Details for: HLA K

Gene ID: 3138

Symbol: HLA K

Ensembl ID: ENSG00000230795

Description: major histocompatibility complex, class I, K (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.9116
    Cell Significance Index: 11.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.5452
    Cell Significance Index: 7.1300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.3076
    Cell Significance Index: 3.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2777
    Cell Significance Index: 8.0000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.2449
    Cell Significance Index: 1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1596
    Cell Significance Index: 4.7000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.1590
    Cell Significance Index: 1.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0972
    Cell Significance Index: 5.0500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0882
    Cell Significance Index: 1.1400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.0838
    Cell Significance Index: 0.8900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0701
    Cell Significance Index: 0.5800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0415
    Cell Significance Index: 0.3500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0223
    Cell Significance Index: 0.3100
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0165
    Cell Significance Index: 0.1200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0133
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0032
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0044
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0050
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0068
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0164
    Cell Significance Index: -2.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0165
    Cell Significance Index: -0.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0290
    Cell Significance Index: -3.0200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0311
    Cell Significance Index: -0.2900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0331
    Cell Significance Index: -0.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0349
    Cell Significance Index: -2.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0364
    Cell Significance Index: -1.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0485
    Cell Significance Index: -0.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0550
    Cell Significance Index: -0.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0614
    Cell Significance Index: -0.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0659
    Cell Significance Index: -2.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0663
    Cell Significance Index: -0.9200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0761
    Cell Significance Index: -0.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0795
    Cell Significance Index: -2.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0816
    Cell Significance Index: -2.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0823
    Cell Significance Index: -1.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0863
    Cell Significance Index: -2.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1006
    Cell Significance Index: -1.7200
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.1017
    Cell Significance Index: -1.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1107
    Cell Significance Index: -1.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1127
    Cell Significance Index: -2.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1215
    Cell Significance Index: -2.5200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1224
    Cell Significance Index: -1.1400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1247
    Cell Significance Index: -1.2500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1283
    Cell Significance Index: -1.9200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1284
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1284
    Cell Significance Index: -1.0400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1289
    Cell Significance Index: -2.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1370
    Cell Significance Index: -1.3900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1374
    Cell Significance Index: -2.0600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1477
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1480
    Cell Significance Index: -1.5600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1504
    Cell Significance Index: -1.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1509
    Cell Significance Index: -1.6400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1510
    Cell Significance Index: -1.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1533
    Cell Significance Index: -1.9700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1560
    Cell Significance Index: -1.9000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1613
    Cell Significance Index: -1.7100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1626
    Cell Significance Index: -1.7600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1641
    Cell Significance Index: -1.5700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1647
    Cell Significance Index: -1.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1658
    Cell Significance Index: -2.3600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1686
    Cell Significance Index: -1.5600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1689
    Cell Significance Index: -2.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1704
    Cell Significance Index: -2.1500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1728
    Cell Significance Index: -1.8900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1761
    Cell Significance Index: -2.0700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1782
    Cell Significance Index: -1.8000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1788
    Cell Significance Index: -1.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1824
    Cell Significance Index: -2.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1828
    Cell Significance Index: -1.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1831
    Cell Significance Index: -1.7600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1836
    Cell Significance Index: -2.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1900
    Cell Significance Index: -2.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1938
    Cell Significance Index: -2.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1963
    Cell Significance Index: -2.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1979
    Cell Significance Index: -2.2300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1984
    Cell Significance Index: -2.0800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1995
    Cell Significance Index: -2.7400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2005
    Cell Significance Index: -3.0500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2042
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2047
    Cell Significance Index: -2.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2051
    Cell Significance Index: -2.9500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2054
    Cell Significance Index: -2.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2066
    Cell Significance Index: -2.5400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2071
    Cell Significance Index: -2.3400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2092
    Cell Significance Index: -2.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2109
    Cell Significance Index: -2.4900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2165
    Cell Significance Index: -2.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2191
    Cell Significance Index: -2.9800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2195
    Cell Significance Index: -2.3400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2196
    Cell Significance Index: -2.7500
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2217
    Cell Significance Index: -1.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** The HLA K gene has undergone mutations and deletions, leading to its loss of functional ability to present antigens to the immune system. 2. **Widespread expression:** The HLA K gene is expressed in a variety of cell types, including CD4-positive and CD8-positive T cells, B cells, macrophages, and smooth muscle cells. 3. **Cell type specificity:** The expression of HLA K is cell-type specific, suggesting that it may play a role in regulating immune responses in specific cell types. 4. **Evolutionary conservation:** The HLA K gene has been conserved across species, indicating its importance in maintaining immune homeostasis. **Pathways and Functions:** 1. **Antigen presentation:** Although the HLA K gene is pseudogenic, it may still play a role in regulating antigen presentation to the immune system, potentially through indirect mechanisms such as influencing the expression of other HLA genes. 2. **Immune regulation:** The expression of HLA K in immune cells suggests that it may be involved in regulating immune responses, such as modulating T cell activation and proliferation. 3. **Cell-cell interactions:** The presence of HLA K in non-immune cells, such as smooth muscle cells and macrophages, may facilitate cell-cell interactions and regulate tissue homeostasis. 4. **Hematopoiesis:** The expression of HLA K in hematopoietic stem cells suggests that it may play a role in regulating hematopoiesis and maintaining immune homeostasis. **Clinical Significance:** 1. **Cancer immunotherapy:** The expression of HLA K in cancer cells may have implications for cancer immunotherapy, as it may influence the ability of the immune system to recognize and target cancer cells. 2. **Autoimmune diseases:** The expression of HLA K in immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, by regulating immune responses and promoting inflammation. 3. **Infectious diseases:** The presence of HLA K in macrophages and other immune cells may facilitate the recognition and elimination of pathogens, highlighting its potential role in protecting against infectious diseases. 4. **Regenerative medicine:** The expression of HLA K in smooth muscle cells and other non-immune cells may have implications for regenerative medicine, as it may influence tissue repair and regeneration. In conclusion, the HLA K gene is a fascinating and enigmatic member of the HLA family, with implications for immune regulation, cell-cell interactions, and disease. Further research is needed to fully understand the functions and clinical significance of this pseudogenic gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.