT, and the regulation of gene expression by microRNAs. **Clinical Significance:** 1. **Immune-Related Disorders:** The TRBV25.1 gene has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and cancer, such as leukemia and lymphoma. 2. **Cancer Immunotherapy:** The TRBV25.1 gene has been identified as a potential target for cancer immunotherapy, as it is involved in the recognition and response to tumor antigens. 3. **Infectious Diseases:** The TRBV25.1 gene has been implicated in the pathogenesis of infectious diseases, such as HIV and tuberculosis, where it plays a role in the recognition and response to viral and bacterial antigens. 4. **T Cell Receptor Engineering:** The TRBV25.1 gene has been used as a model for T cell receptor engineering, where it is used to design and engineer T cell receptors for cancer immunotherapy and other applications. In conclusion, the TRBV25.1 gene is a critical component of the adaptive immune system, and its dysregulation has been implicated in various immune-related disorders and cancer. Further research is needed to fully understand the complexities of the TRBV25.1 gene and its role in immune responses and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.