Details for: HTN3

Gene ID: 3347

Symbol: HTN3

Ensembl ID: ENSG00000205649

Description: histatin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 99.0592
    Cell Significance Index: 551.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 73.5114
    Cell Significance Index: 1533.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 6.2283
    Cell Significance Index: 62.9200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.6023
    Cell Significance Index: 48.2400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.9396
    Cell Significance Index: 18.0000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.9749
    Cell Significance Index: 10.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6506
    Cell Significance Index: 15.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1235
    Cell Significance Index: 1.8000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1116
    Cell Significance Index: 1.5300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.0430
    Cell Significance Index: 0.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0335
    Cell Significance Index: 0.4200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0182
    Cell Significance Index: 0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0161
    Cell Significance Index: 0.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0079
    Cell Significance Index: 0.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0014
    Cell Significance Index: 0.0700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0014
    Cell Significance Index: -0.3000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0033
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0039
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0061
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0113
    Cell Significance Index: -2.2700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0133
    Cell Significance Index: -0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0165
    Cell Significance Index: -3.2700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0201
    Cell Significance Index: -0.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0205
    Cell Significance Index: -0.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0274
    Cell Significance Index: -0.3900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0288
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0307
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0330
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0352
    Cell Significance Index: -0.3600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0396
    Cell Significance Index: -0.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0409
    Cell Significance Index: -0.8000
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0460
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0485
    Cell Significance Index: -0.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0487
    Cell Significance Index: -2.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0514
    Cell Significance Index: -0.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0537
    Cell Significance Index: -1.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0573
    Cell Significance Index: -0.7800
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0577
    Cell Significance Index: -0.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0583
    Cell Significance Index: -3.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0598
    Cell Significance Index: -0.6300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0609
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0613
    Cell Significance Index: -0.7400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0616
    Cell Significance Index: -0.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0617
    Cell Significance Index: -2.1600
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0625
    Cell Significance Index: -0.5500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0651
    Cell Significance Index: -0.6300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0655
    Cell Significance Index: -0.7900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0660
    Cell Significance Index: -0.6000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0669
    Cell Significance Index: -0.4200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0681
    Cell Significance Index: -0.8100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0692
    Cell Significance Index: -0.7800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0704
    Cell Significance Index: -0.7700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0707
    Cell Significance Index: -0.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0709
    Cell Significance Index: -0.9300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0718
    Cell Significance Index: -0.7500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0720
    Cell Significance Index: -0.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0723
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0733
    Cell Significance Index: -0.9300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0733
    Cell Significance Index: -0.7600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0734
    Cell Significance Index: -0.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0741
    Cell Significance Index: -0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0744
    Cell Significance Index: -1.6300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0750
    Cell Significance Index: -1.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0766
    Cell Significance Index: -2.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0801
    Cell Significance Index: -2.1800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0809
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0833
    Cell Significance Index: -1.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0850
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0851
    Cell Significance Index: -2.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0855
    Cell Significance Index: -1.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0880
    Cell Significance Index: -1.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0922
    Cell Significance Index: -0.6000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0930
    Cell Significance Index: -1.0800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0933
    Cell Significance Index: -1.2400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0945
    Cell Significance Index: -1.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0949
    Cell Significance Index: -1.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0958
    Cell Significance Index: -1.8700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0960
    Cell Significance Index: -1.1200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0969
    Cell Significance Index: -0.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0982
    Cell Significance Index: -1.5900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0994
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antimicrobial peptides:** HTN3 is a member of the antimicrobial peptide family, which plays a crucial role in the innate immune response against pathogens. 2. **Metal ion binding:** The protein has metal ion-binding capabilities, which may contribute to its antimicrobial and regulatory functions. 3. **Molecular adaptor activity:** Histatin 3 acts as a molecular adaptor, facilitating interactions between proteins and other molecules to regulate various cellular processes. 4. **Expression in multiple cell types:** HTN3 is expressed in a wide range of cell types, including progenitor cells, immune cells, and epithelial cells, suggesting its broad functional significance. **Pathways and Functions:** 1. **Innate immune response:** Histatin 3 is involved in the defense response against bacteria and fungi, highlighting its role in the innate immune system. 2. **Biomineral tissue development:** The protein may contribute to the regulation of biomineralization processes, such as bone and teeth development. 3. **Wound healing:** Histatin 3 is upregulated in response to wound injury, suggesting its involvement in the regulation of wound healing processes. 4. **Fibroblast proliferation and wound healing:** The protein positively regulates fibroblast proliferation, a key step in wound healing. **Clinical Significance:** 1. **Dental and oral health:** Histatin 3 is expressed in salivary gland acinar cells and plays a role in antimicrobial defense against oral pathogens, highlighting its importance in dental health. 2. **Infectious diseases:** The protein's antimicrobial properties may contribute to the defense against bacterial and fungal infections, making it a potential target for therapeutic interventions. 3. **Wound healing and tissue repair:** Histatin 3's role in wound healing and tissue repair highlights its potential as a therapeutic target for the treatment of wounds and tissue injuries. 4. **Cancer and inflammation:** Further research is needed to determine the role of histatin 3 in cancer and inflammation, as its expression and function in these contexts may provide valuable insights into its clinical significance. In conclusion, histatin 3 is a multifaceted gene involved in various cellular processes, including innate immunity, tissue development, and wound healing. Its clinical significance is underscored by its expression in multiple cell types and its potential roles in dental and oral health, infectious diseases, wound healing, and cancer. Further research is needed to fully elucidate the functions and clinical significance of histatin 3, but its current understanding highlights its importance as a potential therapeutic target and biomarker.

