Details for: TRAV26 1

Gene ID: 28657

Symbol: TRAV26 1

Ensembl ID: ENSG00000211807

Description: T cell receptor alpha variable 26-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3998
    Cell Significance Index: 2.1800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3821
    Cell Significance Index: 4.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1686
    Cell Significance Index: 2.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1357
    Cell Significance Index: 1.6500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0228
    Cell Significance Index: 0.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0154
    Cell Significance Index: -0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0188
    Cell Significance Index: -3.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0329
    Cell Significance Index: -0.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0341
    Cell Significance Index: -1.4800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0417
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0575
    Cell Significance Index: -2.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0634
    Cell Significance Index: -2.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0722
    Cell Significance Index: -1.7500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0848
    Cell Significance Index: -0.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0906
    Cell Significance Index: -1.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0915
    Cell Significance Index: -1.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0991
    Cell Significance Index: -1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1032
    Cell Significance Index: -2.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1176
    Cell Significance Index: -1.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1178
    Cell Significance Index: -3.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1205
    Cell Significance Index: -3.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1283
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1305
    Cell Significance Index: -3.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1425
    Cell Significance Index: -3.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1580
    Cell Significance Index: -3.9400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1624
    Cell Significance Index: -1.7600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1756
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1764
    Cell Significance Index: -1.7800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1791
    Cell Significance Index: -1.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1819
    Cell Significance Index: -3.9300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1866
    Cell Significance Index: -3.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1886
    Cell Significance Index: -3.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1903
    Cell Significance Index: -3.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1928
    Cell Significance Index: -3.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1936
    Cell Significance Index: -2.6600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1958
    Cell Significance Index: -2.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1993
    Cell Significance Index: -3.9400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2002
    Cell Significance Index: -3.9400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2015
    Cell Significance Index: -3.2400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2022
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2032
    Cell Significance Index: -2.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2066
    Cell Significance Index: -2.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2087
    Cell Significance Index: -3.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2094
    Cell Significance Index: -3.8700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2151
    Cell Significance Index: -2.5400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2205
    Cell Significance Index: -2.0700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2225
    Cell Significance Index: -3.0000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2238
    Cell Significance Index: -3.5900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2251
    Cell Significance Index: -3.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2273
    Cell Significance Index: -2.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2276
    Cell Significance Index: -3.8900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2282
    Cell Significance Index: -2.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2333
    Cell Significance Index: -2.4200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2365
    Cell Significance Index: -1.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2443
    Cell Significance Index: -3.5600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2454
    Cell Significance Index: -2.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2469
    Cell Significance Index: -3.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2470
    Cell Significance Index: -2.8700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2568
    Cell Significance Index: -2.3100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2594
    Cell Significance Index: -3.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2615
    Cell Significance Index: -3.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2617
    Cell Significance Index: -3.5600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2626
    Cell Significance Index: -2.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2632
    Cell Significance Index: -2.5300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2637
    Cell Significance Index: -2.5700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2651
    Cell Significance Index: -2.4800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2662
    Cell Significance Index: -3.4500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2677
    Cell Significance Index: -3.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2713
    Cell Significance Index: -3.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2730
    Cell Significance Index: -1.7800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2763
    Cell Significance Index: -2.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2766
    Cell Significance Index: -4.2800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2770
    Cell Significance Index: -3.6400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2860
    Cell Significance Index: -3.8000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2896
    Cell Significance Index: -3.7800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2953
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2967
    Cell Significance Index: -2.5600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2981
    Cell Significance Index: -3.8900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3007
    Cell Significance Index: -3.0700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3025
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3035
    Cell Significance Index: -3.7300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3052
    Cell Significance Index: -2.9300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3059
    Cell Significance Index: -2.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3059
    Cell Significance Index: -3.5200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3064
    Cell Significance Index: -2.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3085
    Cell Significance Index: -3.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3106
    Cell Significance Index: -3.6700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3109
    Cell Significance Index: -3.7500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.3118
    Cell Significance Index: -1.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3157
    Cell Significance Index: -3.4400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3162
    Cell Significance Index: -4.0500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3163
    Cell Significance Index: -3.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3169
    Cell Significance Index: -3.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3179
    Cell Significance Index: -4.6500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3201
    Cell Significance Index: -3.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV26.1 is a member of the T cell receptor alpha (TRAV) gene family, which is responsible for encoding the variable regions of the T cell receptor alpha chain. This gene is characterized by its high degree of polymorphism, with multiple alleles and variants exhibiting distinct expression patterns. TRAV26.1 is specifically expressed in a subset of hematopoietic progenitor cells, including granulocyte-monocyte progenitors and early T lineage precursors. The expression of TRAV26.1 is also restricted to alpha-beta cytotoxic T cells, highlighting its role in the development of these cells. **Pathways and Functions:** TRAV26.1 plays a critical role in the adaptive immune response, particularly in response to bacterial infections. The gene is involved in the activation of T cells, which is essential for the elimination of pathogens. The expression of TRAV26.1 is also linked to the development of alpha-beta cytotoxic T cells, which are crucial for the elimination of virus-infected cells and tumor cells. The gene's involvement in the T cell receptor complex highlights its role in the recognition of antigens and the activation of T cells. The TRAV26.1 gene is also involved in the regulation of gene expression, particularly in the context of the adaptive immune response. The gene's expression is tightly regulated by various transcription factors, including T cell receptor alpha and T cell receptor beta chains. The regulation of TRAV26.1 expression is essential for the proper development and function of alpha-beta cytotoxic T cells. **Clinical Significance:** The TRAV26.1 gene's role in the adaptive immune response has significant clinical implications. The gene's involvement in the development of alpha-beta cytotoxic T cells highlights its potential as a target for immunotherapeutic interventions. The gene's expression in various hematopoietic progenitor cells also highlights its potential as a biomarker for the diagnosis and monitoring of immune-related disorders. Furthermore, the TRAV26.1 gene's involvement in the regulation of gene expression highlights its potential as a therapeutic target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. The gene's expression in various hematopoietic progenitor cells also highlights its potential as a biomarker for the diagnosis and monitoring of hematological disorders. In conclusion, the TRAV26.1 gene is a critical component of the adaptive immune response, playing a key role in the recognition of antigens and the activation of T cells. The gene's involvement in the development of alpha-beta cytotoxic T cells highlights its potential as a target for immunotherapeutic interventions, while its expression in various hematopoietic progenitor cells highlights its potential as a biomarker for the diagnosis and monitoring of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.