Details for: IGKV2 29

Gene ID: 28920

Symbol: IGKV2 29

Ensembl ID: ENSG00000253998

Description: immunoglobulin kappa variable 2-29

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 4.1544
    Cell Significance Index: 46.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3785
    Cell Significance Index: 33.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9570
    Cell Significance Index: 13.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.5108
    Cell Significance Index: 6.6800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3125
    Cell Significance Index: 3.8700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2971
    Cell Significance Index: 4.3300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1782
    Cell Significance Index: 2.1500
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.1086
    Cell Significance Index: 0.5000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0157
    Cell Significance Index: -0.7300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0180
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0198
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0274
    Cell Significance Index: -0.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0392
    Cell Significance Index: -1.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0445
    Cell Significance Index: -0.8700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0467
    Cell Significance Index: -0.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0498
    Cell Significance Index: -1.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0638
    Cell Significance Index: -0.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0716
    Cell Significance Index: -0.8000
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0749
    Cell Significance Index: -0.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0777
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0780
    Cell Significance Index: -0.9800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0823
    Cell Significance Index: -0.8400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0833
    Cell Significance Index: -0.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0846
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0862
    Cell Significance Index: -0.9000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0878
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0884
    Cell Significance Index: -0.7000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0885
    Cell Significance Index: -1.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0897
    Cell Significance Index: -1.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0963
    Cell Significance Index: -1.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0974
    Cell Significance Index: -1.2600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0976
    Cell Significance Index: -0.6400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1035
    Cell Significance Index: -1.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1035
    Cell Significance Index: -1.7700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1109
    Cell Significance Index: -1.3400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1115
    Cell Significance Index: -1.0200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1118
    Cell Significance Index: -1.2700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1135
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1138
    Cell Significance Index: -1.3900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1147
    Cell Significance Index: -1.2200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1155
    Cell Significance Index: -1.4200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1159
    Cell Significance Index: -1.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1194
    Cell Significance Index: -1.2200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1198
    Cell Significance Index: -1.2800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1219
    Cell Significance Index: -1.0800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1219
    Cell Significance Index: -1.4500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1226
    Cell Significance Index: -1.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1257
    Cell Significance Index: -1.6700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1262
    Cell Significance Index: -1.2500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1283
    Cell Significance Index: -1.3800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1297
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1299
    Cell Significance Index: -1.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1313
    Cell Significance Index: -1.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1320
    Cell Significance Index: -2.4400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1347
    Cell Significance Index: -1.4300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1356
    Cell Significance Index: -1.7800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1358
    Cell Significance Index: -1.4700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1364
    Cell Significance Index: -1.4900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1382
    Cell Significance Index: -1.7800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1390
    Cell Significance Index: -1.5400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1412
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1422
    Cell Significance Index: -1.5000
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1446
    Cell Significance Index: -1.2600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1449
    Cell Significance Index: -1.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1451
    Cell Significance Index: -1.6700
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1455
    Cell Significance Index: -1.3500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1456
    Cell Significance Index: -1.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1466
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1467
    Cell Significance Index: -1.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1471
    Cell Significance Index: -1.9200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1487
    Cell Significance Index: -1.4700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1499
    Cell Significance Index: -1.7800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1515
    Cell Significance Index: -1.7600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1518
    Cell Significance Index: -1.5500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1531
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1553
    Cell Significance Index: -1.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1555
    Cell Significance Index: -1.3700
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1556
    Cell Significance Index: -1.4500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1575
    Cell Significance Index: -1.4900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1579
    Cell Significance Index: -1.3700
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1587
    Cell Significance Index: -1.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1604
    Cell Significance Index: -2.0600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1607
    Cell Significance Index: -1.4600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1631
    Cell Significance Index: -1.3900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1642
    Cell Significance Index: -1.9400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1651
    Cell Significance Index: -1.5100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1660
    Cell Significance Index: -1.9600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1672
    Cell Significance Index: -1.6300
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1675
    Cell Significance Index: -0.8400
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1684
    Cell Significance Index: -1.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1684
    Cell Significance Index: -1.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1697
    Cell Significance Index: -1.7600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1699
    Cell Significance Index: -1.5100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1709
    Cell Significance Index: -1.4700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1714
    Cell Significance Index: -1.3700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1726
    Cell Significance Index: -1.8300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1733
    Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-29 is a member of the immunoglobulin kappa (IgK) family, which comprises a diverse array of genes responsible for encoding the variable regions of kappa light chains. The IgK family is a crucial component of the adaptive immune response, participating in the production of antibodies and the activation of immune cells. IGKV2-29 is characterized by its specific expression in hematopoietic cells, including granulocyte-monocyte progenitor cells, early T lineage precursors, and neutrophil progenitors. This expression pattern suggests that IGKV2-29 plays a role in the development and maturation of these cells, potentially influencing their ability to recognize and respond to pathogens. **Pathways and Functions:** IGKV2-29 is involved in several key pathways, including the adaptive immune response, extracellular region, extracellular space, immune response, immunoglobulin complex, immunoglobulin production, and plasma membrane. The adaptive immune response is a critical process by which the immune system recognizes and responds to specific pathogens. IGKV2-29 is likely to participate in this process by contributing to the production of antibodies and the activation of immune cells. The expression of IGKV2-29 in hematopoietic cells also suggests that it may play a role in the development and maturation of immune cells, potentially influencing their ability to recognize and respond to pathogens. **Functions:** IGKV2-29 is likely to function as a component of the immunoglobulin complex, which is essential for the recognition and binding of pathogens. The expression of IGKV2-29 in hematopoietic cells also suggests that it may participate in the production of antibodies, which are critical for the clearance of pathogens from the body. Furthermore, IGKV2-29 may play a role in the activation of immune cells, such as T cells and natural killer cells, which are essential for the elimination of pathogens. **Clinical Significance:** The clinical significance of IGKV2-29 is an area of active research. Dysregulation of IGKV2-29 expression has been linked to various immunological disorders, including autoimmune diseases and cancer. For example, alterations in IGKV2-29 expression have been observed in patients with multiple sclerosis, a disease characterized by inflammation and demyelination in the central nervous system. Additionally, IGKV2-29 may play a role in the development of cancer, as altered expression of this gene has been observed in certain types of leukemia and lymphoma. Further research is needed to fully elucidate the clinical significance of IGKV2-29 and its potential as a therapeutic target for immunological disorders. In conclusion, IGKV2-29 is a critical component of the adaptive immune response, playing a role in the production of antibodies and the activation of immune cells. The expression of IGKV2-29 in hematopoietic cells highlights its involvement in the development and maturation of immune cells. Further research is needed to fully elucidate the clinical significance of IGKV2-29 and its potential as a therapeutic target for immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.