Genular Protein ID: 574445270

Symbol: HIS3_HUMAN

Name: Histatin-3

UniProtKB Accession Codes:

P15516 Q16243 Q502Z1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2719677

Title: Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).

PubMed ID: 2719677

DOI: 10.1016/0006-291x(89)92460-1

PubMed ID: 3426601

Title: Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.

PubMed ID: 3426601

DOI: 10.1016/0006-291x(87)90436-0

PubMed ID: 2344289

Title: Molecular cloning of human submandibular histatins.

PubMed ID: 2344289

DOI: 10.1016/0003-9969(90)90175-a

PubMed ID: 8336540

Title: Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.

PubMed ID: 8336540

DOI: 10.1093/oxfordjournals.molbev.a040022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7951254

Title: Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant.

PubMed ID: 7951254

DOI: 10.1002/humu.1380040103

PubMed ID: 3286634

Title: Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.

PubMed ID: 3286634

DOI: 10.1016/s0021-9258(18)68522-9

PubMed ID: 2372245

Title: Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.

PubMed ID: 2372245

DOI: 10.1016/0003-9969(90)90202-l

PubMed ID: 15272024

Title: A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway.

PubMed ID: 15272024

DOI: 10.1074/jbc.m404322200

PubMed ID: 8945538

Title: Candidacidal activity of recombinant human salivary histatin-5 and variants.

PubMed ID: 8945538

DOI: 10.1128/iai.64.12.5000-5007.1996

PubMed ID: 10423240

Title: Zn(2+) ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles. Identification and characterization of a zinc-binding motif present in the functional domain.

PubMed ID: 10423240

DOI: 10.1021/bi990212c

PubMed ID: 10066791

Title: The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.

PubMed ID: 10066791

DOI: 10.1074/jbc.274.11.7286

PubMed ID: 11083804

Title: Released ATP is an extracellular cytotoxic mediator in salivary histatin 5-induced killing of Candida albicans.

PubMed ID: 11083804

DOI: 10.1128/iai.68.12.6848-6856.2000

PubMed ID: 11226423

Title: Zinc and copper bind to unique sites of histatin 5.

PubMed ID: 11226423

DOI: 10.1016/s0014-5793(01)02157-3

PubMed ID: 11179305

Title: Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.

PubMed ID: 11179305

DOI: 10.1128/iai.69.3.1402-1408.2001

PubMed ID: 11717389

Title: The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species.

PubMed ID: 11717389

DOI: 10.1073/pnas.141366998

PubMed ID: 12761219

Title: Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5.

PubMed ID: 12761219

DOI: 10.1074/jbc.m300680200

PubMed ID: 12939362

Title: Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans.

PubMed ID: 12939362

DOI: 10.1177/154405910308200917

PubMed ID: 15485849

Title: The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.

PubMed ID: 15485849

DOI: 10.1074/jbc.m411031200

PubMed ID: 14966203

Title: Immunocytochemical localization of histatins in human salivary glands.

PubMed ID: 14966203

DOI: 10.1177/002215540405200307

PubMed ID: 17503797

Title: Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.

PubMed ID: 17503797

DOI: 10.1021/pr0700706

PubMed ID: 18650243

Title: Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.

PubMed ID: 18650243

DOI: 10.1096/fj.08-112003

PubMed ID: 18974864

Title: The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm.

PubMed ID: 18974864

DOI: 10.1371/journal.ppat.1000190

PubMed ID: 19846304

Title: A plausible role of salivary copper in antimicrobial activity of histatin-5--metal binding and oxidative activity of its copper complex.

PubMed ID: 19846304

DOI: 10.1016/j.bmcl.2009.09.119

PubMed ID: 20973643

Title: Salivary peptidomics.

PubMed ID: 20973643

DOI: 10.1586/epr.10.48

PubMed ID: 20487276

Title: Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.

PubMed ID: 20487276

DOI: 10.1111/j.1365-2958.2010.07210.x

PubMed ID: 22033918

Title: Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.

PubMed ID: 22033918

DOI: 10.1074/jbc.m111.311175

PubMed ID: 23613860

Title: Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31.

PubMed ID: 23613860

DOI: 10.1371/journal.pone.0061480

PubMed ID: 26379655

Title: Histatin 5 inhibits adhesion of C. albicans to Reconstructed Human Oral Epithelium.

PubMed ID: 26379655

DOI: 10.3389/fmicb.2015.00885

PubMed ID: 27390786

Title: The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.

PubMed ID: 27390786

DOI: 10.18388/abp.2016_1318

PubMed ID: 26775844

Title: Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.

PubMed ID: 26775844

DOI: 10.1016/j.bbrc.2016.01.072

PubMed ID: 28261570

Title: Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens.

PubMed ID: 28261570

DOI: 10.3389/fcimb.2017.00041

PubMed ID: 28763199

Title: Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.

PubMed ID: 28763199

DOI: 10.1021/acs.biochem.7b00348

PubMed ID: 32225006

Title: Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.

PubMed ID: 32225006

DOI: 10.3390/cells9040795

PubMed ID: 32751915

Title: Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption in C. albicans and C. glabrata.

PubMed ID: 32751915

DOI: 10.3390/jof6030124

PubMed ID: 31675138

Title: Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.

PubMed ID: 31675138

DOI: 10.1002/pro.3767

Sequence Information:

  • Length: 51
  • Mass: 6149
  • Checksum: AFCCB4B32083FD65
  • Sequence:
    • MKFFVFALIL ALMLSMTGAD SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.