Details for: IGKV2 29

Gene ID: 28920

Symbol: IGKV2 29

Ensembl ID: ENSG00000253998

Description: immunoglobulin kappa variable 2-29

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.68
    Marker Score: 2,099
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.45
    Marker Score: 729
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.42
    Marker Score: 257
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.39
    Marker Score: 867
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.35
    Marker Score: 449
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 155
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.18
    Marker Score: 218
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.16
    Marker Score: 134
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 104
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.13
    Marker Score: 178
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.12
    Marker Score: 89
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 168
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.08
    Marker Score: 318
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.07
    Marker Score: 167
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 143
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 619
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.05
    Marker Score: 140
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 343

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-29 is a member of the immunoglobulin kappa (IgK) family, which comprises a diverse array of genes responsible for encoding the variable regions of kappa light chains. The IgK family is a crucial component of the adaptive immune response, participating in the production of antibodies and the activation of immune cells. IGKV2-29 is characterized by its specific expression in hematopoietic cells, including granulocyte-monocyte progenitor cells, early T lineage precursors, and neutrophil progenitors. This expression pattern suggests that IGKV2-29 plays a role in the development and maturation of these cells, potentially influencing their ability to recognize and respond to pathogens. **Pathways and Functions:** IGKV2-29 is involved in several key pathways, including the adaptive immune response, extracellular region, extracellular space, immune response, immunoglobulin complex, immunoglobulin production, and plasma membrane. The adaptive immune response is a critical process by which the immune system recognizes and responds to specific pathogens. IGKV2-29 is likely to participate in this process by contributing to the production of antibodies and the activation of immune cells. The expression of IGKV2-29 in hematopoietic cells also suggests that it may play a role in the development and maturation of immune cells, potentially influencing their ability to recognize and respond to pathogens. **Functions:** IGKV2-29 is likely to function as a component of the immunoglobulin complex, which is essential for the recognition and binding of pathogens. The expression of IGKV2-29 in hematopoietic cells also suggests that it may participate in the production of antibodies, which are critical for the clearance of pathogens from the body. Furthermore, IGKV2-29 may play a role in the activation of immune cells, such as T cells and natural killer cells, which are essential for the elimination of pathogens. **Clinical Significance:** The clinical significance of IGKV2-29 is an area of active research. Dysregulation of IGKV2-29 expression has been linked to various immunological disorders, including autoimmune diseases and cancer. For example, alterations in IGKV2-29 expression have been observed in patients with multiple sclerosis, a disease characterized by inflammation and demyelination in the central nervous system. Additionally, IGKV2-29 may play a role in the development of cancer, as altered expression of this gene has been observed in certain types of leukemia and lymphoma. Further research is needed to fully elucidate the clinical significance of IGKV2-29 and its potential as a therapeutic target for immunological disorders. In conclusion, IGKV2-29 is a critical component of the adaptive immune response, playing a role in the production of antibodies and the activation of immune cells. The expression of IGKV2-29 in hematopoietic cells highlights its involvement in the development and maturation of immune cells. Further research is needed to fully elucidate the clinical significance of IGKV2-29 and its potential as a therapeutic target for immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.