Details for: IGLV5 48

Gene ID: 28780

Symbol: IGLV5 48

Ensembl ID: ENSG00000211647

Description: immunoglobulin lambda variable 5-48 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.42
    Marker Score: 4,166
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,518
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,803
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,568
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.23
    Marker Score: 705
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,649
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,714
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,803
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,340
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.88
    Marker Score: 442
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.78
    Marker Score: 1,008
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,192
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.57
    Marker Score: 641
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 331
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.46
    Marker Score: 442
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 324
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.28
    Marker Score: 375
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.25
    Marker Score: 255
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 134
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 703
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.08
    Marker Score: 100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 123
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.05
    Marker Score: 129
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 82
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.02
    Marker Score: 210
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 34
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 29
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 42
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 26
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 20

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV5-48 is a member of the immunoglobulin lambda (λ) family, which consists of genes that encode the light chains of immunoglobulins. Unlike functional immunoglobulin genes, IGLV5-48 does not encode a functional light chain and is therefore non-functional. The gene is located on chromosome 22, and its expression is widespread, with significant levels detected in various immune cells. Notably, IGLV5-48 is expressed in cells that are not typically associated with the immune system, such as goblet cells and absorptive cells. **Pathways and Functions:** The pathways and functions associated with IGLV5-48 are not well-defined, but its expression in immune cells suggests that it may play a role in the regulation of immune responses. The gene is involved in the adaptive immune response, which is a complex process that involves the activation of immune cells, such as T cells and B cells, in response to pathogens or foreign substances. IGLV5-48 may contribute to the development and function of immune cells, potentially by influencing the expression of other genes involved in immune responses. **Clinical Significance:** Despite its non-functional nature, IGLV5-48 has been identified as a significantly expressed gene in various types of cancer, including leukemia and lymphoma. This suggests that IGLV5-48 may play a role in the development or progression of these diseases. Furthermore, the gene's expression in normal tissues, such as the fallopian tube and absorptive cells, raises questions about its potential role in the regulation of immune responses in these tissues. In conclusion, IGLV5-48 is a non-functional immunoglobulin lambda variable gene that is significantly expressed in a wide range of immune cells. Its expression patterns and potential functional implications warrant further investigation into its role in the adaptive immune response and potential clinical significance. Further studies are needed to fully understand the significance of IGLV5-48 and its potential applications in immunology and cancer research. **Recommendations for Future Research:** 1. Investigate the functional implications of IGLV5-48 in immune cells, including its potential role in regulating immune responses. 2. Examine the expression patterns of IGLV5-48 in various types of cancer, including leukemia and lymphoma, to determine its potential role in disease development or progression. 3. Explore the potential therapeutic applications of IGLV5-48, including its use as a biomarker or target for cancer therapy. 4. Investigate the expression of IGLV5-48 in normal tissues, such as the fallopian tube and absorptive cells, to determine its potential role in regulating immune responses in these tissues.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.