Details for: TRBV5 6

Gene ID: 28609

Symbol: TRBV5 6

Ensembl ID: ENSG00000211728

Description: T cell receptor beta variable 5-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4351
    Cell Significance Index: 4.8600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3008
    Cell Significance Index: 1.6400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.1389
    Cell Significance Index: 1.2500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1351
    Cell Significance Index: 1.1200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0757
    Cell Significance Index: 0.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2300
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0096
    Cell Significance Index: -0.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0099
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0201
    Cell Significance Index: -4.0300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0213
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0247
    Cell Significance Index: -0.2000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0363
    Cell Significance Index: -0.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0382
    Cell Significance Index: -0.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0417
    Cell Significance Index: -1.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0422
    Cell Significance Index: -1.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0528
    Cell Significance Index: -0.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0703
    Cell Significance Index: -1.8000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0713
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0720
    Cell Significance Index: -3.7400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0756
    Cell Significance Index: -0.6500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0760
    Cell Significance Index: -0.9400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0909
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0918
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1008
    Cell Significance Index: -2.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1055
    Cell Significance Index: -1.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1076
    Cell Significance Index: -1.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1099
    Cell Significance Index: -1.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1106
    Cell Significance Index: -1.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1121
    Cell Significance Index: -1.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1136
    Cell Significance Index: -2.9000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1198
    Cell Significance Index: -1.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1223
    Cell Significance Index: -2.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1225
    Cell Significance Index: -2.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1392
    Cell Significance Index: -1.8500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1396
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1407
    Cell Significance Index: -1.7300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1439
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1464
    Cell Significance Index: -1.7400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1476
    Cell Significance Index: -1.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1477
    Cell Significance Index: -1.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1480
    Cell Significance Index: -2.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1507
    Cell Significance Index: -1.3000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1532
    Cell Significance Index: -1.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1537
    Cell Significance Index: -2.8400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1582
    Cell Significance Index: -1.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1586
    Cell Significance Index: -3.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1599
    Cell Significance Index: -1.8300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1667
    Cell Significance Index: -1.2400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1667
    Cell Significance Index: -2.7000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1700
    Cell Significance Index: -2.0000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1706
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1773
    Cell Significance Index: -1.8700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1781
    Cell Significance Index: -1.9400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1793
    Cell Significance Index: -2.0800
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1811
    Cell Significance Index: -1.7700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1826
    Cell Significance Index: -1.8400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1840
    Cell Significance Index: -1.7000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1869
    Cell Significance Index: -1.5800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1871
    Cell Significance Index: -1.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1875
    Cell Significance Index: -2.4600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1924
    Cell Significance Index: -1.7800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1927
    Cell Significance Index: -1.7700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1950
    Cell Significance Index: -1.6300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1959
    Cell Significance Index: -2.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2038
    Cell Significance Index: -2.4200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2062
    Cell Significance Index: -2.0100
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2071
    Cell Significance Index: -1.5600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2073
    Cell Significance Index: -1.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2074
    Cell Significance Index: -2.6700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2076
    Cell Significance Index: -2.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2103
    Cell Significance Index: -2.2700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2104
    Cell Significance Index: -1.7400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2133
    Cell Significance Index: -2.9900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2160
    Cell Significance Index: -1.6800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2164
    Cell Significance Index: -2.8300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2165
    Cell Significance Index: -2.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2182
    Cell Significance Index: -3.1000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2214
    Cell Significance Index: -1.9400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2216
    Cell Significance Index: -1.8700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2225
    Cell Significance Index: -2.8200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2247
    Cell Significance Index: -1.9700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2249
    Cell Significance Index: -1.7300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2251
    Cell Significance Index: -2.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2252
    Cell Significance Index: -2.9400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2278
    Cell Significance Index: -2.3100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2311
    Cell Significance Index: -2.6600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2329
    Cell Significance Index: -2.6800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2341
    Cell Significance Index: -2.3900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2345
    Cell Significance Index: -2.1300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2378
    Cell Significance Index: -2.8100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2429
    Cell Significance Index: -2.6900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2484
    Cell Significance Index: -3.6200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2498
    Cell Significance Index: -3.1200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2515
    Cell Significance Index: -2.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2571
    Cell Significance Index: -2.2700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2592
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The TRBV5-6 gene is part of the TCR beta (TCRB) locus, which consists of multiple gene variants that encode distinct V, D, and J segments. The TRBV5-6 gene variant possesses a unique V sequence, which is crucial for antigen recognition. 2. **Expression Patterns:** The TRBV5-6 gene is expressed in a diverse range of cell types, including macrophages, hematopoietic cells, and alpha-beta T cells. This broad expression pattern underscores the gene's involvement in various immune processes. 3. **Cell Surface Localization:** The TRBV5-6 gene product is localized to the cell surface, where it interacts with other TCR components and antigen-presenting molecules to facilitate immune responses. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBV5-6 gene plays a critical role in the adaptive immune response, particularly in the recognition and binding of antigens. The unique V sequence of this gene variant enables the TCR to recognize specific epitopes on pathogens or tumor cells. 2. **TCR Signaling Pathway:** The TRBV5-6 gene product interacts with other TCR components and antigen-presenting molecules to activate the TCR signaling pathway. This pathway involves the activation of downstream signaling molecules, including ZAP-70 and LCK, which ultimately lead to the activation of T cells. 3. **Cell Surface Receptor Signaling Pathway:** The TRBV5-6 gene product is part of the cell surface receptor signaling pathway, which involves the interaction of the TCR with other receptors and signaling molecules to modulate immune responses. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in the TRBV5-6 gene have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. These alterations can disrupt the normal functioning of the TCR, leading to excessive or inadequate immune responses. 2. **Cancer Immunotherapy:** The TRBV5-6 gene has been identified as a potential target for cancer immunotherapy. The unique V sequence of this gene variant can be exploited to develop novel T cell-based therapies for cancer treatment. 3. **Transplantation and Infection:** The TRBV5-6 gene plays a crucial role in the recognition and binding of antigens, which is essential for the immune system's ability to distinguish between self and non-self. Alterations in this gene can impair the immune system's ability to recognize and respond to pathogens or transplanted tissues. In conclusion, the TRBV5-6 gene is a critical component of the adaptive immune system, and its unique V sequence plays a pivotal role in the recognition and binding of antigens. Further research on this gene variant is essential to elucidate its mechanisms of action and to explore its potential applications in immunotherapy and disease prevention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.