IGKV2 28 | ENSG00000244116 | NCBI 28921

Details for: IGKV2 28

Gene ID: 28921

Symbol: IGKV2 28

Ensembl ID: ENSG00000244116

Description: immunoglobulin kappa variable 2-28

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: leukocyte (CL0000738)
Fold Change: 0.0716
Cell Significance Index: 1.2200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.0168
Cell Significance Index: 0.2300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0076
Cell Significance Index: -0.1100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0184
Cell Significance Index: -0.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0360
Cell Significance Index: -1.6800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0400
Cell Significance Index: -1.0700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0716
Cell Significance Index: -0.8000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0721
Cell Significance Index: -0.4800
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0736
Cell Significance Index: -0.8700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0781
Cell Significance Index: -1.2700
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0784
Cell Significance Index: -0.9700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0797
Cell Significance Index: -2.0300
Cell Name: neutrophil (CL0000775)
Fold Change: -0.0833
Cell Significance Index: -1.0400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0865
Cell Significance Index: -2.1000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0921
Cell Significance Index: -1.8000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0943
Cell Significance Index: -1.1100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.0959
Cell Significance Index: -1.0200
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0963
Cell Significance Index: -1.2800
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0967
Cell Significance Index: -1.1800
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.0993
Cell Significance Index: -0.8800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1018
Cell Significance Index: -1.0400
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1027
Cell Significance Index: -1.4600
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.1032
Cell Significance Index: -1.6600
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.1118
Cell Significance Index: -1.4400
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.1120
Cell Significance Index: -1.5700
Cell Name: B cell (CL0000236)
Fold Change: -0.1134
Cell Significance Index: -1.3400
Cell Name: mast cell (CL0000097)
Fold Change: -0.1136
Cell Significance Index: -1.5000
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.1139
Cell Significance Index: -1.0300
Cell Name: B-1b B cell (CL0000821)
Fold Change: -0.1156
Cell Significance Index: -0.5800
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1182
Cell Significance Index: -1.5300
Cell Name: naive B cell (CL0000788)
Fold Change: -0.1206
Cell Significance Index: -1.2700
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1230
Cell Significance Index: -1.5800
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1245
Cell Significance Index: -1.7100
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1261
Cell Significance Index: -1.5500
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.1262
Cell Significance Index: -1.5000
Cell Name: pericyte (CL0000669)
Fold Change: -0.1268
Cell Significance Index: -1.5200
Cell Name: monocyte (CL0000576)
Fold Change: -0.1278
Cell Significance Index: -1.4700
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1310
Cell Significance Index: -1.7100
Cell Name: basal cell (CL0000646)
Fold Change: -0.1311
Cell Significance Index: -1.5600
Cell Name: macrophage (CL0000235)
Fold Change: -0.1322
Cell Significance Index: -1.3500
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1348
Cell Significance Index: -1.2200
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.1361
Cell Significance Index: -1.2300
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.1362
Cell Significance Index: -1.5700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1362
Cell Significance Index: -0.8900
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.1372
Cell Significance Index: -1.5200
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1390
Cell Significance Index: -1.6200
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.1391
Cell Significance Index: -1.4100
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1395
Cell Significance Index: -1.8300
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1406
Cell Significance Index: -1.4200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1409
Cell Significance Index: -1.6700
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1437
Cell Significance Index: -1.5500
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1437
Cell Significance Index: -1.4900
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.1442
Cell Significance Index: -1.5900
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.1452
Cell Significance Index: -1.3100
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.1459
Cell Significance Index: -1.5800
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.1464
Cell Significance Index: -1.4900
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.1467
Cell Significance Index: -1.6100
Cell Name: B-1a B cell (CL0000820)
Fold Change: -0.1468
Cell Significance Index: -0.7800
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1476
Cell Significance Index: -1.3500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1485
Cell Significance Index: -1.6600
Cell Name: stem cell (CL0000034)
Fold Change: -0.1510
Cell Significance Index: -1.1000
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1517
Cell Significance Index: -1.7600
Cell Name: T cell (CL0000084)
Fold Change: -0.1533
Cell Significance Index: -1.8100
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.1533
Cell Significance Index: -1.6700
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.1549
Cell Significance Index: -1.3500
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.1559
Cell Significance Index: -0.8700
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.1568
Cell Significance Index: -1.2600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.1573
