Details for: GSTM4

Gene ID: 2948

Symbol: GSTM4

Ensembl ID: ENSG00000168765

Description: glutathione S-transferase mu 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.85
    Marker Score: 2857
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.64
    Marker Score: 7855
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.32
    Marker Score: 3137
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.28
    Marker Score: 370
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.17
    Marker Score: 439
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.15
    Marker Score: 1026
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.13
    Marker Score: 3555
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.11
    Marker Score: 6575
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.08
    Marker Score: 2952
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1082
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.03
    Marker Score: 249
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 237
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47965
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.97
    Marker Score: 2457
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.97
    Marker Score: 1220
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14555
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5266
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.91
    Marker Score: 970
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.91
    Marker Score: 1291
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.9
    Marker Score: 296
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5245
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.86
    Marker Score: 859
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.84
    Marker Score: 2261
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.82
    Marker Score: 8256
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 868
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1163
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.79
    Marker Score: 1435
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.78
    Marker Score: 1277
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.75
    Marker Score: 792
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1749
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.73
    Marker Score: 4776
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.73
    Marker Score: 3163
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.72
    Marker Score: 1192
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.71
    Marker Score: 291
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7
    Marker Score: 849
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.69
    Marker Score: 346
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.69
    Marker Score: 496
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.69
    Marker Score: 652
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.69
    Marker Score: 1394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.67
    Marker Score: 2368
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.66
    Marker Score: 4945
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1246.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.66
    Marker Score: 696
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.65
    Marker Score: 417
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2678.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.64
    Marker Score: 786
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.63
    Marker Score: 1644
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.62
    Marker Score: 176
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.62
    Marker Score: 1710
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.62
    Marker Score: 5301
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.61
    Marker Score: 321
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.61
    Marker Score: 210
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.61
    Marker Score: 253
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6
    Marker Score: 2372
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.59
    Marker Score: 1392
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.59
    Marker Score: 115
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.58
    Marker Score: 587
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.57
    Marker Score: 306
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1157
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.57
    Marker Score: 163
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.56
    Marker Score: 560
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.56
    Marker Score: 256
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.56
    Marker Score: 1266
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 402
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.53
    Marker Score: 151
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.53
    Marker Score: 361
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.53
    Marker Score: 509
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.53
    Marker Score: 349
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.53
    Marker Score: 331.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 703
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.53
    Marker Score: 131
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 485
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 241
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.52
    Marker Score: 287
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.52
    Marker Score: 1085.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.51
    Marker Score: 2091
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 341
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.51
    Marker Score: 350
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.51
    Marker Score: 6686
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.5
    Marker Score: 161
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5
    Marker Score: 115

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Other Information

**Key characteristics**: * GSTM4 is a large protein (350 kDa) that is expressed in a variety of cell types. * It is a member of the glutathione S-transferase family of enzymes that are involved in the metabolism of glutathione, a molecule that is important for a variety of cellular processes. * GSTM4 is a key enzyme in the biosynthesis of specialized proresolving mediators (spms), which are a family of cytokines that are involved in the regulation of inflammation. * It is also involved in the biosynthesis of other molecules, such as the pro-resolving lipid DHA and the maresin conjugates. **Pathways and functions:** * GSTM4 is involved in a variety of cellular processes, including the metabolism of glutathione, the biosynthesis of spms, and the regulation of inflammation. * It is involved in the maintenance of intestinal homeostasis by regulating the production of spms, which are short-lived cytokines that are involved in the regulation of inflammation and tissue repair. * It is also involved in the regulation of tissue regeneration by promoting the migration and proliferation of stem cells. **Clinical significance:** GSTM4 is a potential therapeutic target for a variety of diseases, including inflammatory bowel disease (IBD), colon cancer, and liver disease. Inhibitors of GSTM4 have been shown to be effective in promoting the production of spms, which can lead to the inhibition of inflammation and tissue damage.

Genular Protein ID: 1678748881

Symbol: GSTM4_HUMAN

Name: Glutathione S-transferase Mu 4

UniProtKB Accession Codes:

Q03013 A8K765 Q05465 Q32NC1 Q4JNT8 Q6FH87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 3 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8349586

Title: Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4.

PubMed ID: 8349586

DOI: 10.1016/s0021-9258(19)85287-0

PubMed ID: 8471052

Title: Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.

PubMed ID: 8471052

DOI: 10.1042/bj2910041

PubMed ID: 8373352

Title: Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.

PubMed ID: 8373352

DOI: 10.1042/bj2940373

PubMed ID: 16854533

Title: Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons.

PubMed ID: 16854533

DOI: 10.1016/j.gene.2006.05.012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2006920

Title: Structure of human glutathione S-transferase class Mu genes.

PubMed ID: 2006920

DOI: 10.1042/bj2740587

PubMed ID: 8203914

Title: A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.

PubMed ID: 8203914

DOI: 10.1006/abbi.1994.1266

PubMed ID: 10587441

Title: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.

PubMed ID: 10587441

DOI: 10.1021/bi991714t

PubMed ID: 27791009

Title: Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

PubMed ID: 27791009

DOI: 10.1073/pnas.1607003113

Sequence Information:

  • Length: 218
  • Mass: 25561
  • Checksum: 35E96FA54D566B1E
  • Sequence:
    • MSMTLGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQAMDVSNQ LARVCYSPDF 
EKLKPEYLEE LPTMMQHFSQ FLGKRPWFVG DKITFVDFLA YDVLDLHRIF EPNCLDAFPN 
LKDFISRFEG LEKISAYMKS SRFLPKPLYT RVAVWGNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.