IGKV2 28 | ENSG00000244116 | NCBI 28921

Details for: IGKV2 28

Gene ID: 28921

Symbol: IGKV2 28

Ensembl ID: ENSG00000244116

Description: immunoglobulin kappa variable 2-28

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T cell (CL0000084)
Fold Change: 2.48
Marker Score: 4,272
Cell Name: monocyte (CL0000576)
Fold Change: 1.67
Marker Score: 2,165
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.38
Marker Score: 699
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 875
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,691
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 801
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,321
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 495
Cell Name: Unknown (CL0000003)
Fold Change: 0.79
Marker Score: 2,457
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,273
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: naive B cell (CL0000788)
Fold Change: 0.76
Marker Score: 681
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1,196
Cell Name: B cell (CL0000236)
Fold Change: 0.74
Marker Score: 708
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.74
Marker Score: 490
Cell Name: fibroblast (CL0000057)
Fold Change: 0.72
Marker Score: 700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.72
Marker Score: 184
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.65
Marker Score: 519
Cell Name: neutrophil (CL0000775)
Fold Change: 0.63
Marker Score: 382
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.58
Marker Score: 154
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 239
Cell Name: macrophage (CL0000235)
Fold Change: 0.5
Marker Score: 551
Cell Name: plasma cell (CL0000786)
Fold Change: 0.49
Marker Score: 552
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 469
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 252
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 385
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.43
Marker Score: 295
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.38
Marker Score: 378
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.29
Marker Score: 125
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.26
Marker Score: 318
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.26
Marker Score: 66
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.25
Marker Score: 61
Cell Name: memory B cell (CL0000787)
Fold Change: 0.23
Marker Score: 174
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.23
Marker Score: 122
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.22
Marker Score: 362
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.22
Marker Score: 50
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.21
Marker Score: 59
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.21
Marker Score: 470
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.2
Marker Score: 264
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.2
Marker Score: 53
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.19
Marker Score: 67
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.15
Marker Score: 53
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.15
Marker Score: 112
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.14
Marker Score: 123
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.14
Marker Score: 130
Cell Name: immature B cell (CL0000816)
Fold Change: 0.14
Marker Score: 91
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.14
Marker Score: 105
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.13
Marker Score: 74
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.12
Marker Score: 68
Cell Name: plasmablast (CL0000980)
Fold Change: 0.12
Marker Score: 158
Cell Name: pericyte (CL0000669)
Fold Change: 0.12
Marker Score: 68
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.11
Marker Score: 52
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.11
Marker Score: 68
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.11
Marker Score: 65
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.1
Marker Score: 60
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1
Marker Score: 68
Cell Name: Unknown (CL0000548)
Fold Change: 0.09
Marker Score: 67
Cell Name: stromal cell (CL0000499)
Fold Change: 0.09
Marker Score: 107
Cell Name: platelet (CL0000233)
Fold Change: 0.09
Marker Score: 41
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.09
Marker Score: 65
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.09
Marker Score: 59
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.09
Marker Score: 67
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.08
Marker Score: 102
Cell Name: mature B cell (CL0000785)
Fold Change: 0.08
Marker Score: 59
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.08
Marker Score: 68
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.08
Marker Score: 64
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.08
Marker Score: 65
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.08
Marker Score: 83
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.07
Marker Score: 59
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.07
Marker Score: 59
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 140
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.07
Marker Score: 67
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.06
Marker Score: 68
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.06
Marker Score: 107
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.06
Marker Score: 151
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.06
Marker Score: 250
Cell Name: glial cell (CL0000125)
Fold Change: 0.05
Marker Score: 51
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.04
Marker Score: 52
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.04
Marker Score: 67
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.04
Marker Score: 40
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.03
Marker Score: 51
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.03
Marker Score: 67
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.02
Marker Score: 58
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.02
Marker Score: 63
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.02
Marker Score: 53
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.02
Marker Score: 67
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.01
Marker Score: 75
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.01
Marker Score: 68
Cell Name: enterocyte (CL0000584)
Fold Change: 0.01
Marker Score: 43
Cell Name: blood cell (CL0000081)
Fold Change: 0.01
Marker Score: 67
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0
Marker Score: 67

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGKV2-28 is a member of the immunoglobulin superfamily, which includes genes that encode proteins involved in the recognition and binding of antigens. The gene is specifically associated with the kappa light chain of the BCR complex, which is composed of a heavy chain, a light chain, and a signaling complex. The kappa light chain is responsible for recognizing and binding to specific antigens, triggering a cascade of signaling events that ultimately lead to the activation of B cells and the production of antibodies. IGKV2-28 is expressed in various cell types, including T cells, monocytes, lymphocytes, and granulocytes, and is involved in various immune responses, including anti-inflammatory responses to Leishmania parasite infections, antigen presentation, and phagocytosis. **Pathways and Functions** IGKV2-28 is involved in several key immune pathways, including: 1. **Adaptive Immune Response**: IGKV2-28 is essential for the recognition and binding of antigens, triggering a cascade of signaling events that ultimately lead to the activation of B cells and the production of antibodies. 2. **Anti-inflammatory Response**: IGKV2-28 is involved in the anti-inflammatory response to Leishmania parasite infections, where it helps to regulate the production of inflammatory cytokines and promote the resolution of inflammation. 3. **Antigen Presentation**: IGKV2-28 is involved in the presentation of antigens to T cells, which is essential for the activation of T cells and the initiation of an immune response. 4. **Phagocytosis**: IGKV2-28 is involved in the regulation of phagocytosis, where it helps to regulate the production of signaling molecules that promote the uptake of pathogens by phagocytic cells. 5. **Complement Activation**: IGKV2-28 is involved in the activation of the complement cascade, where it helps to regulate the production of complement proteins that promote the clearance of pathogens. **Clinical Significance** IGKV2-28 has significant clinical implications for various diseases, including: 1. **Leishmania Infections**: IGKV2-28 is involved in the anti-inflammatory response to Leishmania parasite infections, where it helps to regulate the production of inflammatory cytokines and promote the resolution of inflammation. 2. **Autoimmune Diseases**: IGKV2-28 is involved in the regulation of autoimmune responses, where it helps to regulate the production of antibodies and promote the resolution of inflammation. 3. **Cancer**: IGKV2-28 is involved in the regulation of immune responses to cancer, where it helps to regulate the production of antibodies and promote the clearance of tumor cells. 4. **Viral Infections**: IGKV2-28 is involved in the regulation of immune responses to viral infections, where it helps to regulate the production of antibodies and promote the clearance of viral particles. In conclusion, IGKV2-28 is a critical component of the BCR complex, which plays a central role in the adaptive immune response. The gene is involved in various immune pathways, including anti-inflammatory responses, antigen presentation, phagocytosis, and complement activation. Its dysregulation has significant clinical implications for various diseases, including Leishmania infections, autoimmune diseases, cancer, and viral infections.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.