IGLV7 43 | ENSG00000211652 | NCBI 28776

Details for: IGLV7 43

Gene ID: 28776

Symbol: IGLV7 43

Ensembl ID: ENSG00000211652

Description: immunoglobulin lambda variable 7-43

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162,083
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.69
Marker Score: 8,279
Cell Name: microglial cell (CL0000129)
Fold Change: 3.76
Marker Score: 6,845
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.16
Marker Score: 3,177
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.01
Marker Score: 2,000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1,175
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 875
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 860
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 491
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,692
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,821
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 801
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,814
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.01
Marker Score: 465
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,057
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 513
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 466
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 377
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,349
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.89
Marker Score: 1,444
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 466
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.67
Marker Score: 261
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.66
Marker Score: 441
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.63
Marker Score: 503
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 150
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 281
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.46
Marker Score: 595
Cell Name: Unknown (CL0000003)
Fold Change: 0.46
Marker Score: 1,418
Cell Name: leukocyte (CL0000738)
Fold Change: 0.44
Marker Score: 253
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.41
Marker Score: 314
Cell Name: mast cell (CL0000097)
Fold Change: 0.37
Marker Score: 216
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.37
Marker Score: 117
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.34
Marker Score: 346
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.3
Marker Score: 329
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.27
Marker Score: 231
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.22
Marker Score: 125
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.18
Marker Score: 752
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.18
Marker Score: 288
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.17
Marker Score: 392
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: plasmablast (CL0000980)
Fold Change: 0.15
Marker Score: 202
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.14
Marker Score: 60
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.13
Marker Score: 322
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.12
Marker Score: 82
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.12
Marker Score: 75
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.11
Marker Score: 52
Cell Name: naive B cell (CL0000788)
Fold Change: 0.11
Marker Score: 95
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.1
Marker Score: 66
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.09
Marker Score: 226
Cell Name: neutrophil (CL0000775)
Fold Change: 0.09
Marker Score: 53
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.08
Marker Score: 20
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.08
Marker Score: 19
Cell Name: plasma cell (CL0000786)
Fold Change: 0.08
Marker Score: 92
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.08
Marker Score: 97
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.08
Marker Score: 95
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.08
Marker Score: 19
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.07
Marker Score: 19
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.07
Marker Score: 26
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.07
Marker Score: 38
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.07
Marker Score: 66
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.07
Marker Score: 48
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.07
Marker Score: 31
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.07
Marker Score: 19
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 137
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.06
Marker Score: 38
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: immature B cell (CL0000816)
Fold Change: 0.06
Marker Score: 41
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.06
Marker Score: 16
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.06
Marker Score: 51
Cell Name: platelet (CL0000233)
Fold Change: 0.06
Marker Score: 27
Cell Name: B cell (CL0000236)
Fold Change: 0.06
Marker Score: 56
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.06
Marker Score: 31
Cell Name: blood cell (CL0000081)
Fold Change: 0.06
Marker Score: 650
Cell Name: memory B cell (CL0000787)
Fold Change: 0.06
Marker Score: 42
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.06
Marker Score: 291
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.05
Marker Score: 53
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.05
Marker Score: 46
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.05
Marker Score: 22
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.05
Marker Score: 82
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 35
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.05
Marker Score: 18
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.05
Marker Score: 27
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.05
Marker Score: 12
Cell Name: memory T cell (CL0000813)
Fold Change: 0.05
Marker Score: 20
Cell Name: granulocyte (CL0000094)
Fold Change: 0.04
Marker Score: 20
Cell Name: monocyte (CL0000576)
Fold Change: 0.04
Marker Score: 57
Cell Name: stromal cell (CL0000499)
Fold Change: 0.04
Marker Score: 51
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.04
Marker Score: 12
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.04
Marker Score: 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin lambda variable**: IGLV7 43 is a part of the immunoglobulin lambda variable region, which is crucial for the specificity and binding of antibodies to antigens. 2. **Variable region**: The variable region of IGLV7 43 is responsible for the diversity of the immune response, allowing for the recognition and targeting of specific pathogens. 3. **Significant expression in various cell types**: IGLV7 43 is expressed in a wide range of cell types, including those involved in the immune system, such as microglial cells and B cells, as well as cells in the central nervous system, such as oligodendrocyte precursor cells. 4. **Involvement in parasitic infections**: IGLV7 43 is specifically involved in the regulation of immune responses against parasitic infections, such as Leishmania parasite infection. **Pathways and Functions:** 1. **Adaptive immune response**: IGLV7 43 is involved in the adaptive immune response, which is a specific and targeted response to pathogens. 2. **Anti-inflammatory responses**: IGLV7 43 regulates anti-inflammatory responses, which are crucial for preventing excessive inflammation and tissue damage. 3. **Complement cascade regulation**: IGLV7 43 is involved in the regulation of the complement cascade, which is a critical component of the innate immune response. 4. **Signaling by the B cell receptor (BCR)**: IGLV7 43 is involved in signaling by the B cell receptor (BCR), which is essential for the activation of B cells and the production of antibodies. 5. **Phagocytosis and immune response regulation**: IGLV7 43 regulates phagocytosis and immune response, which are critical for the clearance of pathogens and the prevention of tissue damage. **Clinical Significance:** 1. **Infectious diseases**: Dysregulation of IGLV7 43 may contribute to the development of infectious diseases, such as Leishmania parasite infection. 2. **Autoimmune disorders**: Alterations in IGLV7 43 expression may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Cancer**: IGLV7 43 may play a role in the regulation of immune responses against cancer cells, potentially contributing to cancer development or progression. 4. **Potential therapeutics**: Understanding the role of IGLV7 43 in immune responses and parasitic infections may lead to the development of new therapeutics for these diseases. In conclusion, IGLV7 43 is a complex gene that plays a critical role in the regulation of immune responses, particularly in the context of parasitic infections. Further research is needed to fully understand the mechanisms by which IGLV7 43 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.