Details for: TRBV12 5

Gene ID: 28575

Symbol: TRBV12 5

Ensembl ID: ENSG00000275158

Description: T cell receptor beta variable 12-5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7051
    Cell Significance Index: 17.0800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3362
    Cell Significance Index: 4.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1920
    Cell Significance Index: 3.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0202
    Cell Significance Index: 0.1100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0028
    Cell Significance Index: -0.0500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0130
    Cell Significance Index: -0.1200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0149
    Cell Significance Index: -0.1300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0154
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0270
    Cell Significance Index: -0.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0272
    Cell Significance Index: -0.3700
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0282
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0294
    Cell Significance Index: -0.5000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0302
    Cell Significance Index: -0.2500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0356
    Cell Significance Index: -0.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0377
    Cell Significance Index: -0.9600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0395
    Cell Significance Index: -0.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0409
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0434
    Cell Significance Index: -0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0443
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0465
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0509
    Cell Significance Index: -1.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0524
    Cell Significance Index: -0.6900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0545
    Cell Significance Index: -0.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0550
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0577
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0578
    Cell Significance Index: -0.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0579
    Cell Significance Index: -1.0700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0605
    Cell Significance Index: -0.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0606
    Cell Significance Index: -0.5300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0680
    Cell Significance Index: -0.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0685
    Cell Significance Index: -0.8800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0690
    Cell Significance Index: -0.8000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0695
    Cell Significance Index: -0.7000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0698
    Cell Significance Index: -0.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0718
    Cell Significance Index: -1.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0718
    Cell Significance Index: -1.0900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0735
    Cell Significance Index: -0.8100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0736
    Cell Significance Index: -0.7800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0747
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0765
    Cell Significance Index: -0.9400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0768
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0770
    Cell Significance Index: -0.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0772
    Cell Significance Index: -1.0100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0778
    Cell Significance Index: -0.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0799
    Cell Significance Index: -1.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0800
    Cell Significance Index: -1.0500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0804
    Cell Significance Index: -0.5600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0805
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0806
    Cell Significance Index: -0.8500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0819
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0839
    Cell Significance Index: -0.8700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0842
    Cell Significance Index: -1.0100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0850
    Cell Significance Index: -0.9200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0852
    Cell Significance Index: -0.9800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0855
    Cell Significance Index: -1.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0859
    Cell Significance Index: -0.7900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0863
    Cell Significance Index: -0.9300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0865
    Cell Significance Index: -0.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0896
    Cell Significance Index: -1.0100
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.0903
    Cell Significance Index: -0.6800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0904
    Cell Significance Index: -1.1000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0908
    Cell Significance Index: -0.8400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0911
    Cell Significance Index: -0.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0921
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0927
    Cell Significance Index: -0.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0931
    Cell Significance Index: -0.9900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0941
    Cell Significance Index: -0.8900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0948
    Cell Significance Index: -1.1200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0948
    Cell Significance Index: -1.1200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0960
    Cell Significance Index: -0.9800
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0962
    Cell Significance Index: -0.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0974
    Cell Significance Index: -0.8300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0985
    Cell Significance Index: -1.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0985
    Cell Significance Index: -1.1000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0989
    Cell Significance Index: -1.0100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0994
    Cell Significance Index: -1.1000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1002
    Cell Significance Index: -0.9100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1004
    Cell Significance Index: -0.9900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1005
    Cell Significance Index: -0.9800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1006
    Cell Significance Index: -0.6700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1015
    Cell Significance Index: -0.7900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1016
    Cell Significance Index: -1.0700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1025
    Cell Significance Index: -1.0600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1027
    Cell Significance Index: -0.9100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1032
    Cell Significance Index: -1.1900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1040
    Cell Significance Index: -1.0700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1052
    Cell Significance Index: -1.0500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1052
    Cell Significance Index: -0.9500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1052
    Cell Significance Index: -0.9200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1061
    Cell Significance Index: -0.9400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1076
    Cell Significance Index: -0.8900
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1079
    Cell Significance Index: -0.9400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1083
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The TRBV12-5 gene is located on chromosome 11q22.3, within the T cell receptor complex. 2. **Expression:** TRBV12-5 is expressed in a wide range of T cell subsets, including CD4-positive and CD8-positive T cells, and is significantly upregulated in response to antigen presentation. 3. **Function:** The TRBV12-5 gene encodes for a variable region of the TCR beta chain, which is essential for the specific recognition of antigens. 4. **Cellular Localization:** The TCR complex, including TRBV12-5, is localized on the surface of T cells, where it interacts with MHC molecules and other co-receptors to recognize antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV12-5 plays a critical role in the adaptive immune response by allowing T cells to recognize and respond to specific antigens. 2. **TCR Signaling Pathway:** The interaction between the TCR complex, including TRBV12-5, and MHC molecules triggers a signaling cascade that activates T cell activation and proliferation. 3. **Cell Surface Receptor Signaling Pathway:** TRBV12-5 is involved in the signaling pathway of cell surface receptors, including the TCR, which regulates T cell activation and function. 4. **Plasma Membrane:** The TCR complex, including TRBV12-5, is localized on the plasma membrane, where it interacts with antigens and other molecules to regulate T cell function. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRBV12-5 expression has been implicated in various autoimmune diseases, including multiple sclerosis and type 1 diabetes. 2. **Cancer:** The TCR complex, including TRBV12-5, plays a critical role in the recognition and elimination of cancer cells. Dysregulation of TRBV12-5 expression has been associated with various types of cancer. 3. **Infectious Diseases:** TRBV12-5 is involved in the recognition and response to infectious diseases, including HIV and tuberculosis. 4. **Immunotherapy:** Understanding the role of TRBV12-5 in the adaptive immune response has important implications for the development of immunotherapies, including cancer vaccines and adoptive T cell therapy. In conclusion, TRBV12-5 is a critical component of the adaptive immune system, playing a pivotal role in the recognition and elimination of pathogens. Further research into the function and regulation of TRBV12-5 has important implications for the understanding and treatment of various diseases, including autoimmune disorders, cancer, and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.