Details for: IGLV5 48

Gene ID: 28780

Symbol: IGLV5 48

Ensembl ID: ENSG00000211647

Description: immunoglobulin lambda variable 5-48 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0737
    Cell Significance Index: 1.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0823
    Cell Significance Index: -3.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1513
    Cell Significance Index: -30.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2270
    Cell Significance Index: -13.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2727
    Cell Significance Index: -7.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3413
    Cell Significance Index: -8.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3697
    Cell Significance Index: -9.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4542
    Cell Significance Index: -12.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6056
    Cell Significance Index: -11.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6536
    Cell Significance Index: -12.0800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.6827
    Cell Significance Index: -7.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6984
    Cell Significance Index: -10.1400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.7062
    Cell Significance Index: -7.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.7144
    Cell Significance Index: -11.5700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7381
    Cell Significance Index: -8.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.8073
    Cell Significance Index: -11.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.8563
    Cell Significance Index: -9.6500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8699
    Cell Significance Index: -11.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.8776
    Cell Significance Index: -12.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.9399
    Cell Significance Index: -11.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9438
    Cell Significance Index: -11.9100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9478
    Cell Significance Index: -11.8400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.9549
    Cell Significance Index: -11.4200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.9579
    Cell Significance Index: -9.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.9721
    Cell Significance Index: -12.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9747
    Cell Significance Index: -22.5200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -1.0310
    Cell Significance Index: -12.1300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -1.0315
    Cell Significance Index: -11.8700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.0468
    Cell Significance Index: -11.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.0693
    Cell Significance Index: -7.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -1.0758
    Cell Significance Index: -13.9200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -1.0797
    Cell Significance Index: -12.7600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -1.0867
    Cell Significance Index: -9.2600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.1014
    Cell Significance Index: -9.8400
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -1.1223
    Cell Significance Index: -9.8600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -1.1510
    Cell Significance Index: -9.4500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -1.1750
    Cell Significance Index: -11.8700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -1.1961
    Cell Significance Index: -13.8900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -1.2128
    Cell Significance Index: -15.3600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -1.2648
    Cell Significance Index: -9.4100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.2749
    Cell Significance Index: -11.8700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -1.2927
    Cell Significance Index: -11.5300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.3123
    Cell Significance Index: -13.9400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -1.3145
    Cell Significance Index: -13.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -1.3203
    Cell Significance Index: -12.6900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.3251
    Cell Significance Index: -11.5900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -1.3360
    Cell Significance Index: -12.0600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -1.3535
    Cell Significance Index: -12.0500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -1.3662
    Cell Significance Index: -12.7800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.3722
    Cell Significance Index: -11.5800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -1.3741
    Cell Significance Index: -14.7800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -1.3771
    Cell Significance Index: -13.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.3899
    Cell Significance Index: -16.4100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -1.3919
    Cell Significance Index: -11.4900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -1.3974
    Cell Significance Index: -11.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.4137
    Cell Significance Index: -24.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -1.4284
    Cell Significance Index: -15.4000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -1.4525
    Cell Significance Index: -13.0900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.4626
    Cell Significance Index: -15.4000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -1.4640
    Cell Significance Index: -13.8800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -1.4659
    Cell Significance Index: -11.8700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -1.4754
    Cell Significance Index: -13.9300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -1.5031
    Cell Significance Index: -13.9500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -1.5120
    Cell Significance Index: -13.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.5285
    Cell Significance Index: -15.4000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.5476
    Cell Significance Index: -16.4700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -1.5476
    Cell Significance Index: -12.0400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.5542
    Cell Significance Index: -16.4800
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -1.5694
    Cell Significance Index: -12.0500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -1.5959
    Cell Significance Index: -16.5300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -1.6299
    Cell Significance Index: -11.4700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -1.6318
    Cell Significance Index: -15.3500
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -1.6344
    Cell Significance Index: -11.5200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -1.6494
    Cell Significance Index: -16.7300
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -1.6501
    Cell Significance Index: -13.9100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -1.6619
    Cell Significance Index: -14.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.7008
    Cell Significance Index: -22.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.7052
    Cell Significance Index: -22.4400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -1.7239
    Cell Significance Index: -27.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.7251
    Cell Significance Index: -26.2000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -1.7365
    Cell Significance Index: -15.9500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.7381
    Cell Significance Index: -22.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.7437
    Cell Significance Index: -22.4000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -1.7529
    Cell Significance Index: -12.7400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.7543
    Cell Significance Index: -16.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.7630
    Cell Significance Index: -21.6700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -1.7661
    Cell Significance Index: -14.7600
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -1.7670
    Cell Significance Index: -15.4000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.7695
    Cell Significance Index: -20.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.7900
    Cell Significance Index: -26.0900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -1.8043
    Cell Significance Index: -16.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.8129
    Cell Significance Index: -25.7600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -1.8144
    Cell Significance Index: -13.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.8329
    Cell Significance Index: -20.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.8358
    Cell Significance Index: -20.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.8456
    Cell Significance Index: -21.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -1.8727
    Cell Significance Index: -16.5000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -1.8921
    Cell Significance Index: -16.5400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -1.9233
    Cell Significance Index: -26.1700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -1.9276
    Cell Significance Index: -22.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV5-48 is a member of the immunoglobulin lambda (λ) family, which consists of genes that encode the light chains of immunoglobulins. Unlike functional immunoglobulin genes, IGLV5-48 does not encode a functional light chain and is therefore non-functional. The gene is located on chromosome 22, and its expression is widespread, with significant levels detected in various immune cells. Notably, IGLV5-48 is expressed in cells that are not typically associated with the immune system, such as goblet cells and absorptive cells. **Pathways and Functions:** The pathways and functions associated with IGLV5-48 are not well-defined, but its expression in immune cells suggests that it may play a role in the regulation of immune responses. The gene is involved in the adaptive immune response, which is a complex process that involves the activation of immune cells, such as T cells and B cells, in response to pathogens or foreign substances. IGLV5-48 may contribute to the development and function of immune cells, potentially by influencing the expression of other genes involved in immune responses. **Clinical Significance:** Despite its non-functional nature, IGLV5-48 has been identified as a significantly expressed gene in various types of cancer, including leukemia and lymphoma. This suggests that IGLV5-48 may play a role in the development or progression of these diseases. Furthermore, the gene's expression in normal tissues, such as the fallopian tube and absorptive cells, raises questions about its potential role in the regulation of immune responses in these tissues. In conclusion, IGLV5-48 is a non-functional immunoglobulin lambda variable gene that is significantly expressed in a wide range of immune cells. Its expression patterns and potential functional implications warrant further investigation into its role in the adaptive immune response and potential clinical significance. Further studies are needed to fully understand the significance of IGLV5-48 and its potential applications in immunology and cancer research. **Recommendations for Future Research:** 1. Investigate the functional implications of IGLV5-48 in immune cells, including its potential role in regulating immune responses. 2. Examine the expression patterns of IGLV5-48 in various types of cancer, including leukemia and lymphoma, to determine its potential role in disease development or progression. 3. Explore the potential therapeutic applications of IGLV5-48, including its use as a biomarker or target for cancer therapy. 4. Investigate the expression of IGLV5-48 in normal tissues, such as the fallopian tube and absorptive cells, to determine its potential role in regulating immune responses in these tissues.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.