IGKV3D 20 | ENSG00000211625 | NCBI 28874

Details for: IGKV3D 20

Gene ID: 28874

Symbol: IGKV3D 20

Ensembl ID: ENSG00000211625

Description: immunoglobulin kappa variable 3D-20

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1758
Cell Significance Index: 2.7200
Cell Name: lung pericyte (CL0009089)
Fold Change: -0.0010
Cell Significance Index: -0.0100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0369
Cell Significance Index: -3.7700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0434
Cell Significance Index: -2.0200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1114
Cell Significance Index: -2.9800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1266
Cell Significance Index: -3.1600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1399
Cell Significance Index: -1.8300
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1449
Cell Significance Index: -1.4800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1513
Cell Significance Index: -3.6700
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1552
Cell Significance Index: -1.7400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1574
Cell Significance Index: -4.0100
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.1648
Cell Significance Index: -1.3600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1744
Cell Significance Index: -3.4100
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1802
Cell Significance Index: -1.2000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2083
Cell Significance Index: -3.8500
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.2128
Cell Significance Index: -1.7100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2145
Cell Significance Index: -2.5400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2273
Cell Significance Index: -3.8900
Cell Name: monocyte (CL0000576)
Fold Change: -0.2303
Cell Significance Index: -2.6500
Cell Name: blood cell (CL0000081)
Fold Change: -0.2311
Cell Significance Index: -1.9700
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2385
Cell Significance Index: -2.9500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2470
Cell Significance Index: -4.0000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2656
Cell Significance Index: -3.1300
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2691
Cell Significance Index: -3.6900
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2767
Cell Significance Index: -3.5800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2783
Cell Significance Index: -4.0400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2789
Cell Significance Index: -3.1700
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2819
Cell Significance Index: -3.5700
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.2837
Cell Significance Index: -3.0500
Cell Name: acinar cell (CL0000622)
Fold Change: -0.2882
Cell Significance Index: -3.6200
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2893
Cell Significance Index: -3.7100
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.2898
Cell Significance Index: -2.6500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2918
Cell Significance Index: -3.2600
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.2965
Cell Significance Index: -3.1500
Cell Name: granulocyte (CL0000094)
Fold Change: -0.2993
Cell Significance Index: -3.6100
Cell Name: alveolar type 1 fibroblast cell (CL4028004)
Fold Change: -0.3005
Cell Significance Index: -3.1800
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3021
Cell Significance Index: -3.5700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3053
Cell Significance Index: -3.3800
Cell Name: paneth cell (CL0000510)
Fold Change: -0.3064
Cell Significance Index: -3.1700
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.3138
Cell Significance Index: -3.9700
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.3183
Cell Significance Index: -3.1400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3209
Cell Significance Index: -3.0800
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.3220
Cell Significance Index: -3.4900
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.3243
Cell Significance Index: -1.8100
Cell Name: glial cell (CL0000125)
Fold Change: -0.3245
Cell Significance Index: -3.5600
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.3251
Cell Significance Index: -3.5900
Cell Name: myelocyte (CL0002193)
Fold Change: -0.3297
Cell Significance Index: -3.5200
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3305
Cell Significance Index: -3.0700
Cell Name: MHC-II-positive classical monocyte (CL0002470)
Fold Change: -0.3323
Cell Significance Index: -1.7600
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3410
Cell Significance Index: -3.9600
Cell Name: podocyte (CL0000653)
Fold Change: -0.3461
Cell Significance Index: -3.9700
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.3482
Cell Significance Index: -3.0000
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3487
Cell Significance Index: -3.5400
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3576
Cell Significance Index: -3.1900
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3650
Cell Significance Index: -6.2000
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: -0.3650
Cell Significance Index: -3.6200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.3664
Cell Significance Index: -3.9500
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.3691
Cell Significance Index: -3.8900
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3729
Cell Significance Index: -4.7900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.3770
Cell Significance Index: -5.0100
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.3778
Cell Significance Index: -3.9700
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.3798
Cell Significance Index: -2.9200
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.3828
Cell Significance Index: -3.4200
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3833
Cell Significance Index: -5.0300
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.3847
Cell Significance Index: -3.8400
