Details for: IGLV2 18

Gene ID: 28814

Symbol: IGLV2 18

Ensembl ID: ENSG00000211664

Description: immunoglobulin lambda variable 2-18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0284
    Cell Significance Index: 0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0152
    Cell Significance Index: -0.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0644
    Cell Significance Index: -1.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0815
    Cell Significance Index: -0.9900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1108
    Cell Significance Index: -1.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1365
    Cell Significance Index: -3.6500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1649
    Cell Significance Index: -1.6900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1675
    Cell Significance Index: -1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1759
    Cell Significance Index: -8.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1849
    Cell Significance Index: -4.7100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1851
    Cell Significance Index: -2.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1892
    Cell Significance Index: -3.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2034
    Cell Significance Index: -3.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2035
    Cell Significance Index: -2.9600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2098
    Cell Significance Index: -2.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2130
    Cell Significance Index: -3.4500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2207
    Cell Significance Index: -1.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2375
    Cell Significance Index: -4.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2470
    Cell Significance Index: -6.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2567
    Cell Significance Index: -3.5600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2672
    Cell Significance Index: -3.0800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2737
    Cell Significance Index: -2.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2754
    Cell Significance Index: -3.4900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2774
    Cell Significance Index: -2.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2862
    Cell Significance Index: -4.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2927
    Cell Significance Index: -3.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3013
    Cell Significance Index: -3.9400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3022
    Cell Significance Index: -3.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3068
    Cell Significance Index: -3.9700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3106
    Cell Significance Index: -4.2600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3124
    Cell Significance Index: -3.4900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3131
    Cell Significance Index: -3.4300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3154
    Cell Significance Index: -3.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3161
    Cell Significance Index: -4.2000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3167
    Cell Significance Index: -3.3700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3242
    Cell Significance Index: -4.0500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3363
    Cell Significance Index: -3.8700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3410
    Cell Significance Index: -3.9600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3442
    Cell Significance Index: -4.0500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3444
    Cell Significance Index: -3.7800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3470
    Cell Significance Index: -3.7900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3499
    Cell Significance Index: -4.1400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3507
    Cell Significance Index: -3.8100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3514
    Cell Significance Index: -3.8900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3573
    Cell Significance Index: -3.4300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3576
    Cell Significance Index: -4.0300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3603
    Cell Significance Index: -3.8500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3614
    Cell Significance Index: -3.0800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.3664
    Cell Significance Index: -3.4000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3692
    Cell Significance Index: -3.6900
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.3706
    Cell Significance Index: -3.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3734
    Cell Significance Index: -4.9000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3736
    Cell Significance Index: -4.0700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3751
    Cell Significance Index: -3.4300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3752
    Cell Significance Index: -3.8600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3757
    Cell Significance Index: -4.4400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3763
    Cell Significance Index: -4.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3782
    Cell Significance Index: -3.9900
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.3806
    Cell Significance Index: -3.5100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.3819
    Cell Significance Index: -3.2900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3834
    Cell Significance Index: -3.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3838
    Cell Significance Index: -4.6300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3879
    Cell Significance Index: -4.0200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3891
    Cell Significance Index: -4.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3910
    Cell Significance Index: -3.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3922
    Cell Significance Index: -4.1300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3922
    Cell Significance Index: -4.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3925
    Cell Significance Index: -3.8400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3930
    Cell Significance Index: -3.6900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3931
    Cell Significance Index: -3.6600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3963
    Cell Significance Index: -4.7100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3966
    Cell Significance Index: -4.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3979
    Cell Significance Index: -5.8000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3985
    Cell Significance Index: -4.2400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.3994
    Cell Significance Index: -3.6900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4050
    Cell Significance Index: -3.9600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4061
    Cell Significance Index: -3.6600
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.4075
    Cell Significance Index: -3.5800
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.4118
    Cell Significance Index: -4.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4119
    Cell Significance Index: -5.4200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4129
    Cell Significance Index: -5.3900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4139
    Cell Significance Index: -4.1700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4139
    Cell Significance Index: -4.4500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4157
    Cell Significance Index: -4.2000
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.4175
    Cell Significance Index: -3.7400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4213
    Cell Significance Index: -3.5600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4232
    Cell Significance Index: -3.8200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4240
    Cell Significance Index: -3.7800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4247
    Cell Significance Index: -4.1400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4262
    Cell Significance Index: -4.7200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4280
    Cell Significance Index: -4.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4362
    Cell Significance Index: -5.1500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4369
    Cell Significance Index: -4.5800
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.4375
    Cell Significance Index: -4.0600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.4402
    Cell Significance Index: -3.3800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.4411
    Cell Significance Index: -4.0200
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.4422
    Cell Significance Index: -4.7200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4426
    Cell Significance Index: -5.2300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.4436
    Cell Significance Index: -3.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene location:** IGLV2 18 is located on the X chromosome (Ensembl ID: ENSG00000211664). 2. **Gene product:** The IGLV2 18 gene encodes for a lambda light chain variable region, which is a critical component of antibodies. 3. **Significant expression:** This gene is expressed in a wide range of cell types, including T cells, granulocytes, goblet cells, and others, suggesting its involvement in various immune and non-immune functions. 4. **X-linked:** As an X-linked gene, IGLV2 18 is subject to X-linked inheritance patterns, which can lead to sex-linked immune deficiencies. **Pathways and Functions:** 1. **Adaptive immune response:** The IGLV2 18 gene is involved in the adaptive immune response, where it contributes to the production of antibodies, which are essential for recognizing and eliminating pathogens. 2. **Immunoglobulin production:** IGLV2 18 plays a role in the production of immunoglobulins, which are proteins that recognize and bind to specific antigens. 3. **Immunoglobulin complex formation:** The lambda light chain encoded by IGLV2 18 is a crucial component of immunoglobulin complexes, which are formed through the association of light and heavy chains. 4. **Cell signaling:** The IGLV2 18 gene may also be involved in cell signaling pathways, where it modulates immune responses and cell interactions. **Clinical Significance:** 1. **Immune deficiencies:** Mutations in the IGLV2 18 gene can lead to X-linked agammaglobulinemia (XLA), a rare immunodeficiency disorder characterized by impaired antibody production. 2. **Autoimmune diseases:** Alterations in the IGLV2 18 gene may contribute to autoimmune diseases, such as rheumatoid arthritis, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** The IGLV2 18 gene may be involved in cancer development, particularly in cancers that involve immune evasion, such as lymphomas and leukemias. 4. **Transplantation:** The IGLV2 18 gene may be important in transplantation medicine, where it can influence the immune response to transplanted organs. In conclusion, the IGLV2 18 gene plays a vital role in the adaptive immune response, immunoglobulin production, and cell signaling. Its clinical significance is multifaceted, with implications for immune deficiencies, autoimmune diseases, cancer, and transplantation medicine. Further research is necessary to fully elucidate the functions and pathologies associated with the IGLV2 18 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.