Cell Significance Index: -1.4600
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.1574
Cell Significance Index: -1.3300
Cell Name: goblet cell (CL0000160)
Fold Change: -0.1581
Cell Significance Index: -1.4300
Cell Name: fibroblast (CL0000057)
Fold Change: -0.1598
Cell Significance Index: -1.5000
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1640
Cell Significance Index: -1.7300
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.1688
Cell Significance Index: -1.6000
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.1700
Cell Significance Index: -1.5900
Cell Name: immature B cell (CL0000816)
Fold Change: -0.1702
Cell Significance Index: -1.6100
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1707
Cell Significance Index: -1.8100
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.1723
Cell Significance Index: -1.6800
Cell Name: enterocyte (CL0000584)
Fold Change: -0.1725
Cell Significance Index: -1.0700
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1729
Cell Significance Index: -1.6100
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.1742
Cell Significance Index: -1.6000
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: -0.1752
Cell Significance Index: -1.5200
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.1757
Cell Significance Index: -1.9500
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.1766
Cell Significance Index: -1.8300
Cell Name: platelet (CL0000233)
Fold Change: -0.1779
Cell Significance Index: -1.8300
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.1781
Cell Significance Index: -1.4700
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1782
Cell Significance Index: -1.5700
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.1785
Cell Significance Index: -1.5400
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.1794
Cell Significance Index: -1.6000
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.1813
Cell Significance Index: -1.7400
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.1814
Cell Significance Index: -1.5000
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.1816
Cell Significance Index: -1.9300
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.1835
Cell Significance Index: -1.7100
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.1842
Cell Significance Index: -2.1200
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1846
Cell Significance Index: -2.0800
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1855
Cell Significance Index: -1.5800
Cell Name: mature B cell (CL0000785)
Fold Change: -0.1859
Cell Significance Index: -1.2100
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.1881
Cell Significance Index: -1.7400
Cell Name: mucous neck cell (CL0000651)
Fold Change: -0.1885
Cell Significance Index: -0.9000
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1893
Cell Significance Index: -2.1500
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.1907
Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV2-28 is a member of the immunoglobulin superfamily, which includes genes that encode proteins involved in the recognition and binding of antigens. The gene is specifically associated with the kappa light chain of the BCR complex, which is composed of a heavy chain, a light chain, and a signaling complex. The kappa light chain is responsible for recognizing and binding to specific antigens, triggering a cascade of signaling events that ultimately lead to the activation of B cells and the production of antibodies. IGKV2-28 is expressed in various cell types, including T cells, monocytes, lymphocytes, and granulocytes, and is involved in various immune responses, including anti-inflammatory responses to Leishmania parasite infections, antigen presentation, and phagocytosis. **Pathways and Functions** IGKV2-28 is involved in several key immune pathways, including: 1. **Adaptive Immune Response**: IGKV2-28 is essential for the recognition and binding of antigens, triggering a cascade of signaling events that ultimately lead to the activation of B cells and the production of antibodies. 2. **Anti-inflammatory Response**: IGKV2-28 is involved in the anti-inflammatory response to Leishmania parasite infections, where it helps to regulate the production of inflammatory cytokines and promote the resolution of inflammation. 3. **Antigen Presentation**: IGKV2-28 is involved in the presentation of antigens to T cells, which is essential for the activation of T cells and the initiation of an immune response. 4. **Phagocytosis**: IGKV2-28 is involved in the regulation of phagocytosis, where it helps to regulate the production of signaling molecules that promote the uptake of pathogens by phagocytic cells. 5. **Complement Activation**: IGKV2-28 is involved in the activation of the complement cascade, where it helps to regulate the production of complement proteins that promote the clearance of pathogens. **Clinical Significance** IGKV2-28 has significant clinical implications for various diseases, including: 1. **Leishmania Infections**: IGKV2-28 is involved in the anti-inflammatory response to Leishmania parasite infections, where it helps to regulate the production of inflammatory cytokines and promote the resolution of inflammation. 2. **Autoimmune Diseases**: IGKV2-28 is involved in the regulation of autoimmune responses, where it helps to regulate the production of antibodies and promote the resolution of inflammation. 3. **Cancer**: IGKV2-28 is involved in the regulation of immune responses to cancer, where it helps to regulate the production of antibodies and promote the clearance of tumor cells. 4. **Viral Infections**: IGKV2-28 is involved in the regulation of immune responses to viral infections, where it helps to regulate the production of antibodies and promote the clearance of viral particles. In conclusion, IGKV2-28 is a critical component of the BCR complex, which plays a central role in the adaptive immune response. The gene is involved in various immune pathways, including anti-inflammatory responses, antigen presentation, phagocytosis, and complement activation. Its dysregulation has significant clinical implications for various diseases, including Leishmania infections, autoimmune diseases, cancer, and viral infections.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.