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.3873
Cell Significance Index: -4.0600
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.3884
Cell Significance Index: -4.4700
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.3919
Cell Significance Index: -3.7000
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.3931
Cell Significance Index: -4.0100
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.3933
Cell Significance Index: -3.5500
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.3936
Cell Significance Index: -2.7700
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.3940
Cell Significance Index: -4.5700
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.3968
Cell Significance Index: -3.8800
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.3971
Cell Significance Index: -3.0300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3980
Cell Significance Index: -11.4100
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.3990
Cell Significance Index: -3.7200
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.4023
Cell Significance Index: -3.4000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.4052
Cell Significance Index: -3.9500
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.4064
Cell Significance Index: -3.5600
Cell Name: mast cell (CL0000097)
Fold Change: -0.4065
Cell Significance Index: -5.3500
Cell Name: T cell (CL0000084)
Fold Change: -0.4074
Cell Significance Index: -4.8100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4079
Cell Significance Index: -4.3400
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.4090
Cell Significance Index: -3.8100
Cell Name: naive T cell (CL0000898)
Fold Change: -0.4128
Cell Significance Index: -3.7500
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4162
Cell Significance Index: -4.6900
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.4166
Cell Significance Index: -3.6600
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4198
Cell Significance Index: -4.6500
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.4198
Cell Significance Index: -3.9800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.4269
Cell Significance Index: -4.5000
Cell Name: secretory cell (CL0000151)
Fold Change: -0.4297
Cell Significance Index: -2.9800
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4322
Cell Significance Index: -4.0900
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.4362
Cell Significance Index: -4.0800
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.4366
Cell Significance Index: -4.0100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4371
Cell Significance Index: -5.4600
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.4405
Cell Significance Index: -3.9700
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.4427
Cell Significance Index: -3.5900
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.4460
Cell Significance Index: -3.6600
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4466
Cell Significance Index: -5.8300
Cell Name: platelet (CL0000233)
Fold Change: -0.4491
Cell Significance Index: -4.6200
Cell Name: B cell (CL0000236)
Fold Change: -0.4519
Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV3D20 is a member of the immunoglobulin superfamily, which comprises genes that encode for antibody light chains. The kappa light chain is a crucial component of antibodies, responsible for the specificity and diversity of the immune response. IGKV3D20 is characterized by its high expression levels in various cell types, including T cells, granulocytes, and goblet cells. This widespread expression suggests that IGKV3D20 plays a critical role in the regulation of immune responses at multiple levels. **Pathways and Functions** IGKV3D20 is involved in various immune pathways, including: 1. **Adaptive Immune Response**: IGKV3D20 is expressed in T cells, which are central to the adaptive immune response. The expression of IGKV3D20 in T cells suggests that it plays a role in the regulation of T cell activation and immune responses to pathogens. 2. **Complement Cascade**: IGKV3D20 is involved in the regulation of complement cascades, which are critical for the elimination of pathogens from the body. The expression of IGKV3D20 in cells that express complement regulatory proteins suggests that it plays a role in the regulation of complement activation. 3. **Antigen Recognition**: IGKV3D20 is expressed in B cells, which are responsible for the recognition of antigens. The expression of IGKV3D20 in B cells suggests that it plays a role in the regulation of B cell receptor signaling and the recognition of antigens. 4. **Leishmania Infection**: IGKV3D20 is expressed in cells that are involved in the response to Leishmania parasites, which suggests that it plays a role in the regulation of immune responses to these pathogens. **Clinical Significance** The expression of IGKV3D20 has significant clinical implications, particularly in the context of Leishmania infections. Leishmania parasites are responsible for a range of diseases, including visceral leishmaniasis and cutaneous leishmaniasis. The expression of IGKV3D20 in cells that are involved in the response to Leishmania parasites suggests that it plays a critical role in the regulation of immune responses to these pathogens. Furthermore, the expression of IGKV3D20 has been associated with various immune-related disorders, including autoimmune diseases and cancer. The dysregulation of IGKV3D20 expression has been implicated in the pathogenesis of these disorders, suggesting that it may be a potential therapeutic target. In conclusion, the immunoglobulin kappa variable 3D-20 gene plays a critical role in the regulation of immune responses, including the adaptive immune response, complement cascade, and antigen recognition. Its expression in various cell types and its involvement in the response to Leishmania parasites make it a significant player in the immune system. Further research is needed to fully understand the role of IGKV3D20 in the immune system and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.